Comparison between first and second wave among critically ill COVID-19 patients admitted to a French ICU: no prognostic improvement during the second wave?
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As many countries in Europe, France faced a second wave COVID-19 pandemic since September, 2020. During the first wave, intensivists faced an unprecedented massive admission of patients with COVID-19 pneumonia requiring invasive mechanical ventilation, sometimes leading to ICUs saturation. They discovered the stereotypical course of this previously unknown disease with its own specificities including the need for deep sedation and neuromuscular blockade, the increased risk of thrombotic and hemorrhagic events [1, 2], and the prolonged duration of mechanical ventilation [3] with high rate of delirium [4]. Importantly, several randomized controlled trials conducted during this first wave highlighted the beneficial effects of early administration of glucocorticoids for critically ill COVID-19 patients [5, 6].
One can legitimately assume that the experience gained during the first wave may have contributed to a better management and outcome among critically ill COVID-19 patients admitted during the second wave.
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We therefore compared the characteristics and the outcome between patients admitted to our 41-bed COVID-19 ICU for acute respiratory failure due to COVID-19 (RT-PCR positive for SARS-CoV-2) during the first wave (from March 13th to May 27th, 2020) and those admitted to our 18-bed ICU during the second wave (from August 19th to December 7th, 2020).
COVID-19 patients without acute respiratory failure, those transferred to other ICUs or still hospitalized in ICU were not included.
Eighty-two patients were admitted during the first wave and 50 during the second wave. Comparison between first and second wave regarding patients’ characteristics, ICU scores, comorbidities, biological data, administered treatments and outcome is detailed in the Table 1. Patients did not differ between the two waves with similar age, ICU scores and comorbidities. Contrary to the first wave, all the patients admitted during the second wave received early glucocorticoids and intermediate or full-dose thromboprophylaxis at ICU admission.
Table 1
Comparison between critically ill patients with SARS-CoV-2 pneumonia admitted during the first (n = 82) and the second (n = 50) COVID-19 wave
First wave
n = 82
Second wave
n = 50
p value
Patient’s characteristics and ICU scores
Male sex
66 (81)
38 (76)
0.70
Age, years
62 [55–70]
65 [61–69]
0.20
SAPS II
33 [24–41]
29 [22–37]
0.23
SOFA
4 [3–7]
4 [3–4]
0.07
Main comorbidities
Obesity (body mass index ≥ 30 kg/m2)
37 (46)
22 (44)
0.94
Arterial hypertension
52 (63)
30 (60)
0.84
Diabetes mellitus
35 (43)
22 (44)
1.00
Ischemic cardiopathy
8 (10)
5 (10)
1.00
Cerebro-vascular disease
7 (9)
3 (6)
0.74
Chronic kidney failure
7 (9)
5 (10)
0.77
Chronic respiratory disease
18 (23)
14 (28)
0.62
Immunocompromised status
11 (13)
8 (16)
0.88
Main delays
Days between disease onset and ICU admission
8 [7–12]
10 [8–12]
0.42
> 7 days between disease onset and ICU admission
50 (64)
37 (74)
0.33
Days between hospital admission and ICU admission
2 [1–4]
3 [1–4]
0.30
Biological data at ICU admission
D-dimers (ng/mL)
2510 [1655–9222]
1665 [1060–3372]
0.04
Prothrombin time (%)
85 [74–96]
90 [83–101]
0.08
Fibrinogen (g/L)
7.6 [6.0–8.7]
7.4 [6.2–8.4]
0.75
Platelets count (G/L)
225 [170–287]
267 [199–344]
0.03
Treatment administered at ICU admission
Glucocorticoidsa
10 (12)
50 (100)
< 0.001
Intermediate or full-dose thromboprophylaxis
46 (57)
50 (100)
< 0.001
Antibiotic therapy for bacterial co-infection at ICU admission
18 (22)
14 (29)
0.52
Antiviral drugs (lopinavir-ritonavir or remdesivir)
0 (0)
0 (0)
1.00
Tocilizumab
0 (0)
0 (0)
1.00
Outcome in the ICU
Invasive mechanical ventilation (IMV)
72 (88)
32 (64)
0.01
Days between ICU admission and IMV
2 [1–3]
4 [2–5]
< 0.001
