Skip to main content

30.08.2019 | Original Article | Ausgabe 4/2019

Forensic Science, Medicine and Pathology 4/2019

Combined determination of B-type natriuretic peptide and high-sensitivity troponin I in the postmortem diagnosis of cardiac disease

Forensic Science, Medicine and Pathology > Ausgabe 4/2019
Rafael Bañón, Diana Hernández-Romero, Esperanza Navarro, María Dolores Pérez-Cárceles, José Antonio Noguera-Velasco, Eduardo Osuna
Wichtige Hinweise

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


Cardiac disease is the most common cause of sudden death in Western countries. It is known that high-sensitivity troponin I (hs-cTnI), widely used for detection of myocardial injury, is a sensitive biochemical marker. B-type natriuretic peptide (BNP) is a reliable tool for diagnosing heart failure, and for establishing prognosis or disease severity. We aimed to evaluate the diagnostic efficacy of the postmortem determination of BNP in serum alone or in addition to other biomarkers, such as hs-cTnI and MB isoenzyme of creatine kinase (CK-MB), to ascertain whether its determination improves the post-mortem diagnosis of heart failure-associated causes of death. This study involved 133 cadavers with a mean age of 58.2 (± 17.6) years and a mean postmortem interval of 12.8 (±6.6) h. Cases were assigned into two diagnostic groups, according to the cause of death: cardiac deaths (N = 62) and control (N = 71). In the cardiac group, two categories were established according to morphological features of the heart: ‘ischemic deaths’ (N = 39), and ‘congestive heart’ (n = 23). Both hs-cTnI and BNP were useful in diagnosing cardiac deaths, whereas CK-MB did not have any diagnostic relevance. hs-cTnI is higher in cases which acute ischemia as the principal pathology, while the presence of high BNP values is significantly related with chronic cardiac situations with significant ventricular overload. Our findings show that postmortem determination of hs-cTnI and BNP provides valuable information; hs-cTnI is useful for diagnosis of cardiac deaths, mainly with ischemic implications, and BNP gave better results for the diagnosis of congestive heart failure.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag als Mediziner

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Jetzt e.Med zum Sonderpreis bestellen!

Über diesen Artikel

Weitere Artikel der Ausgabe 4/2019

Forensic Science, Medicine and Pathology 4/2019 Zur Ausgabe

Neu im Fachgebiet Pathologie

01.10.2020 | Magenkarzinom | Schwerpunkt: In-situ-Hybridisierung | Ausgabe 6/2020

ISH-basierte HER2-Diagnostik

30.09.2020 | Schwerpunkt: In-situ-Hybridisierung | Ausgabe 6/2020

RNA-in-situ-Hybridisierung: Technologie, Möglichkeiten und Anwendungsbereiche

28.09.2020 | Lungenkarzinome | Schwerpunkt: In-situ-Hybridisierung | Ausgabe 6/2020

Anwendungen der FISH in der Diagnostik von Lungenkarzinomen