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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Ear, Nose and Throat Disorders 1/2015

Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media

BMC Ear, Nose and Throat Disorders > Ausgabe 1/2015
Katsuhisa Ikeda, Shigeki Misawa, Takeshi Kusunoki
Wichtige Hinweise

Competing interests

The authors have no funding, financial relationships or conflict of interest to disclose.
This material has never been published and is not currently under evaluation in any other peer-reviewed publication.

Authors’ contributions

KI and TK were involved in all stages of the study. NM was involved in measurement of MIC. All authors gave final approval for the publication of this manuscript. All authors read and approved the final manuscript.



The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM).


We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa (50 strains).


STFX exhibited the most potent activity of both MIC50 and MIC90, followed by CPFX, LVFX, and GRNX. The number of GRNX-resistant strains was significantly greater than those of LVFX, CPFX, and STFX (P < 0.05).


STFX showed the most potent activity against P. aeruginosa for recent pathogens recovered from CSOM as compared with the others, suggesting that the clinical application of topical STFX would be useful to prevent the emergence of resistant mutants of P. aeruginosa.
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