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24.07.2020 | Concise Research Report

Comparative Efficacy and Safety of Intravenous Verapamil and Diltiazem for Rate Control in Rapidly Conducted Atrial Fibrillation and Atrial Flutter

verfasst von: Furqan A. Rajput, MD, MS, Lianlian Du, MS, Richard J. Chappell, PhD, Theodore J. Berei, PharmD, Zachary D. Goldberger, MD, MS, Jennifer M. Wright, MD

Erschienen in: Journal of General Internal Medicine | Ausgabe 12/2020

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Excerpt

Beta-blockers and non-dihydropyridine calcium channel blockers (CCBs) are first-line therapy for heart rate (HR) control in atrial fibrillation (AF) and atrial flutter (AFL) .¹ While diltiazem is used more frequently during inpatient practice than verapamil,² a nationwide shortage of intravenous (IV) diltiazem starting in February 2018³ led to the more frequent use of alternative agents for rate control, including IV verapamil. …

January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, Jr., et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol 2014;64(21):e1-76. doi:https://doi.org/10.1016/j.jacc.2014.03.022CrossRefPubMed

Rogenstein C, Kelly AM, Mason S, Schneider S, Lang E, Clement CM, et al. An international view of how recent-onset atrial fibrillation is treated in the emergency department. Acad Emerg Med. 2012;19(11):1255-60. doi:https://doi.org/10.1111/acem.12016CrossRefPubMed

U.S. Food and Drug Administration. Current and resolved drug shortages and discontinuations reported to fda. 2019, May 08. https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Diltiazem Hydrochloride&st=c&tab=tabs-1.

Fromm C, Suau SJ, Cohen V, Likourezos A, Jellinek-Cohen S, Rose J, et al. Diltiazem vs. Metoprolol in the Management of Atrial Fibrillation or Flutter with Rapid Ventricular Rate in the Emergency Department. J Emerg Med. 2015;49(2):175-82. doi:https://doi.org/10.1016/j.jemermed.2015.01.014CrossRefPubMed

Salerno DM, Dias VC, Kleiger RE, Tschida VH, Sung RJ, Sami M, et al. Efficacy and safety of intravenous diltiazem for treatment of atrial fibrillation and atrial flutter. The Diltiazem-Atrial Fibrillation/Flutter Study Group. Am J Cardiol. 1989;63(15):1046-51. doi:https://doi.org/10.1016/0002-9149(89)90076-3CrossRefPubMed

Phillips BG, Gandhi AJ, Sanoski CA, Just VL, Bauman JL. Comparison of intravenous diltiazem and verapamil for the acute treatment of atrial fibrillation and atrial flutter. Pharmacotherapy. 1997;17(6):1238-45.PubMed

Titel: Comparative Efficacy and Safety of Intravenous Verapamil and Diltiazem for Rate Control in Rapidly Conducted Atrial Fibrillation and Atrial Flutter
verfasst von: Furqan A. Rajput, MD, MS
Lianlian Du, MS
Richard J. Chappell, PhD
Theodore J. Berei, PharmD
Zachary D. Goldberger, MD, MS
Jennifer M. Wright, MD
Publikationsdatum: 24.07.2020
Verlag: Springer International Publishing
Erschienen in: Journal of General Internal Medicine / Ausgabe 12/2020
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI: https://doi.org/10.1007/s11606-020-06051-2

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Comparative Efficacy and Safety of Intravenous Verapamil and Diltiazem for Rate Control in Rapidly Conducted Atrial Fibrillation and Atrial Flutter

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