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01.12.2012 | Review | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Julie Gutman, S Patrick Kachur, Laurence Slutsker, Alexis Nzila, Theonest Mutabingwa
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-39) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

TK and AN were responsible for the concept of the manuscript. JG was responsible for the acquisition of data, interpretation of the data and writing the manuscript. SPK, LS, AN, and TK contributed to interpretation of the data and critically revised the paper. All authors have seen and approved the final version.

Abstract

The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-level resistance. Probenecid was initially used as an adjunctive therapy to increase the blood concentration of penicillin; it has since been used to augment concentrations of other drugs, including antifolates. The addition of probenecid has been shown to increase the treatment efficacy of SP against malaria, suggesting that the combination of probenecid plus SP may prolong the useful lifespan of SP as an effective agent for IPTp. Here, the literature on the pharmacokinetics, adverse reactions, interactions and available data on the use of these drugs in pregnancy is reviewed, and the possible utility of an SP-probenecid combination is discussed. This article concludes by calling for further research into this potentially useful combination.
Zusatzmaterial
Authors’ original file for figure 1
12936_2011_2002_MOESM1_ESM.pdf
Literatur
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