Introduction
Methods
Study Eligibility Criteria
Study Identification and Selection Process
Data Collection and Data Items
Risk of Bias Assessment in Individual Studies
Individual Patient Data Meta-Analysis
Study | Type of addiction (N) | Age / gender | CBM intervention | Control condition | Training schedule | Task stimuli | Cognitive Bias assessment | Substance use assessment | Relapse assessment | Setting | Completer rate |
---|---|---|---|---|---|---|---|---|---|---|---|
Begh et al. 2015 | Tobacco (N = 118a adult smokers, recruited in stop smoking services and medical general practices) | Mean age = 44.8, SD = 12.7; 69 (58%) females | AtBM + TAU (smoking cessation program); VPT, probe replaced neutral pictures (100%) n = 60 | Active: sham AtBM training + TAU (smoking cessation program); VPT, probe replaced smoking or neutral pictures (50%) n = 58 | 1 session x week for 5 weeks 192 training trials x session | 18 matched pairs of smoking-related pictures (smoking related objects and people smoking cigarettes) and control pictures (everyday objects, such as staplers or keys, and people engaged in everyday activities, such as using the phone) | Measures: visual Stroop task, VPT Time points: baseline, 1, 5, 9, and 10 weeks after end of training | _ | Measures: electronic diary, exhaled carbon monoxide Time points: baseline, each training session, 1, 5, 9 and 10 weeks after end of training | Supervised in smoking clinic | 73% at 1 week, 75% at 5 weeks, 69% at 9 weeks, and 64% at 10 weeks after end of training |
Clerkin et al. 2016 | Alcohol (N = 86 community-recruited adult heavy drinkers with elevated social anxiety symptoms) | Mean age = 44.3, SD = 10.9; 35 (41%) females | AtBM + real or sham social AtBM training for social anxiety (factorial design); VPT, probe replaced neutral pictures (100%) + positive feedback on response accuracy and RT n = 42 | Active: sham AtBM training + real or sham AtBM training for social anxiety; VPT, probe replaced alcohol or neutral pictures (50%) n = 44 | 2 sessions x week for 4 weeks (max 6 weeks) 144 training trials x session | 60 pairs of matched alcohol-related pictures (alcoholic drinks) and neutral pictures (non-alcoholic drinks, including water and other drinks). All pictures include both passive (beverage only) and active (person drinking) contexts | Measures: VPT Time points: baseline, 1 and 4 weeks after end of training | Measures: Daily Drinking Questionnaire (total amount of drinks in the past week) Time points: baseline, 1 and 4 weeks after end of training | _ | Supervised in research lab | 81% at 1 and 4 weeks after end of training |
Cox et al. 2015 | Alcohol (N = 148 community-recruited, adult at-risk drinkers) | Mean age = 28.8, SD = 14.4; 140 (57%) females | AtBM with or without group motivational workshops (LEAP; factorial design); AACTP paradigm n = 77 | Inactive: no training with or without LEAP) | 1 session x week for 4 weeks 500 training trials x session | Alcohol-related pictures (bottles of alcoholic drinks) Neutral pictures (bottles of soft-drinks) | – | Measures: Drinking Record Questionnaire (quantity and frequency of drinking in past 12 weeks; mean weekly drinking index) Time points: baseline, immediately and 12 and 24 weeks after end of training | – | Supervised in research lab | 79% at post-training, 59% at 12 weeks and 47% at 24 weeks after end of training |
Eberl et al. 2013 | Alcohol (N = 475b alcohol dependent adult inpatients) | Mean age = 46, SD = 9; 118 (25%) females | ApBM + TAU (CBT-based residential treatment); AAT, alcohol stimuli presented in push format (100%) n = 248 | Inactive: no training + TAU (CBT-based treatment) n = 227 | 2 sessions x week for 6 weeks 200 training trials x session | 20 alcohol-related pictures (familiar common alcoholic drinks) 20 neutral pictures (familiar common soft-drinks) | Measures: AAT, VPT Time points: baseline, start of each training session, end of training | – | Measures: Self-reported abstinence Time points: 12 months after discharge | Supervised in residential clinic | AAT: 71% at baseline, 72% at post-training. Relapse: 75% at 12 months after discharge |
Elfeddali et al. 2016 | Tobacco (N = 434, online-recruited adult smokers, actively confirming a quit-attempt after baseline) | Mean age = 40.8, SD = 11; 299 (69%) females | AtBM; VPT, probe replaced neutral pictures (100%) n = 224 | Active: sham AtBM training; VPT, probe replaced smoking or neutral pictures (50%) n = 210 | 2 sessions x week for 3 weeks (max 4 weeks) 240 training trials x session | 96 matched pairs of smoking-related pictures (e.g., cigarette packs, smoking people) and neutral pictures (e.g., pencil packages, non-smoking people) | Measures: VPT, AAT Time points: baseline, immediately after end of training, and 6 months after baseline. | – | Measures: self-reported smoking abstinence Time points: 6 months after baseline | Unsupervised, online intervention | 48% at post-training, 31% at 6 months after baseline |
