Skip to main content
Erschienen in: Info Diabetologie 5/2022

24.10.2022 | Clostridien | Fortbildung

Effekte von Süßstoffverzehr bei Personen mit Diabetes mellitus

Süßstoffe - Modulatoren des Darmmikrobioms?

verfasst von: M. Sc. Linda Klümpen, Prof. Dr. med. Marie-Christine Simon

Erschienen in: Info Diabetologie | Ausgabe 5/2022

Einloggen, um Zugang zu erhalten

Auszug

Hohe Süßkraft und geringer Kaloriengehalt machen Süßstoffe scheinbar zu einer interessanten Alternative bei Diabetikern mit Übergewicht. Ob das eine gute Idee ist, wird aufgrund von negativen Assoziationen zwischen Süßstoff und humanen Stoffwechsel kontrovers diskutiert. Eine Schlüsselrolle könnte hier die Beeinflussung des Darmmikrobioms spielen.
Fußnoten
1
Der ADI-Wert gibt die Menge eines Zusatzstoffs an, die täglich während des gesamten Lebens pro Kilogramm Körpergewicht aufgenommen werden kann, ohne dass es zu gesundheitlichen Risiken kommt. (Bundesinstitut für Risikobewertung. Bewertung von Süßstoffen und Zuckeraustauschstoffen. Hintergrundinformation Nr. 025/2014 des BfR vom 1. Juli 2014. Im Internet (Stand: 11.5.2022): www.bfr.bund.de/cm/343/bewertung_von_suessstoffen.pdf)
 
