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Nuclear Medicine and Molecular Imaging
Erschienen in: Nuclear Medicine and Molecular Imaging 1/2019

12.12.2018 | Original Article

Comparative Cardiac Phantom Study Using Tc-99m/I-123 and Tl-201/I-123 Tracers with Cadmium-Zinc-Telluride Detector-Based Single-Photon Emission Computed Tomography

verfasst von: Takanaga Niimi, Mamoru Nanasato, Mitsuo Sugimoto, Hisatoshi Maeda

Erschienen in: Nuclear Medicine and Molecular Imaging | Ausgabe 1/2019

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Abstract

Objective

A recently introduced single-photon emission computed tomography (SPECT), based on cadmium-zinc-telluride (CZT) detectors (D-SPECT), supports high energy resolution for cardiac imaging. Importantly, the high energy resolution may allow simultaneous dual-isotope (SDI) imaging (e.g., using Tc-99m and I-123). We quantitatively evaluated Tc-99m/I-123 SDI imaging by D-SPECT in comparison with conventional T1-201/I-123.

Materials and Methods

Energy resolution was measured as a percentage of the full width at half maximum (FWHM) for Tc-99m, I-123, and Tl-201. The impact of cross-talk and reconstructed image contrast were quantified by measuring the contrast-to-noise ratio (CNR), and the transmural defect contrast in the left ventricle wall (CTD) induced by a difference in energy, for combinations of Tc-99m/I-123 or Tl-201/I-123, using an RH-2 cardiac phantom. Corresponding measurement was also carried out in Anger SPECT (A-SPECT).

Results

The energy resolution of the D-SPECT system was 5.4%/5.1% for Tc-99m/I-123 and 5.4%/5.3% for Tl-201/I-123, which was approximately two times higher than the A-SPECT. No notable difference was confirmed in the CNRs of the two systems, but T1-201/I-123 showed overall higher value than Tc-99m/I-123. Compared to A-SPECT, CTD of D-SPECT significantly increased with both Tc-99m/I-123 and T1-201/I-123 (p < 0.05). In DSPECT, the combination of Tc-99m/I-123 had a slightly better CTD than T1-201/I-123. In addition, CTD of Tc-99m/I-123 was improved with scatter correction at both nuclides (p < 0.05), but in Tl-201/I-123, no significant improvement was confirmed in I-123 (p > 0.05).

Conclusion

D-SPECT was considered to be capable of performing high-quality SDI imaging using Tc-99m/I-123.
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Metadaten
Titel
Comparative Cardiac Phantom Study Using Tc-99m/I-123 and Tl-201/I-123 Tracers with Cadmium-Zinc-Telluride Detector-Based Single-Photon Emission Computed Tomography
verfasst von
Takanaga Niimi
Mamoru Nanasato
Mitsuo Sugimoto
Hisatoshi Maeda
Publikationsdatum
12.12.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Nuclear Medicine and Molecular Imaging / Ausgabe 1/2019
Print ISSN: 1869-3474
Elektronische ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-018-0559-0

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