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Medical Microbiology and Immunology

Erschienen in:

25.02.2019 | Review

Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway

verfasst von: Markus Stempel, Baca Chan, Melanie M. Brinkmann

Erschienen in: Medical Microbiology and Immunology | Ausgabe 3-4/2019

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Abstract

Early detection of viral invasion by pattern recognition receptors (PRR) is crucial for the induction of a rapid and efficient immune response. Cytosolic DNA sensors are the most recently described class of PRR, and induce transcription of type I interferons (IFN) and proinflammatory cytokines via the key adaptor protein stimulator of interferon genes (STING). Herpesviruses are a family of large DNA viruses widely known for their immense arsenal of proteins dedicated to manipulating and evading host immune responses. Tantamount to the significant role played by DNA sensors and STING in innate immune responses, herpesviruses have in turn evolved a range of mechanisms targeting virtually every step of this key signaling pathway. Strikingly, some herpesviruses also take advantage of this pathway to promote their own replication. In this review, we will summarize the current understanding of DNA sensing and subsequent induction of signaling and transcription, and showcase the close adaptation of herpesviruses to their host reflected by the myriad of viral proteins dedicated to modulating this critical innate immune pathway.

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Titel: Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway
verfasst von: Markus Stempel
Baca Chan
Melanie M. Brinkmann
Publikationsdatum: 25.02.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Medical Microbiology and Immunology / Ausgabe 3-4/2019
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-019-00582-0

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Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway

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