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International Journal of Hematology
Erschienen in:

02.05.2023 | Original Article

Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice

verfasst von: Satomi Sahashi, Kazuyuki Shimada, Yusuke Takagi, Tomohiro Aoki, Shunsuke Kunou, Akihiko Sakamoto, Atsushi Murase, Katsuya Furukawa, Yusuke Kagaya, Yusuke Yamaga, Mika Takai, Kiyonobu Tokuyama, Satoko Shimada, Shigeo Nakamura, Hitoshi Kiyoi

Erschienen in: International Journal of Hematology | Ausgabe 2/2023

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Abstract

Patient-derived xenograft (PDX) mouse models are useful for deepening our understanding of the biology of malignant lymphoma; however, factors associated with the success of the PDX lymphoma model are largely unknown. We retrospectively analyzed the characteristics of 66 xenotransplantations from 65 patients. In all, 43 (65%) specimens were obtained from patients aged > 60 years, and 42 (64%) specimens were obtained at diagnosis. Specimens were obtained from patients with the following diseases: diffuse large B-cell lymphoma (n = 30), intravascular large B-cell lymphoma (n = 12), follicular lymphoma (n = 8), peripheral T-cell lymphoma (n = 7), mantle cell lymphoma (n = 2), and other (n = 7). The specimens were sourced mainly from bone marrow (n = 31, 47%) and extranodal tumors (n = 13, 20%). Engraftment was successful in 33/66 (50%) xenotransplantations. The median age of patients who provided successful specimens was significantly higher than that for unsuccessful specimens (p = 0.013). Specimens with a high proportion of tumor cells in the graft and those obtained from patients with relapsed/refractory disease showed higher tendencies toward successful engraftment. Taken together, these data suggest that tumor cells with a highly malignant potential might have a high likelihood of engraftment.
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Metadaten
Titel
Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice
verfasst von
Satomi Sahashi
Kazuyuki Shimada
Yusuke Takagi
Tomohiro Aoki
Shunsuke Kunou
Akihiko Sakamoto
Atsushi Murase
Katsuya Furukawa
Yusuke Kagaya
Yusuke Yamaga
Mika Takai
Kiyonobu Tokuyama
Satoko Shimada
Shigeo Nakamura
Hitoshi Kiyoi
Publikationsdatum
02.05.2023
Verlag
Springer Nature Singapore
Erschienen in
International Journal of Hematology / Ausgabe 2/2023
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-023-03604-z

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