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Journal of Natural Medicines
Erschienen in:

26.10.2022 | Original Paper

Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity

verfasst von: Yuki Yoshino, Naonobu Tanaka, Daisuke Tsuji, Kohji Itoh, Yoshiki Kashiwada

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2023

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Abstract

Three new farnesylated coumarins, communiferulins A–C (1–3), and a farnesylated chromone, ferchromone (4), were isolated from the roots of an Apiaceous plant Ferula communis. Their structures including the relative configurations were elucidated by a combination of spectroscopic analyses and calculations of the NMR data. Communiferulins A–C (1–3) had dihydrofuran rings fused to C-3 and C-4 of their coumarin moieties, while 3 possessed one additional furan ring. HPLC analyses using a chiral column showed 1–4 to be racemates, and the absolute configurations of (+)-1, (–)-1, (+)-2, and (–)-2 were deduced by comparison of their ECD spectra with TDDFT-calculated spectra. Communiferulins A (1) and B (2), and ferchromone (4) showed inhibitory activities on IL-1β production from LPS-stimulated microglial cells.
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Metadaten
Titel
Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity
verfasst von
Yuki Yoshino
Naonobu Tanaka
Daisuke Tsuji
Kohji Itoh
Yoshiki Kashiwada
Publikationsdatum
26.10.2022
Verlag
Springer Nature Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2023
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-022-01657-8

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