Skip to main content
Erschienen in: Annals of Surgical Oncology 4/2010

01.04.2010 | Hepatobiliary Tumors

Comparing the Clinical and Economic Impact of Laparoscopic Versus Open Liver Resection

verfasst von: Tsafrir Vanounou, MD, MBA, Jennifer L. Steel, PhD, Kevin Tri Nguyen, MD, PhD, Allan Tsung, MD, J. Wallis Marsh, MD, MBA, David A. Geller, MD, T. Clark Gamblin, MD, MS

Erschienen in: Annals of Surgical Oncology | Ausgabe 4/2010

Einloggen, um Zugang zu erhalten

Abstract

Background

Laparoscopic liver resection has thus far not gained widespread acceptance among liver surgeons. Valid questions remain regarding the relative clinical superiority of the laparoscopic approach as well as whether laparoscopic hepatectomy carries any economic benefit compared with open liver surgery.

Objective

The aim of this work is to compare the clinical and economic impact of laparoscopic versus open left lateral sectionectomy (LLS).

Methods

Between May 2002 and July 2008, 44 laparoscopic LLS and 29 open LLS were included in the analysis. Deviation-based cost modeling (DBCM) was utilized to compare the combined clinical and economic impact of the open and laparoscopic approaches.

Results

The laparoscopic approach compared favorably with the open approach from both a clinical and economic standpoint. Not only was the median length of stay (LOS) shorter by 2 days in the laparoscopic group (3 versus 5 days, respectively, P = 0.001), but the laparoscopic cohort also benefited from a significant reduction in postoperative morbidity (P = 0.001). Because the groups differed significantly in age and ratio of benign to malignant disease, a subgroup analysis limited to patients with malignant disease was undertaken. The same reduction in LOS and postoperative morbidity was evident within the malignant subgroup undergoing laparoscopic LLS (P = 0.003). The economic impact of the laparoscopic approach was noteworthy, with the laparoscopic approach US$1,527–2,939 more cost efficient per patient compared with the open technique.

