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09.12.2015 | Original Article | Ausgabe 5/2016

Tumor Biology 5/2016

Comparative analysis of basaloid and conventional squamous cell carcinomas of the esophagus: prognostic relevance of clinicopathological features and protein expression

Tumor Biology > Ausgabe 5/2016
Yukie Sato-Kuwabara, José Humberto T. G. Fregnani, Juliano Jampietro, Katia Cândido Carvalho, Carolina Parucce Franco, Wilson Luís da Costa Jr., Felipe J. F. Coimbra, Fernando Augusto Soares
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The online version of this article (doi:10.​1007/​s13277-015-4551-3) contains supplementary material, which is available to authorized users.


Basaloid squamous cell carcinoma (BSCC), a variant of squamous cell carcinoma (SCC), is a rare and aggressive epithelial malignancy which has been reported in only 0.1–11 % of primary esophageal carcinomas. In this study, a comparison of clinicopathological features and protein expression between esophageal BSCC (EBSCC) and conventional esophageal SCC (ESCC) cases from Brazil was performed in order to find factors that can be relevant to better characterize EBSCC. The expression of HER2, epidermal growth factor receptor (EGFR), Ki-67, and cyclins (A, B1, and D1) in 111 cases (95 ESCC and 16 EBSCC) was evaluated by immunohistochemistry using tissue microarray. When the clinicopathological data were compared, no significant difference was found between the two histological types. Although the difference is not significant (p = 0.055), the EGFR expression was more frequent in the conventional ESCC than in the EBSCC group. Our results indicate that the clinicopathological profiles of conventional ESCC and EBSCC are similar and provide no indicators for differences in prognosis between these two groups.

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Supplementary Table S1 (DOCX 55 kb)
Supplementary Table S2 (DOCX 58 kb)
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