Kong et al. 2015 | Tobacco (N = 60 adolescent smokers recruited in high schools in the US and NL) | Mean age = 17, SD = 1.2; 21 (35%) females | ApBM + TAU (CBT for smoking cessation); AAT, smoking stimuli presented in push format (100%) n = 29 | Active: sham ApBM training + TAU (CBT for smoking cessation); AAT, smoking and control stimuli presented in push and pull format equally often n = 31 | 1 session x week for 4 weeks 300 training trials x session | 20 smoking-related pictures (e.g., cigarettes, cigarette packs, adolescents smoking) 20 neutral pictures (e.g., pencil, lipsticks) | Measures: AAT Time points: baseline and 12 weeks after end of treatment | – | Measures: 7-days self-reported smoking abstinence verified through measure of cotinine levels. Time points: immediately and 12 weeks after end of treatment. | Supervised in schools (individual sessions) | 32% at end of treatment and 58% at 12 weeks after end of treatment |
Lopes et al. 2014 | Tobacco (N = 67 adult smokers recruited from university staff and students enrolled in smoking cessation program) | Mean age 45.1; SD = 12.2; 42 (63%) females | 1. 3 sessions AtBM + TAU (group CBT for smoking cessation); probe replaced neutral pictures (100%) n = 22 2. 1 session AtBM +2 sessions sham training + TAU VPT, probe replaced neutral pictures (100%) n = 22 | Active: sham AtBM training + TAU (group CBT for smoking cessation); 1 session VPT, probe replaced smoking or neutral pictures (50%), with different set of smoking stimuli; 2 sessions VPT with neutral stimuli n = 23 | 3 sessions over first 2 weeks of TAU 576 training trials per session | 48 pairs of matched smoking-related (e.g., cigarette packs, lighter) and neutral pictures (e.g., wallet, cell phone) + 24 pairs of neutral pictures taken from the IAPS database for the control condition | Measures: VPT (50, 500, 2000 ms SOAs)c Time points: baseline, 24 h, 4 weeks, 6 and 12 months after the end of training | Measures: self-reported number of cigarettes smoked/day, exhaled carbon monoxide Time points: baseline, 24 h, 4 weeks, 6 and 12 months after the end of training | Measures: self-reported continued smoking Time points: baseline, 24 h, 4 weeks, 6 and 12 months after the end of training | Supervised in research lab | 100% at 24 h, 75% at 1, 6 and 12 months after end of training |
Machulska et al. 2016 | Tobacco (N = 139d adult smokers recruited in inpatient rehab clinic) | Mean age = 42.7, SD = 10.4; 37 (27%) females | ApBM + TAU (3 sessions motivational interviewing and psychoeducation); AAT, smoking stimuli presented in push format (100%) n = 73 | Active: sham ApBM training + TAU (3 sessions motivational interviewing and psychoeducation; AAT, smoking and control stimuli presented in push and pull format equally often n = 66 | 1 session x day for 4 Days 250 training trials x session | 15 smoking-related pictures depicting models at stages of smoking rituals (e.g., taking a cigarette our of the pack, lighting a cigarette, killing a cigarette) 15 neutral pictures depicting models at different stages of tooth brushing (e.g., preparing toothbrush with toothpaste, putting toothbrush in the mouth) | Measures: AAT Time points: baseline, immediately after end of training | Measures: self-reported number of cigarettes/day Time points: baseline and 12 weeks after end of training | – | Supervised in clinic | 76% immediately after the end of training. No attrition data available for the 12-week follow-up |
McHugh et al. 2010 | Tobacco (N = 50 community-recruited adult smokers)e | Mean age = 37.9, SD = 13.8; 18 (35%) females | AtBM; VPT, probe replaced neutral pictures in most of the trials (85%) | Active: sham AtBM training; VPT, probe replaced smoking or neutral pictures (50%) | 1 session 560 training trials | 20 pairs of matched smoking-related pictures (smoking-related scenes, such as woman holding cigarette to mouth, cigarette beside ashtray) and neutral pictures (e.g., e.g. woman applying lipstick, pen beside bowl) | Measures: VPT Time points: baseline, immediately after end of training | – | – | Supervised in research lab | 100% at end of training. |
