Background
Methods
Data collection and processing
Data analysis
Results
HCAI care only | Some HCAI care | Other London women | ||||
---|---|---|---|---|---|---|
N
| % |
N
| % |
N
| % | |
Number of cases | 199 | 278 | 31,234 | |||
Mean age (years) | 53 | 54 | 61 | |||
Age group | ||||||
<50 | 98 | 49.2 | 131 | 47.1 | 7,792 | 24.9 |
50-59 | 33 | 16.6 | 56 | 20.1 | 7,243 | 23.2 |
60-69 | 43 | 21.6 | 58 | 20.9 | 7,210 | 23.1 |
70-79 | 17 | 8.5 | 18 | 6.5 | 4,783 | 15.3 |
80+ | 8 | 4.0 | 15 | 5.4 | 4,206 | 13.5 |
Socioeconomic deprivation quintile | ||||||
1 = Affluent | 62 | 31.2 | 97 | 34.9 | 4,182 | 13.4 |
2 | 33 | 16.6 | 51 | 18.3 | 4,437 | 14.2 |
3 | 45 | 22.6 | 54 | 19.4 | 5,928 | 19.0 |
4 | 33 | 16.6 | 46 | 16.5 | 7,932 | 25.4 |
5 = Deprived | 26 | 13.1 | 30 | 10.8 | 8,755 | 28.0 |
Year of diagnosis | ||||||
2005 | 17 | 8.5 | 22 | 7.9 | 4,286 | 13.7 |
2006 | 19 | 9.5 | 32 | 11.5 | 4,153 | 13.3 |
2007 | 51 | 25.6 | 37 | 13.3 | 4,366 | 14.0 |
2008 | 30 | 15.1 | 38 | 13.7 | 4,400 | 14.1 |
2009 | 29 | 14.6 | 57 | 20.5 | 4,649 | 14.9 |
2010 | 42 | 21.1 | 59 | 21.2 | 4,723 | 15.1 |
2011 | 11 | 5.5 | 33 | 11.9 | 4,657 | 14.9 |
Stage of disease | ||||||
1 | 64 | 32.2 | 109 | 39.2 | 9,836 | 31.5 |
2 | 42 | 21.1 | 95 | 34.2 | 10,311 | 33.0 |
3 | 1 | 0.5 | 28 | 10.1 | 2,979 | 9.5 |
4 | 2 | 1.0 | 6 | 2.2 | 2,639 | 8.4 |
Not known | 90 | 45.2 | 40 | 14.4 | 5,469 | 17.5 |
Screening category | ||||||
Not Screen-detected | 194 | 97.5 | 262 | 94.2 | 23,430 | 75.0 |
Screen-detected | 5 | 2.5 | 16 | 5.8 | 7,804 | 25.0 |
Treatment | ||||||
Any cancer surgery | 137 | 68.8 | 241 | 86.7 | 20,747 | 66.4 |
Any chemotherapy | 61 | 30.7 | 140 | 50.4 | 9,841 | 31.5 |
Any radiotherapy | 78 | 39.2 | 140 | 50.4 | 8,197 | 26.2 |
Any hormone therapy | 40 | 20.1 | 121 | 43.5 | 8,964 | 28.7 |
Unadjusted | Adjusted for age | Adjusted for age and deprivation | Adjusted for age, deprivation, and year of diagnosis | Adjusted for age, deprivation, year of diagnosis, and stage | Adjusted for age, deprivation, year of diagnosis, stage, and treatment | |
---|---|---|---|---|---|---|
HR (95 % CI) | HR (95 % CI) | HR (95 % CI) | HR (95 % CI) | HR (95 % CI) | HR (95 % CI) | |
Other London women | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
HCAI care only | 0.48 (0.32, 0.74) | 0.66 (0.43, 1.02) | 0.70 (0.46, 1.08) | 0.70 (0.45, 1.07) | 0.72 (0.47, 1.10) | 0.79 (0.51, 1.21) |
Some HCAI care | 0.24 (0.14, 0.41) | 0.32 (0.19, 0.54) | 0.34 (0.20, 0.58) | 0.35 (0.21, 0.59) | 0.40 (0.24, 0.67) | 0.48 (0.28, 0.80) |
χ
2-test (2 d.f.) | 39.35 | 21.69 | 18.40 | 18.30 | 14.03 | 8.83 |
p-heterogeneity | <0.0001 | <0.0001 | <0.0001 | 0.0001 | 0.0009 | 0.0121 |
Age group | ||||||
<40 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
40-44 | 0.85 (0.72, 1.01) | 0.86 (0.73, 1.02) | 0.86 (0.73, 1.02) | 0.88 (0.74, 1.03) | 0.96 (0.81, 1.13) | |
45-49 | 0.77 (0.65, 0.89) | 0.78 (0.67, 0.91) | 0.78 (0.67, 0.92) | 0.81 (0.70, 0.95) | 0.89 (0.76, 1.04) | |