Conclusion

Our study seems not only to corroborate the safety and clinical benefit of the laparoscopic approach but also suggests a fiscally important cost advantage for the minimally invasive approach.
Literatur
1.
Zurück zum Zitat Nguyen KT, Gamblin TC, Geller DA. World review of laparoscopic liver resection—3,804 patients. Ann Surg. 2009;250(5):831–41.CrossRefPubMed Nguyen KT, Gamblin TC, Geller DA. World review of laparoscopic liver resection—3,804 patients. Ann Surg. 2009;250(5):831–41.CrossRefPubMed
2.
Zurück zum Zitat Nguyen KT, Gamblin TC, Geller DA. Laparoscopic liver resection for cancer. Future Oncol. 2008;4(5):661–70.CrossRefPubMed Nguyen KT, Gamblin TC, Geller DA. Laparoscopic liver resection for cancer. Future Oncol. 2008;4(5):661–70.CrossRefPubMed
3.
Zurück zum Zitat Nguyen KT, Laurent A, Dagher I, Geller DA, Steel J, Thomas MT, et al. Minimally invasive liver resection for metastatic colorectal cancer: a multi-institutional, international report of safety, feasibility and early outcomes. Ann Surg. 2009;250(5):842–8.CrossRefPubMed Nguyen KT, Laurent A, Dagher I, Geller DA, Steel J, Thomas MT, et al. Minimally invasive liver resection for metastatic colorectal cancer: a multi-institutional, international report of safety, feasibility and early outcomes. Ann Surg. 2009;250(5):842–8.CrossRefPubMed
5.
Zurück zum Zitat Buell JF, Thomas MT, Rudich S, et al. Experience with more than 500 minimally invasive hepatic procedures. Ann Surg. 2008;248(3):475–86.PubMed Buell JF, Thomas MT, Rudich S, et al. Experience with more than 500 minimally invasive hepatic procedures. Ann Surg. 2008;248(3):475–86.PubMed
6.
Zurück zum Zitat Dagher I, Proske JM, Carloni A, et al. Laparoscopic liver resection: results for 70 patients. Surg Endosc. 2007;21(4):619–24.CrossRefPubMed Dagher I, Proske JM, Carloni A, et al. Laparoscopic liver resection: results for 70 patients. Surg Endosc. 2007;21(4):619–24.CrossRefPubMed
7.
Zurück zum Zitat Ardito F, Tayar C, Laurent A, Karoui M, Loriau J, Cherqui D. Laparoscopic liver resection for benign disease. Arch Surg. 2007;142(12):1188–93; discussion 1193. Ardito F, Tayar C, Laurent A, Karoui M, Loriau J, Cherqui D. Laparoscopic liver resection for benign disease. Arch Surg. 2007;142(12):1188–93; discussion 1193.
8.
Zurück zum Zitat O’Rourke N, Fielding G. Laparoscopic right hepatectomy: surgical technique. J Gastrointest Surg. 2004;8(2):213–6.CrossRefPubMed O’Rourke N, Fielding G. Laparoscopic right hepatectomy: surgical technique. J Gastrointest Surg. 2004;8(2):213–6.CrossRefPubMed
9.
Zurück zum Zitat Samama G, Chiche L, Bréfort JL, Le Roux Y. Laparoscopic anatomical hepatic resection. Report of four left lobectomies for solid tumors. Surg Endosc. 1998;12(1):76–8. Samama G, Chiche L, Bréfort JL, Le Roux Y. Laparoscopic anatomical hepatic resection. Report of four left lobectomies for solid tumors. Surg Endosc. 1998;12(1):76–8.
10.
Zurück zum Zitat Gumbs AA, Gayet B. Totally laparoscopic central hepatectomy. J Gastrointest Surg. 2008;12(7):1153.CrossRefPubMed Gumbs AA, Gayet B. Totally laparoscopic central hepatectomy. J Gastrointest Surg. 2008;12(7):1153.CrossRefPubMed
11.
Zurück zum Zitat Gumbs AA, Bar-Zakai B, Gayet B. Totally laparoscopic extended left hepatectomy. J Gastrointest Surg. 2008;12(7):1152.CrossRefPubMed Gumbs AA, Bar-Zakai B, Gayet B. Totally laparoscopic extended left hepatectomy. J Gastrointest Surg. 2008;12(7):1152.CrossRefPubMed
12.
Zurück zum Zitat Gamblin TC, Holloway SE, Heckman JT, Geller DA. Laparoscopic resection of benign hepatic cysts: a new standard. J Am Coll Surg. 2008;207:731–6.CrossRefPubMed Gamblin TC, Holloway SE, Heckman JT, Geller DA. Laparoscopic resection of benign hepatic cysts: a new standard. J Am Coll Surg. 2008;207:731–6.CrossRefPubMed
