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International Urology and Nephrology

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28.11.2016 | Urology - Original Paper

Comparing the bulking effect of calcium hydroxyapatite and Deflux injection into the bladder neck for improvement of urinary incontinence in bladder exstrophy–epispadias complex

verfasst von: Sahar Eftekharzadeh, Nastaran Sabetkish, Shabnam Sabetkish, Abdol-Mohammad Kajbafzadeh

Erschienen in: International Urology and Nephrology | Ausgabe 2/2017

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Abstract

Objectives

The aim of this study was to evaluate the efficacy of the endoscopic injection of calcium hydroxyapatite (CaHA) into the bladder neck (BN) region of patients with urinary incontinence and bladder exstrophy–epispadias complex (BEEC).

Patients and methods

We designed a retrospective cohort study in which we retrospectively studied medical charts of female and male patients of BEEC who had undergone CaHA or Deflux injection for continence improvement between 2009 and 2014. Sixteen incontinent patients with a mean ± SD age of 8.09 ± 3.5 years received an endoscopic submucosal injection of 5.4 ml of pure CaHA powder with autologous plasma (group A). Patients in group B (N = 21), control group, with a mean ± SD age of 7.51 ± 2.8 years received Deflux injection (5.1 ml). The mean follow-up after injection was 38 ± 5.2 and 33 ± 4.1 months in groups A and B, respectively.

Results

No post-injection complication was detected in none of the patients during the follow-up. Eleven patients (68.75%) in group A became socially dry following 1–2 injections, the degree of incontinence was improved in 4 patients (25%), and there was no change in one patient (6.25%). However, Deflux injection resulted in complete dryness in 14 (66.66%), improvement in the degree of incontinence in 5 (23.81%) and no change in 2 patients (9.52%), leading to no significant difference in continence achievement between CaHA and Deflux groups (p = 0.9). The statistical analysis was not significantly different in terms of bladder capacity (p = 0.7) or Q max (p = 0.8).

Conclusion

The preliminary results of this study revealed that CaHA may be applied as an affordable bulking agent in treatment of urinary incontinence in BEEC.

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Titel: Comparing the bulking effect of calcium hydroxyapatite and Deflux injection into the bladder neck for improvement of urinary incontinence in bladder exstrophy–epispadias complex
verfasst von: Sahar Eftekharzadeh
Nastaran Sabetkish
Shabnam Sabetkish
Abdol-Mohammad Kajbafzadeh
Publikationsdatum: 28.11.2016
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 2/2017
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-016-1464-z

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Comparing the bulking effect of calcium hydroxyapatite and Deflux injection into the bladder neck for improvement of urinary incontinence in bladder exstrophy–epispadias complex

Abstract

Objectives

Patients and methods

Results

Conclusion

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Patients and methods

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Conclusion

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