50-54 | 0.65 (0.56, 0.77) | 0.67 (0.57, 0.78) | 0.67 (0.57, 0.78) | 0.78 (0.66, 0.91) | 0.86 (0.74, 1.01) | |
55-59 | 0.83 (0.72, 0.97) | 0.86 (0.74, 1.00) | 0.85 (0.74, 0.99) | 0.97 (0.84, 1.13) | 1.11 (0.95, 1.29) | |
60-64 | 0.85 (0.73, 0.99) | 0.88 (0.76, 1.02) | 0.88 (0.76, 1.02) | 1.06 (0.91, 1.23) | 1.27 (1.10, 1.48) | |
65-69 | 1.05 (0.91, 1.21) | 1.08 (0.93, 1.25) | 1.08 (0.93, 1.24) | 1.30 (1.12, 1.50) | 1.65 (1.42, 1.91) | |
70-74 | 2.01 (1.74, 2.30) | 2.07 (1.80, 2.39) | 2.07 (1.80, 2.38) | 2.24 (1.95, 2.58) | 2.83 (2.45, 3.27) | |
75-79 | 2.85 (2.49, 3.26) | 2.94 (2.57, 3.36) | 2.94 (2.57, 3.36) | 3.08 (2.69, 3.53) | 3.91 (3.40, 4.50) | |
80+ | 6.19 (5.48, 6.99) | 6.41 (5.67, 7.24) | 6.42 (5.69, 7.26) | 6.10 (5.40, 6.89) | 6.87 (6.03, 7.82) | |
χ
2-test (1 d.f.) | 2,755.90 | 2,804.15 | 2,804.01 | 2,540.64 | 2,052.19 | |
p-trend | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | |
Socioeconomic deprivation quintile | ||||||
1 = Affluent | 1.00 | 1.00 | 1.00 | 1.00 | ||
2 | 0.97 (0.88, 1.07) | 0.96 (0.87, 1.06) | 0.97 (0.87, 1.07) | 0.97 (0.87, 1.07) | ||
3 | 1.06 (0.96, 1.16) | 1.05 (0.96, 1.15) | 1.04 (0.95, 1.15) | 1.04 (0.95, 1.14) | ||
4 | 1.18 (1.08, 1.29) | 1.18 (1.08, 1.29) | 1.19 (1.09, 1.30) | 1.16 (1.07, 1.27) | ||
5 = Deprived | 1.37 (1.26, 1.49) | 1.36 (1.25, 1.48) | 1.27 (1.17, 1.38) | 1.22 (1.12, 1.33) | ||
χ
2-test (1 d.f.) | 92.81 | 92.14 | 61.05 | 44.50 | ||
p-trend | <0.0001 | <0.0001 | <0.0001 | <0.0001 | ||
Year of diagnosis | ||||||
2005 | 1.00 | 1.00 | 1.00 | |||
2006 | 0.99 (0.91, 1.07) | 1.08 (0.99, 1.17) | 1.08 (1.00, 1.17) | |||
2007 | 1.00 (0.92, 1.09) | 1.10 (1.02, 1.20) | 1.07 (0.98, 1.16) | |||
2008 | 0.98 (0.89, 1.06) | 1.11 (1.01, 1.21) | 1.02 (0.93, 1.11) | |||
2009 | 0.87 (0.79, 0.96) | 0.93 (0.85, 1.03) | 0.87 (0.80, 0.96) | |||
2010 | 0.81 (0.73, 0.90) | 0.82 (0.74, 0.91) | 0.84 (0.76, 0.93) | |||
2011 | 0.74 (0.65, 0.84) | 0.81 (0.72, 0.92) | 0.83 (0.73, 0.94) | |||
χ
2-test (1 d.f.) | 33.22 | 22.52 | 27.02 | |||
p-trend | <0.0001 | <0.0001 | <0.0001 | |||
Stage of disease | ||||||
1 | 1.00 | 1.00 | ||||
2 | 1.02 (0.94, 1.11) | 1.10 (1.01, 1.19) | ||||
3 | 2.28 (2.07, 2.51) | 2.27 (2.06, 2.51) | ||||
4 | 6.37 (5.89, 6.90) | 4.90 (4.52, 5.31) | ||||
Not known | 2.67 (2.47, 2.88) | 1.82 (1.68, 1.96) | ||||
χ
2-test (1 d.f.) | 2,924.02 | 1,630.20 | ||||
Excl. NK p-trend | <0.0001 | <0.0001 | ||||
Radiotherapy | ||||||
No | 1.00 | |||||
Yes | 0.82 (0.77, 0.89) | |||||
χ
2-test (1 d.f.) | 28.19 | |||||
p-heterogeneity | <0.0001 | |||||
Chemotherapy | ||||||
No | 1.00 | |||||
Yes | 1.29 (1.20, 1.38) | |||||
χ
2-test (1 d.f.) | 50.87 | |||||
p-heterogeneity | <0.0001 | |||||
Cancer surgery | ||||||
No | 1.00 | |||||
Yes | 0.40 (0.37, 0.42) | |||||
χ
2-test (1 d.f.) | 962.80 | |||||
p-heterogeneity | <0.0001 | |||||
Hormone therapy | ||||||
No | 1.00 | |||||
Yes | 0.80 (0.75, 0.85) | |||||
χ
2-test (1 d.f.) | 58.07 | |||||
p-heterogeneity | <0.0001 |