Skip to main content
Erschienen in: Intensive Care Medicine 6/2012

01.06.2012 | Original

Coagulation Day 2010: an Austrian survey on the routine of thromboprophylaxis in intensive care

verfasst von: E. Schaden, P. G. Metnitz, G. Pfanner, S. Heil, T. Pernerstorfer, P. Perger, H. Schoechl, D. Fries, M. Guetl, S. Kozek-Langenecker

Erschienen in: Intensive Care Medicine | Ausgabe 6/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Venous thromboembolism (VTE) is a common but often overlooked life-threatening complication of critical illness. The aim of this cross-sectional survey was to assess current practice of thromboprophylaxis as well as adherence to international guidelines.

Methods

After ethics committee approval, all intensive care units in Austrian hospitals treating adult patients were invited to participate in this web-based survey. Anonymized data on each patient treated at the participating intensive care units on Coagulation Day 2010 were collected using an electronic case report form. Risk assessment, choice and monitoring of anticoagulants, means of mechanical prophylaxis, and demographic data were recorded.

Results

Data from 325 critically ill patients were collected. Patients had a median of four risk factors for thrombosis and 6 % suffered from VTE. Of the 325 patients, 80 % received low molecular weight heparins subcutaneously, 10 % received unfractionated heparin intravenously, 1 % received alternative anticoagulants and 9 % received no pharmacological prophylaxis. Mechanical prophylaxis was used in 49 % with a predominant use of graduated compression stockings. In 39 % a combination of pharmacological and mechanical prophylaxis was applied and 5 % received no prophylaxis at all. Overall guideline adherence was 40 % on Coagulation Day 2010.

