nach oben

Journal of Assisted Reproduction and Genetics

Erschienen in:

04.10.2017 | Assisted Reproduction Technologies

Combined advanced parental age has an additive negative effect on live birth rates—data from 4057 first IVF/ICSI cycles

verfasst von: Nicole O. McPherson, Deirdre Zander-Fox, Andrew D. Vincent, Michelle Lane

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The purpose of this study is to determine if there is an additive effect of combined advanced maternal and paternal age on pregnancy and live birth rates.

Methods

Retrospective data analysis of 4057 first cycles at a fertility centre between 2009 and 2013 was compiled. Donor, preimplantation genetic screening and double embryo transfer cycles were excluded. Main outcomes measured were clinical pregnancy, viable pregnancy, live birth and term birth.

Results

Logistic regression indicated strong negative associations for maternal ages exceeding 27 years with clinical pregnancies (p < 0.001), viable pregnancies (p < 0.001), live births (p < 0.001) and term births (p < 0.001). There was evidence of negative associations between paternal age and both viable pregnancies (p = 0.06) and live births (p = 0.04), such that the probability of pregnancy was 10% further reduced for women who were 35 years with a partner over 40 years vs. women aged 35 years with a partner under 30 years. There was evidence of an interaction between maternal age and the paternal age on term births (p = 0.02) such that advanced paternal age’s effect on the probability of a term birth was only evident in couples where the maternal age ranged between ~27 and 35 years.

Conclusions

There is an additive effect to pregnancy and live birth rates when both partners are of an advanced age, thus highlighting the need for pre-conception public health messaging and a combined approach to ART counselling assessing both parental ages in combination.

ABS. Births, Australia, 2010. Canberra: Australian Bureau Of Statistics 2010, Contract No.: 3301.0.

Australian Institute of Health and Welfare. Australias health 2012. Australia's health series no. 13. Cat. no. AUS 156. Canberra: AIHW 2012. p. 628.

Macaldowie A, Wang Y, Chughtai A, Chambers G. Assisted reproductive technology in Australia and New Zealand 2012. Sydney: National Perinatal Epidemiology and Statistics Unit, the University of New South Wales; 2014.

Crawford NM, Steiner AZ. Age-related infertility. Obstet Gynecol Clin N Am. 2015;42(1):15–25. https://doi.org/10.1016/j.ogc.2014.09.005.CrossRef

Duncan FE, Hornick JE, Lampson MA, Schultz RM, Shea LD, Woodruff TK. Chromosome cohesion decreases in human eggs with advanced maternal age. Aging Cell. 2012;11(6):1121–4. https://doi.org/10.1111/j.1474-9726.2012.00866.x.CrossRefPubMedPubMedCentral

Hassold T, Hunt P. Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew. Curr Opin Pediatr. 2009;21(6):703–8. https://doi.org/10.1097/MOP.0b013e328332c6ab.CrossRefPubMedPubMedCentral

Wilding M, Dale B, Marino M, di Matteo L, Alviggi C, Pisaturo ML, et al. Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos. Hum Reprod. 2001;16(5):909–17.CrossRefPubMed

Wright VC, Chang J, Jeng G, Macaluso M. Assisted reproductive technology surveillance—United States, 2005. MMWR Surveill Summ. 2008;57(5):1–23.PubMed

Belloc S, Hazout A, Zini A, Merviel P, Cabry R, Chahine H, et al. How to overcome male infertility after 40: influence of paternal age on fertility. Maturitas. 2014;78(1):22–9. https://doi.org/10.1016/j.maturitas.2014.02.011.CrossRefPubMed

10.

Ford WC, North K, Taylor H, Farrow A, Hull MG, Golding J. Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and hildhood). Hum Reprod. 2000;15(8):1703–8.CrossRefPubMed

11.

Mathieu C, Ecochard R, Bied V, Lornage J, Czyba JC. Cumulative conception rate following intrauterine artificial insemination with husband’s spermatozoa: influence of husband’s age. Hum Reprod. 1995;10(5):1090–7.CrossRefPubMed

12.

Belloc S, Cohen-Bacrie P, Benkhalifa M, Cohen-Bacrie M, De Mouzon J, Hazout A, et al. Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination. Reprod BioMed Online. 2008;17(3):392–7.CrossRefPubMed

13.

Kidd SA, Eskenazi B, Wyrobek AJ. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril. 2001;75(2):237–48.CrossRefPubMed

14.

Klonoff-Cohen HS, Natarajan L. The effect of advancing paternal age on pregnancy and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transfer. Am J Obstet Gynecol. 2004;191(2):507–14. https://doi.org/10.1016/j.ajog.2004.01.035.CrossRefPubMed

15.

de La Rochebrochard E, de Mouzon J, Thepot F, Thonneau P, French National IVFRA. Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France. Fertil Steril. 2006;85(5):1420–4. https://doi.org/10.1016/j.fertnstert.2005.11.040.CrossRef

16.

