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20.10.2019 | Review

Collagen and PAPP-A in the Etiology of Postpartum Breast Cancer

verfasst von: Elizabeth Slocum, Doris Germain

Erschienen in: Discover Oncology | Ausgabe 4-6/2019

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Abstract

Pregnancy has a dual effect on the risk of breast cancer. On one hand, pregnancy at a young age is known to be protective. However, pregnancy is also associated with a transient increased risk of breast cancer. For women that have children after the age of 30, the risk remains higher than women who never had children for decades. Involution of the breast has been identified as a window of mammary development associated with the adverse effect of pregnancy. In this review, we summarize the current understanding of the role of involution and describe the role of collagen in this setting. We also discuss the role of a collagen-dependent protease, pappalysin-1, in postpartum breast cancer and its role in activating both insulin-like growth factor signaling and discoidin domain collagen receptor 2, DDR2. Together, these novel advances in our understanding of postpartum breast cancer open the way to targeted therapies against this aggressive breast cancer sub-type.

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Titel: Collagen and PAPP-A in the Etiology of Postpartum Breast Cancer
verfasst von: Elizabeth Slocum
Doris Germain
Publikationsdatum: 20.10.2019
Verlag: Springer US
Erschienen in: Discover Oncology / Ausgabe 4-6/2019
Print ISSN: 1868-8497
Elektronische ISSN: 2730-6011
DOI: https://doi.org/10.1007/s12672-019-00368-z

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Collagen and PAPP-A in the Etiology of Postpartum Breast Cancer

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