Comparative analysis of causes and predictors of early death in elderly and young patients with acute promyelocytic leukemia treated with arsenic trioxide
- 04.11.2019
- Original Article – Clinical Oncology
Erschienen in:
- Verfasst von
- Bo Jin
- Yingmei Zhang
- Wenyi Hou
- Fenglin Cao
- Ming Lu
- Huiyuan Yang
- Xuanyu Tian
- Yuan Wang
- Jinxiao Hou
- Jinyue Fu
- Haitao Li
- Jin Zhou
- Erschienen in
- Journal of Cancer Research and Clinical Oncology | Ausgabe 2/2020
Abstract
Purpose
Early death (ED) is the main cause of acute promyelocytic leukemia (APL) treatment failure, and the ED rate is higher for elderly patients than that for young ones. To date, no studies have been found focusing on ED in elderly patients with APL.
Methods
This study retrospectively analyzed the clinical data of 409 consecutive patients with APL (139 patients ≥ 50 years old, 270 patients < 50 years old). All patients received arsenic trioxide alone as induction therapy. The baseline clinical characteristics and ED occurrence and predictors between elderly and young patients with APL were compared and analyzed.
Results
The clinical features of elderly patients at admission were not significantly different from those of young ones. The ED rate of elderly patients was significantly greater than that of young patients (23.74% vs 11.85%, P = 0.0018). Hemorrhage is the main cause of ED in elderly patients, followed by infection and differentiation syndrome. From the 15th to 30th days of treatment, elderly patients had a higher mortality rate than that of young patients (7.83% vs 2.06%, P = 0.009). Male, white blood cell (WBC) count > 10 × 109/L, fibrinogen < 1.0 g/L and low albumin levels were independent risk factors for ED in elderly patients, while ED was only correlated with WBC count, fibrinogen and creatinine levels in young patients.
Conclusion
The results of this study may help design more rational treatment plans for elderly patients with APL based on early mortality risk to reduce the ED rate.
Anzeige
- Titel
- Comparative analysis of causes and predictors of early death in elderly and young patients with acute promyelocytic leukemia treated with arsenic trioxide
- Verfasst von
-
Bo Jin
Yingmei Zhang
Wenyi Hou
Fenglin Cao
Ming Lu
Huiyuan Yang
Xuanyu Tian
Yuan Wang
Jinxiao Hou
Jinyue Fu
Haitao Li
Jin Zhou
- Publikationsdatum
- 04.11.2019
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Journal of Cancer Research and Clinical Oncology / Ausgabe 2/2020
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335 - DOI
- https://doi.org/10.1007/s00432-019-03076-x
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