Thalluri V, Tremellen KP. Ultrasound diagnosed adenomyosis has a negative impact on successful implantation following GnRH antagonist IVF treatment. Hum Reprod. 2012;27(12):3487–92. https://doi.org/10.1093/humrep/des305.CrossRefPubMed

17.

Dorland M, van Kooij RJ, te Velde ER. General ageing and ovarian ageing. Maturitas. 1998;30(2):113–8.CrossRefPubMed

18.

Steuerwald NM, Bermudez MG, Wells D, Munne S, Cohen J. Maternal age-related differential global expression profiles observed in human oocytes. Reprod BioMed Online. 2007;14(6):700–8.CrossRefPubMed

19.

Wilding M, Di Matteo L, Dale B. The maternal age effect: a hypothesis based on oxidative phosphorylation. Zygote. 2005;13(4):317–23. https://doi.org/10.1017/S0967199405003382.CrossRefPubMed

20.

Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA, et al. Age-associated alteration of gene expression patterns in mouse oocytes. Hum Mol Genet. 2004;13(19):2263–78. https://doi.org/10.1093/hmg/ddh241.CrossRefPubMed

21.

Baird DT, Collins J, Egozcue J, Evers LH, Gianaroli L, Leridon H, et al. Fertility and ageing. Hum Reprod Update. 2005;11(3):261–76. https://doi.org/10.1093/humupd/dmi006.CrossRefPubMed

22.

Krieg SA, Henne MB, Westphal LM. Obstetric outcomes in donor oocyte pregnancies compared with advanced maternal age in in vitro fertilization pregnancies. Fertil Steril. 2008;90(1):65–70. https://doi.org/10.1016/j.fertnstert.2007.06.014.CrossRefPubMed

23.

Bartmann AK, Romao GS, Ramos Eda S, Ferriani RA. Why do older women have poor implantation rates? A possible role of the mitochondria. J Assist Reprod Genet. 2004;21(3):79–83.CrossRefPubMedPubMedCentral

24.

Eichenlaub-Ritter U, Vogt E, Yin H, Gosden R. Spindles, mitochondria and redox potential in ageing oocytes. Reprod BioMed Online. 2004;8(1):45–58.CrossRefPubMed

25.

Chang J, Boulet SL, Jeng G, Flowers L, Kissin DM. Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the United States Assisted Reproductive Technology Surveillance Data, 2011-2012. Fertil Steril. 2016;105(2):394–400. https://doi.org/10.1016/j.fertnstert.2015.10.018.CrossRefPubMed

26.

Pacella-Ince L, Zander-Fox DL, Lane M. Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age. Hum Reprod. 2014;29(7):1490–9. https://doi.org/10.1093/humrep/deu071.CrossRefPubMed

27.

Pacella-Ince L, Zander-Fox DL, Lane M. Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age. Reprod Fertil Dev. 2014;26(8):1072–83. https://doi.org/10.1071/RD13178.CrossRefPubMed

28.

Kinare A. Fetal environment. Indian J Radiol Imaging. 2008;18(4):326–44. https://doi.org/10.4103/0971-3026.43848.CrossRefPubMedPubMedCentral

29.

Jenkins TG, Aston KI, Pflueger C, Cairns BR, Carrell DT. Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet. 2014;10(7):e1004458. https://doi.org/10.1371/journal.pgen.1004458.CrossRefPubMedPubMedCentral

30.

Vagnini L, Baruffi RL, Mauri AL, Petersen CG, Massaro FC, Pontes A, et al. The effects of male age on sperm DNA damage in an infertile population. Reprod BioMed Online. 2007;15(5):514–9.CrossRefPubMed

31.

Kumar K, Deka D, Singh A, Mitra DK, Vanitha BR, Dada R. Predictive value of DNA integrity analysis in idiopathic recurrent pregnancy loss following spontaneous conception. J Assist Reprod Genet. 2012; https://doi.org/10.1007/s10815-012-9801-3.

32.

Bakos HW, Thompson JG, Feil D, Lane M. Sperm DNA damage is associated with assisted reproductive technology pregnancy. Int J Androl. 2008;31(5):518–26. https://doi.org/10.1111/j.1365-2605.2007.00803.x.CrossRefPubMed

33.

Gallagher JE, Vine MF, Schramm MM, Lewtas J, George MH, Hulka BS, et al. 32P-postlabeling analysis of DNA adducts in human sperm cells from smokers and nonsmokers. Cancer Epidemiol Biomark Prev. 1993;2(6):581–5.

34.

Brahem S, Mehdi M, Landolsi H, Mougou S, Elghezal H, Saad A. Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss. Urology. 2011;78(4):792–6. https://doi.org/10.1016/j.urology.2011.05.049.CrossRefPubMed

35.

