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05.08.2022 | Case Study

Combined-modality treatment for locally advanced cervical cancer in a woman with Bloom-like syndrome: A case report and review of the literature

verfasst von: Syrine Ben Dhia, Hugo Berthou, Mathilde Warcoin, Manuel Rodrigues, Aurélien Noret, Arnaud Beddok, Nina Weber, Dominique Stoppa Lyonnet, Nathaniel Scher

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 1/2023

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Abstract

We report the case of a 46-year-old woman with Bloom-like syndrome affected with locally advanced cervical cancer. She was treated with induction chemotherapy and radical radiation therapy concurrent with chemotherapy (carboplatin and paclitaxel). She was able to complete treatment, but grade III toxicities were observed. The limited relevant literature is presented. We conclude that the management of patients with DNA repair deficiency is challenging for the team in charge because of the potentially high sensitivity to treatment and the lack of clear recommendations in the literature. The main objective remains to deliver the optimal treatment while reducing toxicities.

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Titel: Combined-modality treatment for locally advanced cervical cancer in a woman with Bloom-like syndrome: A case report and review of the literature
verfasst von: Syrine Ben Dhia
Hugo Berthou
Mathilde Warcoin
Manuel Rodrigues
Aurélien Noret
Arnaud Beddok
Nina Weber
Dominique Stoppa Lyonnet
Nathaniel Scher
Publikationsdatum: 05.08.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 1/2023
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-022-01981-8

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Combined-modality treatment for locally advanced cervical cancer in a woman with Bloom-like syndrome: A case report and review of the literature

Abstract

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

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