Literatur
1.
Zurück zum Zitat Magnuson BA, Carakostas MC, Moore NH et al. Biological fate of low-calorie sweeteners. Nutr Rev. 2016;74(11):670-89 Magnuson BA, Carakostas MC, Moore NH et al. Biological fate of low-calorie sweeteners. Nutr Rev. 2016;74(11):670-89
2.
Zurück zum Zitat Sylvetsky AC, Rother KI. Trends in the Consumption of Low-Calorie Sweeteners. Physiol Behav. 2016;164:446-50 Sylvetsky AC, Rother KI. Trends in the Consumption of Low-Calorie Sweeteners. Physiol Behav. 2016;164:446-50
3.
Zurück zum Zitat Sylvetsky AC, Jin Y, Clark EJ et al. Consumption of Low-Calorie Sweeteners among Children and Adults in the United States. J Acad Nutr Diet. 2017;117(3):441-8.e2 Sylvetsky AC, Jin Y, Clark EJ et al. Consumption of Low-Calorie Sweeteners among Children and Adults in the United States. J Acad Nutr Diet. 2017;117(3):441-8.e2
4.
Zurück zum Zitat Turner A, Veysey M, Keely S et al. Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective. Int J Environ Res Public Health. 2020;17:4094 Turner A, Veysey M, Keely S et al. Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective. Int J Environ Res Public Health. 2020;17:4094
5.
Zurück zum Zitat Pepino MY. Metabolic Effects of Non-Nutritive Sweeteners. Physiol Behav. 2015;152(Pt B):450-5 Pepino MY. Metabolic Effects of Non-Nutritive Sweeteners. Physiol Behav. 2015;152(Pt B):450-5
6.
Zurück zum Zitat Swithers S. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab. 2013;24(9):431-41 Swithers S. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab. 2013;24(9):431-41
7.
Zurück zum Zitat Sylvetsky AC, Rother KI. Non-nutritive Sweeteners in Weight Management and Chronic Disease: a review. Obesity (Silver Spring). 2018;26(4): 635-40 Sylvetsky AC, Rother KI. Non-nutritive Sweeteners in Weight Management and Chronic Disease: a review. Obesity (Silver Spring). 2018;26(4): 635-40
8.
Zurück zum Zitat Miller PE, Perez V. Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies. Am J Clin Nutr. 2014;100(3):765-77 Miller PE, Perez V. Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies. Am J Clin Nutr. 2014;100(3):765-77
9.
Zurück zum Zitat Qin P, Li Q, Zhao Y et al. Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol. 2020;35(7):655-71 Qin P, Li Q, Zhao Y et al. Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol. 2020;35(7):655-71
10.
Zurück zum Zitat Greenwood D C, Threapleton DE, Evans CEL et al. Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and doseresponse meta-analysis of prospective studies. Br J Nutr. 2014;112(5):725-34 Greenwood D C, Threapleton DE, Evans CEL et al. Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and doseresponse meta-analysis of prospective studies. Br J Nutr. 2014;112(5):725-34
11.
Zurück zum Zitat Azad MB, Abou-Setta AM, Chauhan BF et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Can Med Assoc J. 2017;189(28):E929-39 Azad MB, Abou-Setta AM, Chauhan BF et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Can Med Assoc J. 2017;189(28):E929-39
12.
Zurück zum Zitat Suez J, Korem T, Zeevi D et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014; 514(7521):181-6 Suez J, Korem T, Zeevi D et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014; 514(7521):181-6
13.
Zurück zum Zitat Knight R, Callewaert C, Marotz C et al. The Microbiome and Human Biology. Annu Rev Genom Hum Genet. 2017;18:65-86 Knight R, Callewaert C, Marotz C et al. The Microbiome and Human Biology. Annu Rev Genom Hum Genet. 2017;18:65-86
14.
Zurück zum Zitat Rinninella E, Raoul P, Cintoni M et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. 2019;7(1):14 Rinninella E, Raoul P, Cintoni M et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. 2019;7(1):14
15.
Zurück zum Zitat Arumugam M, Raes J, Pelletier E et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174-80 Arumugam M, Raes J, Pelletier E et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174-80
16.
Zurück zum Zitat Quigley EMM. Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Nat Rev Gastroenterol Hepatol. 2017;14(5):315-20 Quigley EMM. Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Nat Rev Gastroenterol Hepatol. 2017;14(5):315-20
17.
Zurück zum Zitat Dogra SK, Doré J, Damak S. Gut Microbiota Resilience: Definition, Link to Health and Strategies for Intervention. Front Microbiol. 2020;11:572921 Dogra SK, Doré J, Damak S. Gut Microbiota Resilience: Definition, Link to Health and Strategies for Intervention. Front Microbiol. 2020;11:572921
18.
Zurück zum Zitat Rinninella E, Cintoni M, Raoul P et al. Food Components and Dietary Habits: Keys for a Healthy Gut Microbiota Composition. Nutrients. 2019;11:2393 Rinninella E, Cintoni M, Raoul P et al. Food Components and Dietary Habits: Keys for a Healthy Gut Microbiota Composition. Nutrients. 2019;11:2393
19.
Zurück zum Zitat Crommen S, Simon MC. Microbial Regulation of Glucose Metabolism and Insulin Resistance. Genes. 2018;9(1):10 Crommen S, Simon MC. Microbial Regulation of Glucose Metabolism and Insulin Resistance. Genes. 2018;9(1):10
20.
Zurück zum Zitat Simon MC, Strassburger K, Nowotny B et al. Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: A proof of concept. Diabetes Care. 2015;38(10):1827-34 Simon MC, Strassburger K, Nowotny B et al. Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: A proof of concept. Diabetes Care. 2015;38(10):1827-34
21.
Zurück zum Zitat Karlsson FH, Tremaroli V, Nookaew I et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013;498(7452):99-103 Karlsson FH, Tremaroli V, Nookaew I et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013;498(7452):99-103