Conclusion

Current practice of thromboprophylaxis is predominantly based on the administration of low molecular weight heparins prescribed at rather arbitrary doses without a discernible relationship to drug monitoring, thromboembolic risk factors, vasopressor use or fluid balance. The use of mechanical prophylaxis, evaluation of risk scores and overall guideline adherence must be further encouraged by education, training and communication.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Levi M (2008) Hemostasis and thrombosis in critically ill patients. Semin Thromb Hemost 34:415–416PubMedCrossRef Levi M (2008) Hemostasis and thrombosis in critically ill patients. Semin Thromb Hemost 34:415–416PubMedCrossRef
2.
Zurück zum Zitat Hirsh J, Guyatt G, Albers GW, Harrington R, Schünemann HJ; American College of Chest Physicians (2008) Antithrombotic and thrombolytic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133(6 Suppl):110S–112SPubMedCrossRef Hirsh J, Guyatt G, Albers GW, Harrington R, Schünemann HJ; American College of Chest Physicians (2008) Antithrombotic and thrombolytic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133(6 Suppl):110S–112SPubMedCrossRef
3.
Zurück zum Zitat Anderson FA Jr, Spencer FA (2003) Risk factors for venous thromboembolism. Circulation 107(23 Suppl 1):I9–16PubMed Anderson FA Jr, Spencer FA (2003) Risk factors for venous thromboembolism. Circulation 107(23 Suppl 1):I9–16PubMed
4.
Zurück zum Zitat Cushman M (2007) Epidemiology and risk factors for venous thrombosis. Semin Hematol 44:62–69PubMedCrossRef Cushman M (2007) Epidemiology and risk factors for venous thrombosis. Semin Hematol 44:62–69PubMedCrossRef
5.
Zurück zum Zitat Dörffler-Melly J, de Jonge E, Pont AC, Meijers J, Vroom MB, Büller HR, Levi M (2002) Bioavailability of subcutaneous low-molecular-weight heparin to patients on vasopressors. Lancet 359:849–850PubMedCrossRef Dörffler-Melly J, de Jonge E, Pont AC, Meijers J, Vroom MB, Büller HR, Levi M (2002) Bioavailability of subcutaneous low-molecular-weight heparin to patients on vasopressors. Lancet 359:849–850PubMedCrossRef
6.
Zurück zum Zitat Rommers MK, Van der Lely N, Egberts TC, van den Bemt PM (2006) Anti-Xa activity after subcutaneous administration of dalteparin in ICU patients with and without subcutaneous oedema: a pilot study. Crit Care 10:R93PubMedCrossRef Rommers MK, Van der Lely N, Egberts TC, van den Bemt PM (2006) Anti-Xa activity after subcutaneous administration of dalteparin in ICU patients with and without subcutaneous oedema: a pilot study. Crit Care 10:R93PubMedCrossRef
8.
Zurück zum Zitat Cohen AT, Agnelli G, Anderson FA, Arcelus JI, Bergqvist D, Brecht JG, Greer IA, Heit JA, Hutchinson JL, Kakkar AK, Mottier D, Oger E, Samama MM, Spannagl M; VTE Impact Assessment Group in Europe (VITAE) (2007) Venous thromboembolism (VTE) in Europe: the number of VTE events and associated morbidity and mortality. Thromb Haemost 98:756–764PubMed Cohen AT, Agnelli G, Anderson FA, Arcelus JI, Bergqvist D, Brecht JG, Greer IA, Heit JA, Hutchinson JL, Kakkar AK, Mottier D, Oger E, Samama MM, Spannagl M; VTE Impact Assessment Group in Europe (VITAE) (2007) Venous thromboembolism (VTE) in Europe: the number of VTE events and associated morbidity and mortality. Thromb Haemost 98:756–764PubMed
9.
Zurück zum Zitat Crowther MA, Cook DJ (2008) Preventing venous thromboembolism in critically ill patients. Semin Thromb Hemost 34:469–474PubMedCrossRef Crowther MA, Cook DJ (2008) Preventing venous thromboembolism in critically ill patients. Semin Thromb Hemost 34:469–474PubMedCrossRef
10.
Zurück zum Zitat Lacherade JC, Cook D, Heyland D, Chrusch C, Brochard L, Brun-Buisson C; French and Canadian ICU Directors Groups (2003) Prevention of venous thromboembolism in critically ill medical patients: a Franco-Canadian cross-sectional study. J Crit Care 18:228–237PubMedCrossRef Lacherade JC, Cook D, Heyland D, Chrusch C, Brochard L, Brun-Buisson C; French and Canadian ICU Directors Groups (2003) Prevention of venous thromboembolism in critically ill medical patients: a Franco-Canadian cross-sectional study. J Crit Care 18:228–237PubMedCrossRef
11.
Zurück zum Zitat Imberti D, Ageno W (2005) A survey of thromboprophylaxis management in patients with major trauma. Pathophysiol Haemost Thromb 34:249–254PubMedCrossRef Imberti D, Ageno W (2005) A survey of thromboprophylaxis management in patients with major trauma. Pathophysiol Haemost Thromb 34:249–254PubMedCrossRef
12.
Zurück zum Zitat Kakkos SK, Caprini JA, Geroulakos G, Nicolaides AN, Stansby GP, Reddy DJ (2008) Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism in high-risk patients. Cochrane Database Syst Rev 4:CD005258 Kakkos SK, Caprini JA, Geroulakos G, Nicolaides AN, Stansby GP, Reddy DJ (2008) Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism in high-risk patients. Cochrane Database Syst Rev 4:CD005258
13.
Zurück zum Zitat Sachdeva A, Dalton M, Amaragiri SV, Lees T (2010) Elastic compression stockings for prevention of deep vein thrombosis. Cochrane Database Syst Rev 7:CD001484PubMed Sachdeva A, Dalton M, Amaragiri SV, Lees T (2010) Elastic compression stockings for prevention of deep vein thrombosis. Cochrane Database Syst Rev 7:CD001484PubMed
14.