Schoenmakers et al. 2010 | Alcohol (n = 43 alcohol-dependentadult in- and outpatients) | Mean age = 45, SD = 9.8; 10 (23%) females | AtBM + TAU (CBT); VPT, probe replaced neutral pictures (100%) + positive feedback on response accuracy and RT n = 21 | Active: placebo training + TAU (CBT); categorization task, same stimuli used in AtBM training n = 22 | 5 sessions over 3 weeks (2 x week) 528 training trials x session | 60 pairs of matched alcohol-related pictures (e.g., alcohol drinks and objects) and neutral pictures (e.g., soft-drinks, furniture and stationary) | Measures: VPT (trained and untrained alcohol stimuli at post-training) Time points: baseline, 3–4 days after end of training | – | Measures: self-reported abstinence confirmed by medical record Time points: 12 weeks after end of training | Supervised in clinic | 86% immediately and 81% at 12 weeks after end of training |
Alcohol (N = 32f alcohol dependent adult inpatients) | Mean age = 44, SD = 7.6; 32 (100%) males | ApBM + TAU (CBT-based residential treatment); AAT, alcohol stimuli presented in push format (90%) and neutral stimuli in pull format (90%) n = 15 | Active: sham ApBM training; AAT, alcohol and control stimuli presented in push and pull format equally often n = 17 | 2 x week for 3 weeks 400 training trials x session | 40 alcohol-related pictures (familiar common alcoholic drinks) 40 neutral pictures (familiar common soft-drinks) | Measures: AAT Time points: baseline and immediately after end of training | – | Measures self-reported abstinence (not part of the final report) Time points: 12 months after discharge from the clinic | Supervised in clinic | AAT: 100% after end of treatment Relapse: 84% after 12 months from discharge from the clinic | |
Wiers et al. 2011 | Alcohol (N = 214 alcohol dependent adult inpatients) | Mean age = 45.3, SD = 8; 52 (24%) females | 1. ApBM + TAU (CBT-based residential treatment); AAT, alcohol stimuli presented in push format (100%); explicit instructions to react to alcohol and non-alcohol stimuli n = 56 2. ApBM + TAU; AAT, alcohol stimuli presented in push format (100%); implicit instructions to react to stimulus format n = 52g | 1. Active: sham ApBM training + TAU (CBT-based residential treatment); AAT, alcohol and control stimuli presented in push and pull format equally often n = 55 2. Inactive: waiting list + TAU n = 51g | 1 x day for 4 days 200 training trials x session | 20 alcohol-related pictures (familiar common alcoholic drinks) 20 neutral pictures (familiar common soft-drinks) | Measures: AAT (trained and untrained stimuli at post-training), approach-avoidance IAT Time points: baseline, 1 weeks after end of training | – | Measures: self-reported abstinence Time points: 12 months after discharge from the clinic | Supervised in clinic | AAT: 86% at baseline (11 participants excluded for excessive error rate); 89% at 1 week after end of training (6 participants excluded for excessive error rate) IAT: 91% baseline and 93% 1 week after end of training Relapse: 87% at 12 months after discharge |
Alcohol (N = 615 online recruited adult problem drinkers; data available for 312 participants (51%) who initiated the baseline) | Mean age = 45.9, SD = 11.2; 144 (46%) femalesh | 1. AtBM; AACTP paradigm n = 56i 2. ApBM; AAT, alcohol stimuli presented in push format (100%); explicit instructions to react to alcohol and non-alcohol stimuli n = 57 3. ApBM; AAT, alcohol stimuli presented in push format (100%); implicit instructions to react to stimulus format n = 67 4. ApBM; AAT, alcohol stimuli presented in push format (90%); implicit instructions to react to stimulus format n = 77l | 1. Active: sham ApBM training; AAT alcohol and control stimuli presented in push and pull format equally often n = 55 | 4 sessions (max 14-day interval between sessions) AACTP: 200 training trials per session AAT: 220 training trials x session | Alcohol-related pictures (alcoholic drinks) and neutral pictures (non-alcoholic drinks, such as soft-drinks and water) | Measures: SRC Time points: baseline, 2 weeks after end of training | Measures: Time Line Follow Back (mean weekly drinking in the past two weeks) Time points: baseline, 2, 6 and 13 weeks after end of training | – | Unsupervised, online intervention | Completers: 22% 2 weeks, 18% 6 weeks, and 14% 13 weeks after the end of training | |
Wittekind et al. 2015 | Tobacco (N = 257 adult heavy smokers recruited in online smoking-related forums) | Mean age = 43.2, SD = 11; 157 (61%) females | 1. ApBM; AAT, alcohol stimuli presented in push format (100%); n = 87 2. ApBM; AAT, alcohol stimuli presented in push format (100%) + feedback on RT n = 85l | Inactive: waiting list n = 85 | 1 session 100 training trials | 10 pairs of matched smoking-related pictures (e.g., smoking packs, smoking scenes) and neutral pictures (everyday scenes and objects) | – | Measures: self-reported amount of cigarettes/day Time points: baseline, 4 weeks after baseline | – | Unsupervised, online intervention | 61% at four weeks after baseline |