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Erschienen in: Aesthetic Plastic Surgery 4/2019

15.04.2019 | Original Article

Comparative Evaluation of the Biodegradability and Wrinkle Reduction Efficacy of Human-Derived Collagen Filler and Hyaluronic Acid Filler

verfasst von: Jong Hwan Kim, Tae-Rin Kwon, Sung Woo Hong, Joon Seok, Jae Min Kim, Ji Yeon Hong, Sung Eun Lee, Sung Won Han, Beom Joon Kim

Erschienen in: Aesthetic Plastic Surgery | Ausgabe 4/2019

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Abstract

Background

The development of fillers for wrinkle prevention is growing to meet rising demands to reduce the aging of skin.

Objective

In this experiment, we confirmed the effects of human collagen and hyaluronic acid filler biodegradation for wrinkle reduction using a photo-aging mouse model.

Materials and Methods

A total of 10 hairless mice (SKH1-Hrhr) were randomly divided into two groups and injected with hyaluronic acid and human-derived collagen filler. At 0, 2, 4, 8, and 12 weeks, PRIMOSlite®, folliscope, and MRI were used to evaluate the biodegradability of the fillers after the injections. We also studied the photo-aging mouse model for skin roughness and histological evaluation and confirmed that the filler injection had excellent anti-wrinkle effects.

Results

Human-derived collagen fillers had excellent biodegradability compared to that of hyaluronic acid fillers. The skin surface roughness in the photo-aging mouse models was significantly reduced after injections of human-derived collagen filler.

Conclusion

Our results showed that the human-derived collagen filler had excellent biodegradability and effectively reduced wrinkle formation in a photo-aging mouse model.

No Level Assigned

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
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Metadaten
Titel
Comparative Evaluation of the Biodegradability and Wrinkle Reduction Efficacy of Human-Derived Collagen Filler and Hyaluronic Acid Filler
verfasst von
Jong Hwan Kim
Tae-Rin Kwon
Sung Woo Hong
Joon Seok
Jae Min Kim
Ji Yeon Hong
Sung Eun Lee
Sung Won Han
Beom Joon Kim
Publikationsdatum
15.04.2019
Verlag
Springer US
Erschienen in
Aesthetic Plastic Surgery / Ausgabe 4/2019
Print ISSN: 0364-216X
Elektronische ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-019-01373-x

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