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01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Complementary and Alternative Medicine 1/2018

Comparative efficacy of Chinese herbal injections for treating chronic heart failure: a network meta-analysis

BMC Complementary and Alternative Medicine > Ausgabe 1/2018
Kai-Huan Wang, Jia-Rui Wu, Dan Zhang, Xiao-Jiao Duan, Meng-Wei Ni
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12906-018-2090-3) contains supplementary material, which is available to authorized users.



On account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injection, Shenfu injection, Shengmai injection, Shenmai injection, Shenqi Fuzheng injection, Yiqifumai injection) on the basis of western medicine (WM) treatment in CHF.


Literature search was conducted in Embase, the Cochrane Library, Pubmed, Chinese Biological Medicine Database, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database from inception to June 12nd 2017, and study selection was abided by a prior eligible criteria.


Ultimately, a total of 113 randomized controlled trials (RCTs) were enrolled. The clinical data of the effective clinical rate, left ventricular ejection fraction, cardiac output and others outcomes was estimated by Stata software and Winbugs software. Risk of bias was assessed by Cochrane Collaboration’s tools. Integrating the each outcome’s results, a combination of Shengmai injection/Shenmai injection and WM obtain a first rank in most outcomes, particularly primary outcomes.


In conclusion, on the basis of WM, Shengmai injection or Shenmai injection may be a perforable treatment in CHF. In terms of insufficient of this study, more high quality RCTs needed to implement to support our conclusions.
Additional file 1: PRISMA checklist for network meta-analysis. This file contained items about PRISMA checklist for network meta-analysis and corresponding pages of this study. (DOC 66 kb)
Additional file 2: Search strategy. This file contained the search strategy of traditional Chinese medicine injections and English database. (DOC 39 kb)
Additional file 3: Characteristics of included randomized controlled trials. This file contained the information about included randomized controlled trials. (DOC 38 kb)
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