Thomson LK, Zieschang JA, Clark AM. Oxidative deoxyribonucleic acid damage in sperm has a negative impact on clinical pregnancy rate in intrauterine insemination but not intracytoplasmic sperm injection cycles. Fertil Steril. 2011;96(4):843–7. https://doi.org/10.1016/j.fertnstert.2011.07.356.CrossRefPubMed

36.

Simon L, Murphy K, Shamsi MB, Liu L, Emery B, Aston KI, et al. Paternal influence of sperm DNA integrity on early embryonic development. Hum Reprod. 2014;29(11):2402–12. https://doi.org/10.1093/humrep/deu228.CrossRefPubMed

37.

Schmid TE, Eskenazi B, Baumgartner A, Marchetti F, Young S, Weldon R, et al. The effects of male age on sperm DNA damage in healthy non-smokers. Hum Reprod. 2007;22(1):180–7. https://doi.org/10.1093/humrep/del338.CrossRefPubMed

38.

Belloc S, Benkhalifa M, Cohen-Bacrie M, Dalleac A, Amar E, Zini A. Sperm deoxyribonucleic acid damage in normozoospermic men is related to age and sperm progressive motility. Fertil Steril. 2014;101(6):1588–93. https://doi.org/10.1016/j.fertnstert.2014.02.006.CrossRefPubMed

39.

Hammoud SS, Nix DA, Zhang H, Purwar J, Carrell DT, Cairns BR. Distinctive chromatin in human sperm packages genes for embryo development. Nature. 2009;460(7254):473–8. https://doi.org/10.1038/nature08162.CrossRefPubMedPubMedCentral

40.

El Hajj N, Zechner U, Schneider E, Tresch A, Gromoll J, Hahn T, et al. Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males. Sex Dev. 2011;5(2):60–9. https://doi.org/10.1159/000323806.CrossRefPubMed

41.

Jenkins TG, Aston KI, Cairns BR, Carrell DT. Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil Steril. 2013;100(4):945–51. https://doi.org/10.1016/j.fertnstert.2013.05.039.CrossRefPubMed

42.

Milekic MH, Xin Y, O'Donnell A, Kumar KK, Bradley-Moore M, Malaspina D, et al. Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression. Mol Psychiatry. 2014; https://doi.org/10.1038/mp.2014.84.

43.

Reik W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature. 2007;447(7143):425–32. https://doi.org/10.1038/nature05918.CrossRefPubMed

44.

Lord T, Aitken RJ. Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo. Dev Biol. 2015;406(1):1–13. https://doi.org/10.1016/j.ydbio.2015.07.024.CrossRefPubMed

45.

Gawecka JE, Marh J, Ortega M, Yamauchi Y, Ward MA, Ward WS. Mouse zygotes respond to severe sperm DNA damage by delaying paternal DNA replication and embryonic development. PLoS One. 2013;8(2):e56385. https://doi.org/10.1371/journal.pone.0056385.CrossRefPubMedPubMedCentral

46.

Sabban H, Zakhari A, Patenaude V, Tulandi T, Abenhaim HA. Obstetrical and perinatal morbidity and mortality among in-vitro fertilization pregnancies: a population-based study. Arch Gynecol Obstet. 2017;296(1):107–13. https://doi.org/10.1007/s00404-017-4379-8.CrossRefPubMed

47.

Younis JS, Ben-Ami M, Ben-Shlomo I. The Bologna criteria for poor ovarian response: a contemporary critical appraisal. J Ovarian Res. 2015;8:76. https://doi.org/10.1186/s13048-015-0204-9.CrossRefPubMedPubMedCentral

48.

Hojnik N, Vlaisavljevic V, Kovacic B. Morphokinetic characteristics and developmental potential of in vitro cultured embryos from natural cycles in patients with poor ovarian response. Biomed Res Int. 2016;2016:4286528. https://doi.org/10.1155/2016/4286528.CrossRefPubMedPubMedCentral

Titel: Combined advanced parental age has an additive negative effect on live birth rates—data from 4057 first IVF/ICSI cycles
verfasst von: Nicole O. McPherson
Deirdre Zander-Fox
Andrew D. Vincent
Michelle Lane
Publikationsdatum: 04.10.2017
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 2/2018
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-1054-8

Neu im Fachgebiet Gynäkologie und Geburtshilfe

23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Combined advanced parental age has an additive negative effect on live birth rates—data from 4057 first IVF/ICSI cycles

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2018

Key factors enhancing sperm fertilizing ability are transferred from the epididymis to the spermatozoa via epididymosomes in the domestic cat model

Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture

Author Correction: A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols

The normality of sperm in an infertile man with ring chromosome 15: a case report

A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols

FDA-approved drugs that are spermatotoxic in animals and the utility of animal testing for human risk prediction

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie