No competing financial or non-financial interests exist.
CKY participated in conduct and design of the study and data analyses, drafted and revised the manuscript. FTB conducted the data analysis and participated in drafting the manuscript and revising it critically for important intellectual content. AJC was responsible for sample analysis and assay development. BR participated in drafting the manuscript and revising it critically for important intellectual content. LL and MBS were critical in conducting the study. SA provided technical support and participated in study conduct and design. BS conducted laboratory analyses and provided critical intellectual content. DDS and TAI provided oversight, assisted with conduct and design of the study, and revised the drafted manuscript for important intellectual content. JH conceptualized the study, provided oversight for the study design and conduct, and participated in drafting the manuscript and revising it critically for important intellectual content. All authors read and approved the final manuscript.
Coenzyme Q10 (CoQ10) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity in patients with congestive heart failure. There are no studies evaluating the safety, tolerability and efficacy of varying doses of CoQ10 in chronic hemodialysis patients, a population subject to increased oxidative stress.
We performed a dose escalation study to test the hypothesis that CoQ10 therapy is safe, well-tolerated, and improves biomarkers of oxidative stress in patients receiving hemodialysis therapy. Plasma concentrations of F2-isoprostanes and isofurans were measured to assess systemic oxidative stress and plasma CoQ10 concentrations were measured to determine dose, concentration and response relationships.
Fifteen of the 20 subjects completed the entire dose escalation sequence. Mean CoQ10 levels increased in a linear fashion from 704 ± 286 ng/mL at baseline to 4033 ± 1637 ng/mL, and plasma isofuran concentrations decreased from 141 ± 67.5 pg/mL at baseline to 72.2 ± 37.5 pg/mL at the completion of the study (P = 0.003 vs. baseline and P < 0.001 for the effect of dose escalation on isofurans). Plasma F2-isoprostane concentrations did not change during the study.
CoQ10 supplementation at doses as high as 1800 mg per day was safe in all subjects and well-tolerated in most. Short-term daily CoQ10 supplementation decreased plasma isofuran concentrations in a dose dependent manner. CoQ10 supplementation may improve mitochondrial function and decrease oxidative stress in patients receiving hemodialysis.
This clinical trial was registered on clinicaltrials.gov [NCT00908297] on May 21, 2009.
U S Renal Data System, USRDS. Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2013. www.usrds.org.
MEDPAC. A Data Book: Healthcare Spending and the Medicare Program. 2009.
Fessel JP, Porter NA, Moore KP, Sheller JR, Roberts 2nd LJ. Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc Natl Acad Sci U S A. 2002;99(26):16713–8. doi: 10.1073/pnas.252649099. CrossRefPubMedPubMedCentral
Claessens AJ, Yeung CK, Risler LJ, Phillips BR, Himmelfarb J, Shen DD. Rapid and sensitive analysis of reduced and oxidized coenzyme Q10 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and application to studies in healthy human subjects. Ann Clin Biochem. 2015.
Billings FT 4th. Intraoperative normoxia, oxidative damage, and organ injury following cardiac surgery. Shock. 2015;43(S1):24.
Singh RB, Kumar A, Niaz MA, Singh RG, Gujrati S, Singh VP, et al. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in patients with End-stage renal failure. J Nutr Environ Med. 2003;13(1):13–22. CrossRef
von Eckardstein A, Walter M, Holz H, Benninghoven A, Assmann G. Site-specific methionine sulfoxide formation is the structural basis of chromatographic heterogeneity of apolipoproteins A-I, C-II, and C-III. J Lipid Res. 1991;32(9):1465–76.
- Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress
Catherine K. Yeung
Frederic T. Billings IV
Adam J. Claessens
Mary B. Sundell
Danny D. Shen
T. Alp Ikizler
- BioMed Central
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