Antimicrobial resistance is a multi-sectoral problem which is now recognized as one of the most serious threats to human health globally. Resistance trends among Enterobacteriaceae are especially worrisome considering their ubiquity in the environment and animal systems, and their enhanced propensity to acquire antibiotic resistance determinants through mobile genetic elements. Indiscriminate use of antibiotics is mainly responsible for the emergence of Enterobacteriaceae resistant to multiple antibiotics including carbapenems.
Colistin, a cationic polypeptide, is considered as one of the last-resort drugs of choice for the treatment of multi-drug resistant, Gram negative bacteria such as carbapenem resistant
Enterobacteriaceae (CRE). Present day increase in the incidences of multi-drug resistant bacteria has resulted in enhanced use of colistin globally, with an inevitable risk of emerging resistance. A study in Vietnam has shown increasing resistance in commensal
Escherichia coli associated with the extensive use of colistin in livestock and poultry industry [
1]. A recent study has shown colistin sulfate to be the most commonly used antibiotic in poultry industry in Bangladesh [
2]. Acquired resistance to colistin is generally associated with chromosomal mutations [
3], although a new plasmid-mediated transferable resistance determinant, the
mcr-
1 gene, encoding a phosphoethanolamine transferase, has been described recently in China [
4]. Since the plasmid encoding
mcr-
1 has been established as a marker for colistin resistance,
Enterobacteriaceae carrying this gene has been reported from many parts of the world [
5]. Considering the widespread occurrence of colistin resistance and the impending danger associated with it, we screened bacteria belonging to the family
Enterobacteriaceae isolated from sludge samples of Dhaka city for their resistance to colistin and for the presence of colistin resistance-related gene
mcr-
1. Here we report the occurrence of colistin resistant
E. coli carrying
mcr-
1 gene in urban environment of Dhaka, Bangladesh.