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Erschienen in: Brain Structure and Function 7/2021

27.06.2021 | Review

Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net

verfasst von: Ellie A. Bucher, Jessica M. Collins, Anna E. King, James C. Vickers, Matthew T. K. Kirkcaldie

Erschienen in: Brain Structure and Function | Ausgabe 7/2021

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Abstract

The calcium binding protein parvalbumin is expressed in interneurons of two main morphologies, the basket and chandelier cells, which target perisomatic domains on principal cells and are extensively interconnected in laminar networks by synapses and gap junctions. Beyond its utility as a convenient cellular marker, parvalbumin is an unambiguous identifier of the key role that these interneurons play in the fundamental functions of the cortex. They provide a temporal framework for principal cell activity by propagating gamma oscillation, providing coherence for cortical information processing and the basis for timing-dependent plasticity processes. As these parvalbumin networks mature, they are physically and functionally stabilised by axonal myelination and development of the extracellular matrix structure termed the perineuronal net. This maturation correlates with the emergence of high-speed, highly energetic activity and provides a coherent foundation for the unique ability of the cortex to cross-correlate activity across sensory modes and internal representations.
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Metadaten
Titel
Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net
verfasst von
Ellie A. Bucher
Jessica M. Collins
Anna E. King
James C. Vickers
Matthew T. K. Kirkcaldie
Publikationsdatum
27.06.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 7/2021
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-021-02327-3