Days between disease onset and IMV
11 [8–13]
14 [11–17]
0.01
Ventilator associated pneumonia
53/72 (74)
24/32 (75)
0.97
Prone positioning
52/72 (72)
30/32 (94)
0.03
Duration of IMV
19 [10–30]
17 [8–31]
0.60
Renal replacement therapy
24 (29)
12 (27)
0.98
Vasopressor support
52 (63)
25 (53)
0.34
Thrombotic events during ICU stay
34 (42)
8 (17)
0.01
Hemorrhagic events during ICU stay
15 (18)
9 (18)
1.00
Length of ICU stay, days
16 [8–30]
14 [9–30]
0.88
Overall ICU mortality
41 (50)
26 (52)
0.96
ICU mortality among patients requiring IMV
41/72 (57)
24/32 (75)
0.13
Continuous variables are reported as median [Interquartile range] and compared between groups using the Student t test. Categorical variables are reported as numbers (percentages) and compared using χ2 test. A p value < 0.05 was considered significant
ICU, Intensive Care Unit; IMV, Invasive Mechanical Ventilation; SAPS2, Simplified Acute Physiology Score; SOFA, Sepsis-related Organ Failure Assessment
aAccording to CAPE COVID [5] (first wave) or RECOVERY [6] (second wave) protocols
Compared to the first wave, we observed a lower proportion of patients requiring invasive mechanical ventilation and a lower rate of thrombotic events. The delay between ICU admission and tracheal intubation was longer during the second wave. ICU mortality (50% vs. 52%, p = 0.96) and duration of ICU stay did not differ between the two waves.
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The Kaplan–Meier survival analysis did not show significant difference between the two waves (p = 0.90, log-rank test) (Fig. 1).
Fig. 1
Kaplan–Meier survival estimates during the 30 days following ICU admission of COVID-19 patients admitted during the first wave (blue curve) and the second wave (red curve)
×
We herein report the first study comparing the outcome of critically ill COVID-19 patients between first and second wave in France. Despite a better understanding of COVID-19 with significant treatment modification including systematic and early administration of glucocorticoids as well as intermediate/full dose thromboprophylaxis, we did not observe any decrease in ICU mortality, with still half of the patients dying in our ICU.
However, patients admitted during the second wave were less likely to require invasive mechanical ventilation with a longer delay between ICU admission and tracheal intubation, potentially related to early administration of glucocorticoids [6]. However, this longer delay questions about the higher, albeit not statistically significant, ICU mortality observed in our intubated patients during the second wave.
The lower rate of thrombotic events observed during the second wave is likely inherent to the increased intensity of thromboprophylaxis even if a lower rate of CT pulmonary angiographies during the second wave cannot be ruled out.
The strengths of our study include the similar typology and severity of the patients during both waves making relevant the comparison. Its monocenter design, implying similar criteria of ICU admission and similar criteria of tracheal intubation by the same team of intensivists during both periods, may also be considered as a strength.
Acknowledgements
We warmly acknowledge Dr Elsa Logre, Dr Radj Cally, Dr Olivia Picq, Dr Florence Sarfati, Dr Paul Desaint and all the residents who took care of the patients.
Ethics approval and consent to participate
This study was conducted in accordance with the amended Declaration of Helsinki and was approved by the Institutional Review Board (CE 2020-85) of the French Intensive Care Society on the 27th of November 2020.
Consent for publication
Not applicable.
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Competing interests
The authors declare that they have no competing interests.
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Comparison between first and second wave among critically ill COVID-19 patients admitted to a French ICU: no prognostic improvement during the second wave?
