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01.12.2014 | Short report | Ausgabe 1/2014 Open Access

AIDS Research and Therapy 1/2014

Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection

AIDS Research and Therapy > Ausgabe 1/2014
Yanmei Jiao, Xin Sun, Xiaojie Huang, Wei Li, Tong Zhang, Hao Wu
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1742-6405-11-22) contains supplementary material, which is available to authorized users.
Yanmei Jiao, Xin Sun contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

YJ drafted the manuscript and statistical analyses. XS participated in flow cytometric analysis. TZ followed up patients and collected samples. XS and XH assisted with manuscript and data anlysis. YJ and WL assisted with flow cytometric analysis and data acquisition. HW conceived the study and participated in the data analysis. HW supervised and coordinated the study. All authors have read and approved the final manuscript.


The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl within 2 years of HIV-1 infection (CD4 Low Group), while the other group maintained CD4 counts above 500 cells/μl (CD4 High Group). We did not find statistical difference in the pDC number between the two groups during acute HIV-1 infection. However, the mDC number was significantly lower in the CD4 Low Group than in the CD4 High Group.
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