Electronic supplementary material
Sample size considerations
Neoadjuvant chemoradiation (arm A)
Neoadjuvant chemotherapy (Arm B)
Minimally invasive esophagectomy (Both arms)
♦ Pathological complete response rate(pCR): Pathological complete response rate (pCR) is to be assessed in the resected specimen following neoadjuvant therapy using standardized work up of the resection specimen in the pathology department and standardized histological criteria for tumor regression grading. The degree of histomorphologic regression is clarified into four categories as follows: grade 1, no evidence of vital residual tumor cells (pathological complete response); grade 2, less than 10% vital residual tumor cells; grade 3, 10 to 50%; and grade 4, more than 50% according to previous report .
♦ R0 resection rate: No vital tumor is presented at the proximal, distal, or circumferential resection margin, then it is considered to be R0 resection. If a vital tumor is shown at 1 mm or less from the proximal, distal, or circumferential resection margin, it is considered to be microscopically positive (R1).
♦ Positive lymph nodes’ number: According to pathological reports, record the number of positive lymph nodes.
♦ Postoperative TNM stage according to the UICC TNM7 system .