Introduction
Methods
Study protocols
Data acquisition of CT coronary angiography
Comparison between MDCT images and IB-IVUS images
Reproducibility and reliability of HU measurement
Statistical analyses
Results
Patient characteristics
Testing study (n = 45) | Validation study (n = 80) | |
---|---|---|
Sex, n (%) | ||
Men | 36 (80) | 68 (87) |
Age, y | 67 ± 8 | 69 ± 9 |
Body mass index, (kg/m2) | 23.1 ± 3.5 | 23.4 ± 3.9 |
Heart rate, (beats/minute) | 71 ± 11 | 68 ± 13 |
Clinical history, n (%) | ||
Prior myocardial infarction | 6 (13) | 18 (14) |
Hypertension | 32 (71) | 63 (80) |
Dyslipidemia | 16 (36) | 35 (44) |
Current smoker | 5 (11) | 16 (20) |
Diabetes mellitus type 2 | 7 (16) | 19 (24) |
Medications, n (%) | ||
Antiplatelet medication | 45 (100) | 80 (100) |
Statin | 15 (33) | 33 (41) |
Nirates | 25 (56) | 53 (66) |
Calcium channel blockers | 33 (73) | 61 (76) |
Beta-blockers | 16 (36) | 30 (38) |
Insulin | 3 (7) | 11 (14) |
ACE inhibitors or ARB | 34 (76) | 53 (66) |
Laboratory parameters (mg/dl) | ||
Total cholesterol | 201 ± 29 | 193 ± 34 |
Triglycerides | 147 ± 67 | 165 ± 99 |
HDL cholesterol | 49 ± 12 | 45 ± 11 |
LDL cholesterol | 125 ± 26 | 116 ± 25 |
HbA1c | 6.2 ± 1.0 | 6.3 ± 1.1 |
Lesions, n (%) | ||
Left anterior descending branch | 21 (44) | 32 (40) |
Left circumflex branch | 10 (22) | 18 (23) |
Right coronary artery | 14 (31) | 30 (37) |
Reproducibility and reliability of HU measurement
Cut-off values for the discrimination of tissue components
Without cutoff values | With Hounsfield unit cutoff values | |||
---|---|---|---|---|
Lipid pool | Fibrosis | Calcification | Reclassified | |
Lipid pool | 38 | 16 | 0 | 16 |
Fibrosis | 12 | 49 | 0 | 12 |
Calcification | 0 | 0 | 35 | 0 |
Total | 50 | 65 | 35 | 28 |