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07.12.2018 | Original Article

Combined actions of blueberry extract and lithium on neurochemical changes observed in an experimental model of mania: exploiting possible synergistic effects

verfasst von: Luiza Spohr, Mayara Sandrielly Pereira Soares, Pathise Souto Oliveira, Bruna da Silveira de Mattos, Natália Pontes Bona, Nathalia Stark Pedra, Fernanda Cardoso Teixeira, Carlus Augustu Tavares do Couto, Vitor Clasen Chaves, Flávio Henrique Reginatto, Meibel Teixeira Lisboa, Anderson Schwingel Ribeiro, Claiton Leoneti Lencina, Francieli Moro Stefanello, Roselia Maria Spanevello

Erschienen in: Metabolic Brain Disease | Ausgabe 2/2019

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Abstract

Bipolar disorder is a psychiatric disease characterized by recurrent episodes of mania and depression. Blueberries contain bioactive compounds with important pharmacological effects such as neuroprotective and antioxidant actions. The aim of this study was to investigate the effects of blueberry extract and/or lithium on oxidative stress, and acetylcholinesterase (AChE) and Na⁺, K⁺-ATPase activity in an experimental ketamine-induced model of mania. Male Wistar rats were pretreated with vehicle, blueberry extract (200 mg/kg), and/or lithium (45 mg/kg or 22.5 mg/kg twice daily) for 14 days. Between the 8th and 14th days, the animals also received an injection of ketamine (25 mg/kg) or vehicle. On the 15th day the animals received a single injection of ketamine; after 30 min, the locomotor activity was evaluated in an open field test. Ketamine administration induced an increase in locomotor activity. In the cerebral cortex, hippocampus and striatum, ketamine also induced an increase in reactive oxygen species, lipid peroxidation and nitrite levels, as well a decrease in antioxidant enzyme activity. Pretreatment with blueberry extract or lithium was able to prevent this change. Ketamine increased the AChE and Na⁺, K⁺-ATPase activity in brain structures, while the blueberry extract partially prevented these alterations. In addition, our results showed that the neuroprotective effect was not potentiated when lithium and blueberry extract treatment were given together. In conclusion, our findings suggest that blueberry extract has a neuroprotective effect against an experimental model of mania. However, more studies should be performed to evaluate its effects as an adjuvant therapy.

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Titel: Combined actions of blueberry extract and lithium on neurochemical changes observed in an experimental model of mania: exploiting possible synergistic effects
verfasst von: Luiza Spohr
Mayara Sandrielly Pereira Soares
Pathise Souto Oliveira
Bruna da Silveira de Mattos
Natália Pontes Bona
Nathalia Stark Pedra
Fernanda Cardoso Teixeira
Carlus Augustu Tavares do Couto
Vitor Clasen Chaves
Flávio Henrique Reginatto
Meibel Teixeira Lisboa
Anderson Schwingel Ribeiro
Claiton Leoneti Lencina
Francieli Moro Stefanello
Roselia Maria Spanevello
Publikationsdatum: 07.12.2018
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 2/2019
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0353-9

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