Comparative Risk of Gallstone Formation After Sleeve Gastrectomy and Roux-En-Y Gastric Bypass: A Systematic Review and Meta-Analysis
- 18.11.2025
- Review
Erschienen in:
- Verfasst von
- Wilson Silva-Chavez
- Alexander Bustamante-Cabrejo
- Jose Caballero-Alvarado
- Victor Lau-Torres
- Joaquin Sarmiento-Falen
- Carlos Zavaleta-Corvera
- Erschienen in
- Obesity Surgery | Ausgabe 12/2025
Abstract
Objective
To compare the risk of gallstone formation after sleeve gastrectomy (SG) versus Roux-en-Y gastric bypass (RYGB).
Methods
We searched PubMed, Scopus, Web of Science, and Embase following PRISMA 2020. Eligible observational studies reported incident cholelithiasis after SG or RYGB. Risk of bias was assessed with the Newcastle–Ottawa Scale (NOS). Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using random-effects (DerSimonian–Laird). Prespecified subgroup analyses considered follow-up duration (< 2 vs. ≥ 2 years).
Results
Ten studies (n = 195,665) met inclusion criteria. Overall, SG was associated with a lower risk of gallstone formation than RYGB (OR 0.68, 95% CI 0.53–0.88; p = 0.003; I²=75%). The protective association was evident in studies with < 2 years of follow-up (OR 0.59, 95% CI 0.42–0.82; I²=46%) but not in ≥ 2-year follow-up (OR 0.84, 95% CI 0.55–1.28; I²=70%). In influence analysis excluding the largest database study, the summary effect became statistically non-significant with extreme heterogeneity (OR 0.31, 95% CI 0.03–2.72; I²=99%). Methodological quality was moderate to high (NOS 6–8/9).
Conclusions
SG is associated with a lower short-term risk of gallstone formation compared with RYGB, although results are heterogeneous and sensitive to study weight. Standardized outcome definitions, longer follow-up, and stratification by UDCA use are needed to refine comparative risk estimates.
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- Titel
- Comparative Risk of Gallstone Formation After Sleeve Gastrectomy and Roux-En-Y Gastric Bypass: A Systematic Review and Meta-Analysis
- Verfasst von
-
Wilson Silva-Chavez
Alexander Bustamante-Cabrejo
Jose Caballero-Alvarado
Victor Lau-Torres
Joaquin Sarmiento-Falen
Carlos Zavaleta-Corvera
- Publikationsdatum
- 18.11.2025
- Verlag
- Springer US
- Erschienen in
-
Obesity Surgery / Ausgabe 12/2025
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428 - DOI
- https://doi.org/10.1007/s11695-025-08388-1
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