Erschienen in:
01.12.2007 | Letter
Comment on: Gale EAM (2007) To boldly go—or to go too boldly? The accelerator hypothesis revisited. Diabetologia 50:1571–1575—a reply to the editor
verfasst von:
T. J. Wilkin
Erschienen in:
Diabetologia
|
Ausgabe 12/2007
Einloggen, um Zugang zu erhalten
Excerpt
To the Editor: The Editor’s erudite commentary [
1] on the accelerator hypothesis and its impact on the classification of diabetes [
2] points to where the hypothesis may be vulnerable, offers the opportunity for adjustment and sets an intellectual standard by which the hypothesis will stand or fall. The hypothesis is based on the construct of tempo [
3], and envisages a hierarchy of genotypes that respond to insulin resistance with corresponding rates of beta cell loss. Accordingly, a rise in insulin resistance across a population would predict a leftward shift, resulting in younger age at onset and an increase in incidence, both fundamental tenets of the hypothesis because they spell acceleration. …