Zurück zum Zitat Fritz E, Them C, Hackl JM (2005) Routine nursing measures for thrombosis prevention in an university hospital. Pflege 18:43–50PubMedCrossRef Fritz E, Them C, Hackl JM (2005) Routine nursing measures for thrombosis prevention in an university hospital. Pflege 18:43–50PubMedCrossRef
15.
Zurück zum Zitat Eisele R, Kinzl L, Koelsch T (2007) Rapid-inflation intermittent pneumatic compression for prevention of deep venous thrombosis. J Bone Joint Surg Am 89:1050–1056PubMedCrossRef Eisele R, Kinzl L, Koelsch T (2007) Rapid-inflation intermittent pneumatic compression for prevention of deep venous thrombosis. J Bone Joint Surg Am 89:1050–1056PubMedCrossRef
16.
Zurück zum Zitat Robinson S, Zincuk A, Strøm T, Larsen TB, Rasmussen B, Toft P (2010) Enoxaparin, effective dosage for intensive care patients: double-blinded, randomised clinical trial. Crit Care 14:R41PubMedCrossRef Robinson S, Zincuk A, Strøm T, Larsen TB, Rasmussen B, Toft P (2010) Enoxaparin, effective dosage for intensive care patients: double-blinded, randomised clinical trial. Crit Care 14:R41PubMedCrossRef
17.
18.
Zurück zum Zitat Bara L, Leizorovicz A, Picolet H, Samama MM (1992) Correlation between anti-Xa and occurrence of thrombosis and haemorrhage in post-surgical patients treated with either Logiparin (LMWH) or unfractionated heparin. Post-surgery Logiparin Study Group. Thromb Res 65:641–650PubMedCrossRef Bara L, Leizorovicz A, Picolet H, Samama MM (1992) Correlation between anti-Xa and occurrence of thrombosis and haemorrhage in post-surgical patients treated with either Logiparin (LMWH) or unfractionated heparin. Post-surgery Logiparin Study Group. Thromb Res 65:641–650PubMedCrossRef
19.
Zurück zum Zitat Leizorovicz A, Bara L, Samama MM, Haugh MC (1993) Factor Xa inhibition: correlation between the plasma levels of anti-Xa activity and occurrence of thrombosis and haemorrhage. Haemostasis 23(Suppl 1):89–98PubMed Leizorovicz A, Bara L, Samama MM, Haugh MC (1993) Factor Xa inhibition: correlation between the plasma levels of anti-Xa activity and occurrence of thrombosis and haemorrhage. Haemostasis 23(Suppl 1):89–98PubMed
20.
Zurück zum Zitat Bara L, Planes A, Samama MM (1999) Occurrence of thrombosis and haemorrhage, relationship with anti-Xa, anti-IIa activities, and D-dimer plasma levels in patients receiving a low molecular weight heparin, enoxaparin or tinzaparin, to prevent deep vein thrombosis after hip surgery. Br J Haematol 104:230–240PubMedCrossRef Bara L, Planes A, Samama MM (1999) Occurrence of thrombosis and haemorrhage, relationship with anti-Xa, anti-IIa activities, and D-dimer plasma levels in patients receiving a low molecular weight heparin, enoxaparin or tinzaparin, to prevent deep vein thrombosis after hip surgery. Br J Haematol 104:230–240PubMedCrossRef
21.
Zurück zum Zitat Levine MN, Hirsh J, Gent M, Turpie AG, Cruickshank M, Weitz J, Anderson D, Johnson M (1994) A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin. Arch Intern Med 154:49–56PubMedCrossRef Levine MN, Hirsh J, Gent M, Turpie AG, Cruickshank M, Weitz J, Anderson D, Johnson M (1994) A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin. Arch Intern Med 154:49–56PubMedCrossRef
22.
Zurück zum Zitat Levy JH, Key NS, Azran MS (2010) Novel oral anticoagulants: implications in the perioperative setting. Anesthesiology 113:726–745PubMed Levy JH, Key NS, Azran MS (2010) Novel oral anticoagulants: implications in the perioperative setting. Anesthesiology 113:726–745PubMed
23.
Zurück zum Zitat Schaden E, Schober A, Hacker S, Spiss C, Chiari A, Kozek-Langenecker S (2010) Determination of enoxaparin with rotational thrombelastometry using the prothrombinase-induced clotting time reagent. Blood Coagul Fibrinolysis 21:256–261PubMedCrossRef Schaden E, Schober A, Hacker S, Spiss C, Chiari A, Kozek-Langenecker S (2010) Determination of enoxaparin with rotational thrombelastometry using the prothrombinase-induced clotting time reagent. Blood Coagul Fibrinolysis 21:256–261PubMedCrossRef
24.
Zurück zum Zitat Cook DJ, Crowther MA, Meade MO, Douketis J (2005) Prevalence, incidence, and risk factors for venous thromboembolism in medical-surgical intensive care unit patients. J Crit Care 20:309–313PubMedCrossRef Cook DJ, Crowther MA, Meade MO, Douketis J (2005) Prevalence, incidence, and risk factors for venous thromboembolism in medical-surgical intensive care unit patients. J Crit Care 20:309–313PubMedCrossRef
25.
Zurück zum Zitat Hilbert P, Teumer P, Stuttmann R (2008) Prevention of thromboembolism in German intensive care units: results of a nationwide survey. Anaesthesist 57:242–250PubMedCrossRef Hilbert P, Teumer P, Stuttmann R (2008) Prevention of thromboembolism in German intensive care units: results of a nationwide survey. Anaesthesist 57:242–250PubMedCrossRef
Metadaten
Titel
Coagulation Day 2010: an Austrian survey on the routine of thromboprophylaxis in intensive care
verfasst von
E. Schaden
P. G. Metnitz
G. Pfanner
S. Heil
T. Pernerstorfer
P. Perger
H. Schoechl
D. Fries
M. Guetl
S. Kozek-Langenecker
Publikationsdatum
01.06.2012
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 6/2012
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-012-2533-0

Weitere Artikel der Ausgabe 6/2012

Intensive Care Medicine 6/2012 Zur Ausgabe

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.