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04.02.2017 | LETTER TO THE EDITOR

Comment on “Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis”

verfasst von: Vahid Bagheri, Carolyn L. Geczy

Erschienen in: Inflammation | Ausgabe 5/2017

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Excerpt

Feng and colleagues recently investigated the role of the calcium binding protein, S100A12, in severe acute pancreatitis. They reported that this is induced by caerulein and lipopolysaccharide in mice and anti-recombinant S100A12 antibodies decreased severity [1]. They suggest that “S100A12 is a mediator, not a marker, of acute pancreatitis” and that inhibiting it may represent a novel therapeutic approach. Based on reagents used in this study (antibodies raised against human recombinant S100A12 as immunogen) and strong evidence for the absence of S100A12 in the mouse genome [2, 3], we found that conclusions drawn from this publication are misleading. …

Feng, Z., Z. Yinchu, S. Yinsheng, W. Fengqing, Z. Xiaoyang, L. Jin, and G. Xiaofei. 2015. Potential effects of calcium binding protein S100A12 on severity evaluation and curative effect of severe acute pancreatitis. Inflammation 38(1): 290–297.CrossRefPubMed

Fuellen, G., D. Foell, W. Nacken, C. Sorg, and C. Kerkhoff. 2003. Absence of S100A12 in mouse: implications for RAGE-S100A12 interaction. Trends in Immunology 24(12): 622–623.CrossRefPubMed

Ravasi, T., K. Hsu, J. Goyette, K. Schroder, Z. Yang, F. Rahimi, L.P. Miranda, P.F. Alewood, D.A. Hume, and C. Geczy. 2004. Probing the S100 protein family through genomic and functional analysis. Genomics 84(1): 10–22.CrossRefPubMed

Yan, W.X., C. Armishaw, J. Goyette, Z. Yang, H. Cai, P. Alewood, and C.L. Geczy. 2008. Mast cell and monocyte recruitment by S100A12 and its hinge domain. Journal of Biological Chemistry 283(19): 13035–13043.CrossRefPubMed

Bowman, M.H., J. Wilk, A. Heydemann, G. Kim, J. Rehman, J.A. Lodato, J. Raman, and E.M. McNally. 2010. S100A12 mediates aortic wall remodeling and aortic aneurysm. Circulation Research 106(1): 145–154.CrossRef

Bowman, H., A. Heydemann, J. Gawdzik, R.A. Shilling, and B. Camoretti‐Mercado. 2011. Transgenic expression of human S100A12 induces structural airway abnormalities and limited lung inflammation in a mouse model of allergic inflammation. Clinical & Experimental Allergy 41(6): 878–889.CrossRef

Yan, L., L. Mathew, B. Chellan, B. Gardner, J. Earley, T.S. Puri, and M.A.H. Bowman. 2014. S100/Calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a receptor for advanced glycation end products–dependent manner. Arteriosclerosis, Thrombosis, and Vascular Biology 34(7): 1399–1411.CrossRefPubMedPubMedCentral

Titel: Comment on “Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis”
verfasst von: Vahid Bagheri
Carolyn L. Geczy
Publikationsdatum: 04.02.2017
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 5/2017
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-017-0529-1

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Comment on “Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis”

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