13.
Zurück zum Zitat Cherqui D, Laurent A, Tayar C, Chang S, Van Nhieu JT, Loriau J, et al. Laparoscopic liver resection for peripheral hepatocellular carcinoma in patients with chronic liver disease: midterm results and perspectives. Ann Surg. 2006;243(4):499–506.CrossRefPubMed Cherqui D, Laurent A, Tayar C, Chang S, Van Nhieu JT, Loriau J, et al. Laparoscopic liver resection for peripheral hepatocellular carcinoma in patients with chronic liver disease: midterm results and perspectives. Ann Surg. 2006;243(4):499–506.CrossRefPubMed
14.
Zurück zum Zitat Koffron AJ, Kung RD, Auffenberg GB, Abecassis MM. Laparoscopic liver surgery for everyone: the hybrid method. Surgery. 2007;142(4):463–8; discussion 468.e1-2.CrossRefPubMed Koffron AJ, Kung RD, Auffenberg GB, Abecassis MM. Laparoscopic liver surgery for everyone: the hybrid method. Surgery. 2007;142(4):463–8; discussion 468.e1-2.CrossRefPubMed
15.
Zurück zum Zitat Choi SB, Park JS, Kim JK, Hyung WJ, Kim KS, Yoon DS, Lee WJ, Kim BR. Early experiences of robotic-assisted laparoscopic liver resection. Yonsei Med J. 2008;49(4):632–8.CrossRefPubMed Choi SB, Park JS, Kim JK, Hyung WJ, Kim KS, Yoon DS, Lee WJ, Kim BR. Early experiences of robotic-assisted laparoscopic liver resection. Yonsei Med J. 2008;49(4):632–8.CrossRefPubMed
16.
Zurück zum Zitat Belli G, Fantini C, D’Agostino A, Cioffi L, Langella S, Russolillo N, et al. Laparoscopic versus open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: short- and middle-term results. Surg Endosc. 2007;21(11):2004–11.CrossRefPubMed Belli G, Fantini C, D’Agostino A, Cioffi L, Langella S, Russolillo N, et al. Laparoscopic versus open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: short- and middle-term results. Surg Endosc. 2007;21(11):2004–11.CrossRefPubMed
17.
Zurück zum Zitat Chen HY, Juan CC, Ker CG. Laparoscopic liver surgery for patients with hepatocellular carcinoma. Ann Surg Oncol. 2008;15(3):800–6. Epub 2007 Dec 29.CrossRefPubMed Chen HY, Juan CC, Ker CG. Laparoscopic liver surgery for patients with hepatocellular carcinoma. Ann Surg Oncol. 2008;15(3):800–6. Epub 2007 Dec 29.CrossRefPubMed
18.
Zurück zum Zitat Polignano FM, Quyn AJ, de Figueiredo RS, Henderson NA, Kulli C, Tait IS. Laparoscopic versus open liver segmentectomy: prospective, case-matched, intention-to-treat analysis of clinical outcomes and cost effectiveness. Surg Endosc. 2008 Sep 24. Epub ahead of print. Polignano FM, Quyn AJ, de Figueiredo RS, Henderson NA, Kulli C, Tait IS. Laparoscopic versus open liver segmentectomy: prospective, case-matched, intention-to-treat analysis of clinical outcomes and cost effectiveness. Surg Endosc. 2008 Sep 24. Epub ahead of print.
19.
Zurück zum Zitat Lee KF, Cheung YS, Chong CN, Tsang YY, Ng WW, Ling E, et al. Laparoscopic versus open hepatectomy for liver tumours: a case control study. Hong Kong Med J. 2007;13(6):442–8.PubMed Lee KF, Cheung YS, Chong CN, Tsang YY, Ng WW, Ling E, et al. Laparoscopic versus open hepatectomy for liver tumours: a case control study. Hong Kong Med J. 2007;13(6):442–8.PubMed
20.
Zurück zum Zitat Lesurtel M, Cherqui D, Laurent A, Tayar C, Fagniez PL. Laparoscopic versus open left lateral hepatic lobectomy: a case–control study. J Am Coll Surg. 2003;196(2):236–42.CrossRefPubMed Lesurtel M, Cherqui D, Laurent A, Tayar C, Fagniez PL. Laparoscopic versus open left lateral hepatic lobectomy: a case–control study. J Am Coll Surg. 2003;196(2):236–42.CrossRefPubMed
21.
Zurück zum Zitat Koffron A, Geller D, Gamblin TC, Abecassis M. Laparoscopic liver surgery: shifting the management of liver tumors. Hepatology. 2006;44(6):1694–700.CrossRefPubMed Koffron A, Geller D, Gamblin TC, Abecassis M. Laparoscopic liver surgery: shifting the management of liver tumors. Hepatology. 2006;44(6):1694–700.CrossRefPubMed