22.
Zurück zum Zitat Vrieze A, van Nood E, Holleman F et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143(4):913-6.e7 Vrieze A, van Nood E, Holleman F et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143(4):913-6.e7
23.
Zurück zum Zitat Qin J, Li Y, Cai Z et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55-60 Qin J, Li Y, Cai Z et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55-60
24.
Zurück zum Zitat Knight I. The development and applications of sucralose, a new high-intensity sweetener. Can J Physiol Pharmacol. 1994;72(4):435-9 Knight I. The development and applications of sucralose, a new high-intensity sweetener. Can J Physiol Pharmacol. 1994;72(4):435-9
25.
Zurück zum Zitat Renwick AG. The disposition of saccharin in animals and man—A review. Food Chem Toxicol. 1985;23(4-5):429-35 Renwick AG. The disposition of saccharin in animals and man—A review. Food Chem Toxicol. 1985;23(4-5):429-35
26.
Zurück zum Zitat Butchko HH, Stargel WW, Comer CP et al. Aspartame: review of safety. Regul Toxicol Pharmacol. 2002;35(2):1-93 Butchko HH, Stargel WW, Comer CP et al. Aspartame: review of safety. Regul Toxicol Pharmacol. 2002;35(2):1-93
27.
Zurück zum Zitat Butchko H, Stargel W, Comer C et al. Aspartame. In: O'Brien NL (Hrsg.). Alternative Sweeteners. Boca Raton, FL: CRC Press, 2012:41-61 Butchko H, Stargel W, Comer C et al. Aspartame. In: O'Brien NL (Hrsg.). Alternative Sweeteners. Boca Raton, FL: CRC Press, 2012:41-61
28.
Zurück zum Zitat Abou-Donia MB, El-Masry EM, Abdel-Rahman AA et al. Splenda alters gut microflora and increases intestinal pglycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A. 2008;71(21):1415-29 Abou-Donia MB, El-Masry EM, Abdel-Rahman AA et al. Splenda alters gut microflora and increases intestinal pglycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A. 2008;71(21):1415-29
29.
Zurück zum Zitat Wang QP, Browman D, Herzog H, Neely GG. Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice. PloS one. 2018;13(7):e0199080 Wang QP, Browman D, Herzog H, Neely GG. Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice. PloS one. 2018;13(7):e0199080
30.
Zurück zum Zitat Bian X, Chi L, Gao B et al. Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice. Front Physiol. 2017;8:487 Bian X, Chi L, Gao B et al. Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice. Front Physiol. 2017;8:487
31.
Zurück zum Zitat Anderson RL, Kirkland JJ. The Effect of Sodium Saccharin in the diet on caecal microflora. Fd Cosmet Toxicol. 1980;18:353-5 Anderson RL, Kirkland JJ. The Effect of Sodium Saccharin in the diet on caecal microflora. Fd Cosmet Toxicol. 1980;18:353-5
32.
Zurück zum Zitat Palmnäs MSA, Cowan TE, Bomhof MR et al. Low-Dose Aspartame Consumption Differentially Affects Gut Microbiota-Host Metabolic Interactions in the Diet-Induced Obese Rat. PloS one. 2014;9(10):e109841 Palmnäs MSA, Cowan TE, Bomhof MR et al. Low-Dose Aspartame Consumption Differentially Affects Gut Microbiota-Host Metabolic Interactions in the Diet-Induced Obese Rat. PloS one. 2014;9(10):e109841
33.
Zurück zum Zitat Serrano J, Smith KR, Crouch AL et al. High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice. Microbiome. 2021;9(1):11 Serrano J, Smith KR, Crouch AL et al. High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice. Microbiome. 2021;9(1):11
34.
Zurück zum Zitat Thomson P, Santibañez R, Aguirre C et al. Short-term impact of sucralose consumption on the metabolic response and gut microbiome of healthy adults. Br J Nutr. 2019;122(8):856-62 Thomson P, Santibañez R, Aguirre C et al. Short-term impact of sucralose consumption on the metabolic response and gut microbiome of healthy adults. Br J Nutr. 2019;122(8):856-62
35.
Zurück zum Zitat Ahmad SY, Friel J, Mackay D. The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial. Nutrients. 2020;12(11):3408 Ahmad SY, Friel J, Mackay D. The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial. Nutrients. 2020;12(11):3408
36.
Zurück zum Zitat Suez J, Cohen Y, Valdés-Mas R et al. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. Cell. 2022;185(18):3307-3328.e19 Suez J, Cohen Y, Valdés-Mas R et al. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. Cell. 2022;185(18):3307-3328.e19
37.
Zurück zum Zitat Frankenfeld CL, Sikaroodi M, Lamb E et al. Highintensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. Ann Epidemiol. 2015;25(10):736-42.e4 Frankenfeld CL, Sikaroodi M, Lamb E et al. Highintensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. Ann Epidemiol. 2015;25(10):736-42.e4
38.
Zurück zum Zitat Skurk T, Bos-Westphal A, Grünerbel A et al. Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus. Diabetologie. 2021;16(Suppl 2):S255-89 Skurk T, Bos-Westphal A, Grünerbel A et al. Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus. Diabetologie. 2021;16(Suppl 2):S255-89
Metadaten
Titel
Effekte von Süßstoffverzehr bei Personen mit Diabetes mellitus
Süßstoffe - Modulatoren des Darmmikrobioms?
verfasst von
M. Sc. Linda Klümpen
Prof. Dr. med. Marie-Christine Simon
Publikationsdatum
24.10.2022
Verlag
Springer Medizin
Schlagwort
Clostridien
Erschienen in
Info Diabetologie / Ausgabe 5/2022
Print ISSN: 1865-5459
Elektronische ISSN: 2196-6362
DOI
https://doi.org/10.1007/s15034-022-4405-1

Weitere Artikel der Ausgabe 5/2022

Info Diabetologie 5/2022 Zur Ausgabe

Update Innere Medizin

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.