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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Journal of Neurodevelopmental Disorders 1/2014

Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes

Zeitschrift:
Journal of Neurodevelopmental Disorders > Ausgabe 1/2014
Autoren:
Andrea I Quintero, Elliott A Beaton, Danielle J Harvey, Judith L Ross, Tony J Simon
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1866-1955-6-5) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

AIQ performed the statistical analyses, interpreted the data, and drafted the manuscript. TJS conceived of and designed the study, acquired the funding, and generated the experimental task. TJS, EAB, and DJH supported the interpretation of the data and revision of the manuscript. JLR recruited the children with Turner syndrome and oversaw the analyses and testing. All authors read and approved the final manuscript.

Abstract

Background

Chromosome 22q11.2 deletion syndrome (22q11.2DS), fragile X syndrome (FXS), and Turner syndrome (TS) are complex and variable developmental syndromes caused by different genetic abnormalities; yet, they share similar cognitive impairments in the domains of numbers, space, and time. The atypical development of foundational neural networks that underpin the attentional system is thought to result in further impairments in higher-order cognitive functions. The current study investigates whether children with similar higher-order cognitive impairments but different genetic disorders also show similar impairments in alerting, orienting, and executive control of attention.

Methods

Girls with 22q11.2DS, FXS, or TS and typically developing (TD) girls, aged 7 to 15 years, completed an attention network test, a flanker task with alerting and orienting cues. Exploration of reaction times and accuracy allowed us to test for potential commonalities in attentional functioning in alerting, orienting, and executive control. Linear regression models were used to test whether the predictors of group and chronological age were able to predict differences in attention indices.

Results

Girls with 22q11.2DS, FXS, or TS demonstrated unimpaired function of the alerting system and impaired function of the executive control system. Diagnosis-specific impairments were found such that girls with FXS made more errors and had a reduced orienting index, while girls with 22q11.2DS showed specific age-related deficits in the executive control system.

Conclusions

These results suggest that the control but not the implementation of attention is selectively impaired in girls with 22q11.2DS, TS or FXS. Additionally, the age effect on executive control in girls with 22q11.2DS implies a possible altered developmental trajectory.
Zusatzmaterial
Authors’ original file for figure 1
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Authors’ original file for figure 2
11689_2013_99_MOESM2_ESM.pdf
Authors’ original file for figure 3
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