Skip to main content

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Behavioral and Brain Functions 1/2017

Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine

Behavioral and Brain Functions > Ausgabe 1/2017
Radu Ionita, Paula Alexandra Postu, Galba Jean Beppe, Marius Mihasan, Brindusa Alina Petre, Monica Hancianu, Oana Cioanca, Lucian Hritcu



Plants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun. Markhamia tomentosa (Benth.) K. Schum. (Bignoniaceae) is used as an antimalarial, anti-inflammatory, analgesic, antioxidant and anti-Alzheimer agent. The current study was undertaken in order to investigate its anti-amnesic and antioxidant potential on scopolamine-induced cognitive impairment and to determine its possible mechanism of action.


Rats were pretreated with the aqueous extract (50 and 200 mg/kg, p.o.), for 10 days, and received a single injection of scopolamine (0.7 mg/kg, i.p.) before training in Y-maze and radial arm-maze tests. The biochemical parameters in the rat hippocampus were also assessed to explore oxidative status. Statistical analyses were performed using two-way ANOVA followed by Tukey’s post hoc test. F values for which p < 0.05 were regarded as statistically significant.


In the scopolamine-treated rats, the aqueous extract improved memory in behavioral tests and decreased the oxidative stress in the rat hippocampus. Also, the aqueous extract exhibited anti-acetylcholinesterase activity.


These results suggest that the aqueous extract ameliorates scopolamine-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2017

Behavioral and Brain Functions 1/2017 Zur Ausgabe

Neu in den Fachgebieten Neurologie und Psychiatrie