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Journal of Cancer Research and Clinical Oncology

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22.10.2016 | Original Article – Clinical Oncology

Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma

verfasst von: Kei Shimizu, Keisuke Kirita, Keiju Aokage, Motohiro Kojima, Tomoyuki Hishida, Takeshi Kuwata, Satoshi Fujii, Atsushi Ochiai, Kazuhito Funai, Junji Yoshida, Masahiro Tsuboi, Genichiro Ishii

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 2/2017

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Abstract

Purpose

Caveolin is an essential constituent of caveolae and has many biological functions. Expression of caveolin-1 in cancer cells was reported to be a prognostic marker in several types of cancers, the prognostic significance of its expression in cancer-associated fibroblasts (CAFs) has not been investigated. This study aimed to evaluate the clinicopathological significance of expression by CAFs in lung adenocarcinoma.

Methods

We examined caveolin-1 expression in both CAFs and cancer cells in stage I invasive lung adenocarcinoma (n = 412) and analyzed the relationship between the expression and clinicopathological factors.

Results

Caveolin-1 expression by CAFs and cancer cells was observed in 12.1% and 7.8% of adenocarcinomas, respectively. Tumors with caveolin-1-positive CAFs had vascular and pleural invasion significantly more frequently than those with caveolin-1-negative CAF (p < 0.05). This was also the cases with tumors with caveolin-1-positive cancer cells (p < 0.01). Caveolin-1 expression by CAFs and that by cancer cells were significant predictors of shorter recurrence-free survival (p < 0.001). Caveolin-1 expression by CAFs and cancer cells was found in 25% and 30% of solid predominant subtype, respectively, but only 9.2% and 2.7% of non-solid predominant subtype, respectively. The frequency of cases with caveolin-1-positive CAFs or cancer cells was significantly higher in the solid predominant subtype than in non-solid predominant subtype (p < 0.001).

Conclusions

Our current results highlight the prognostic importance of caveolin-1 expression by CAFs in stage I lung adenocarcinoma and provide new insights into the biological significance of caveolin-1 in the tumor microenvironment, especially in microenvironment of solid predominant adenocarcinoma.

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Titel: Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma
verfasst von: Kei Shimizu
Keisuke Kirita
Keiju Aokage
Motohiro Kojima
Tomoyuki Hishida
Takeshi Kuwata
Satoshi Fujii
Atsushi Ochiai
Kazuhito Funai
Junji Yoshida
Masahiro Tsuboi
Genichiro Ishii
Publikationsdatum: 22.10.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 2/2017
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2285-2

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Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma