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01.11.2019 | Occupational Allergies (JA Poole, Section Editor) | Ausgabe 11/2019

Current Allergy and Asthma Reports 11/2019

Comparative Review of Asthma in Farmers and Horses

Zeitschrift:
Current Allergy and Asthma Reports > Ausgabe 11/2019
Autoren:
M. Katie Sheats, Kaori U. Davis, Jill A. Poole
Wichtige Hinweise
Topical Collection on Occupational Allergies

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Purpose of Review

Farmers are routinely exposed to organic dusts and aeroallergens that can have adverse respiratory health effects including asthma. Horses are farm-reared large animals with similar exposures and can develop equine asthma syndrome (EAS). This review aims to compare the etiology, pathophysiology, and immunology of asthma in horses compared to farmers and highlights the horse as a potential translational animal model for organic dust-induced asthma in humans.

Recent Findings

Severe EAS shares many clinical and pathological features with various phenotypes of human asthma including allergic, non-allergic, late onset, and severe asthma. EAS disease features include variable airflow obstruction, cough, airway hyperresponsiveness, airway inflammation/remodeling, neutrophilic infiltrates, excess mucus production, and chronic innate immune activation.

Summary

Severe EAS is a naturally occurring and biologically relevant, translational animal disease model that could contribute to a more thorough understanding of the environmental and immunologic factors contributing to organic dust-induced asthma in humans.

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