22.
Zurück zum Zitat Vanounou T, Pratt W, Fischer JE, Vollmer CM Jr, Callery MP. Deviation-based cost modeling: a novel model to evaluate the clinical and economic impact of clinical pathways. J Am Coll Surg. 2007;204(4):570–9.CrossRefPubMed Vanounou T, Pratt W, Fischer JE, Vollmer CM Jr, Callery MP. Deviation-based cost modeling: a novel model to evaluate the clinical and economic impact of clinical pathways. J Am Coll Surg. 2007;204(4):570–9.CrossRefPubMed
23.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–213.CrossRefPubMed Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–213.CrossRefPubMed
24.
Zurück zum Zitat Koffron AJ, Auffenberg G, Kung R, Abecassis M. Evaluation of 300 minimally invasive liver resections at a single institution: less is more. Ann Surg. 2007;246(3):385–92.CrossRefPubMed Koffron AJ, Auffenberg G, Kung R, Abecassis M. Evaluation of 300 minimally invasive liver resections at a single institution: less is more. Ann Surg. 2007;246(3):385–92.CrossRefPubMed
25.
Zurück zum Zitat Aldrighetti L, Pulitanò C, Catena M, Arru M, Guzzetti E, Casati M, et al. A prospective evaluation of laparoscopic versus open left lateral hepatic sectionectomy. J Gastrointest Surg. 2008;12(3):457–62.CrossRefPubMed Aldrighetti L, Pulitanò C, Catena M, Arru M, Guzzetti E, Casati M, et al. A prospective evaluation of laparoscopic versus open left lateral hepatic sectionectomy. J Gastrointest Surg. 2008;12(3):457–62.CrossRefPubMed
26.
Zurück zum Zitat Abu Hilal M, McPhail MJ, Zeidan B, Zeidan S, Hallam MJ, Armstrong T, et al. Laparoscopic versus open left lateral hepatic sectionectomy: a comparative study. Eur J Surg Oncol. 2008;34(12):1285–8.PubMed Abu Hilal M, McPhail MJ, Zeidan B, Zeidan S, Hallam MJ, Armstrong T, et al. Laparoscopic versus open left lateral hepatic sectionectomy: a comparative study. Eur J Surg Oncol. 2008;34(12):1285–8.PubMed
27.
Zurück zum Zitat Abdel-Atty MY, Farges O, Jagor P, Belghiti J. Laparoscopy extends the indications for liver resection in patients with cirrhosis. Br J Surg. 1999;86:1397–1400.CrossRefPubMed Abdel-Atty MY, Farges O, Jagor P, Belghiti J. Laparoscopy extends the indications for liver resection in patients with cirrhosis. Br J Surg. 1999;86:1397–1400.CrossRefPubMed
28.
Zurück zum Zitat Polignano FM, Quyn AJ, de Figueiredo RS, Henderson NA, Kulli C, Tait IS. Laparoscopic versus open liver segmentectomy: prospective, case-matched, intention-to-treat analysis of clinical outcomes and cost effectiveness. Surg Endosc. 2008;22(12):2564–70.CrossRefPubMed Polignano FM, Quyn AJ, de Figueiredo RS, Henderson NA, Kulli C, Tait IS. Laparoscopic versus open liver segmentectomy: prospective, case-matched, intention-to-treat analysis of clinical outcomes and cost effectiveness. Surg Endosc. 2008;22(12):2564–70.CrossRefPubMed
Metadaten
Titel
Comparing the Clinical and Economic Impact of Laparoscopic Versus Open Liver Resection
verfasst von
Tsafrir Vanounou, MD, MBA
Jennifer L. Steel, PhD
Kevin Tri Nguyen, MD, PhD
Allan Tsung, MD
J. Wallis Marsh, MD, MBA
David A. Geller, MD
T. Clark Gamblin, MD, MS
Publikationsdatum
01.04.2010
Verlag
Springer-Verlag
Erschienen in
Annals of Surgical Oncology / Ausgabe 4/2010
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0839-0

Weitere Artikel der Ausgabe 4/2010

Annals of Surgical Oncology 4/2010 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

CME: 2 Punkte

Prof. Dr. med. Gregor Antoniadis Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

CME: 2 Punkte

Dr. med. Benjamin Meyknecht, PD Dr. med. Oliver Pieske Das Webinar S2e-Leitlinie „Distale Radiusfraktur“ beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

CME: 2 Punkte

Dr. med. Mihailo Andric
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.