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Erschienen in: Osteoporosis International 1/2014

01.01.2014 | Review

Comparison between various fracture risk assessment tools

verfasst von: W. D. Leslie, L. M. Lix

Erschienen in: Osteoporosis International | Ausgabe 1/2014

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Abstract

The suboptimal performance of bone mineral density as the sole predictor of fracture risk and treatment decision making has led to the development of risk prediction algorithms that estimate fracture probability using multiple risk factors for fracture, such as demographic and physical characteristics, personal and family history, other health conditions, and medication use. We review theoretical aspects for developing and validating risk assessment tools, and illustrate how these principles apply to the best studied fracture probability tools: the World Health Organization FRAX®, the Garvan Fracture Risk Calculator, and the QResearch Database’s QFractureScores. Model development should follow a systematic and rigorous methodology around variable selection, model fit evaluation, performance evaluation, and internal and external validation. Consideration must always be given to how risk prediction tools are integrated into clinical practice guidelines to support better clinical decision making and improved patient outcomes. Accurate fracture risk assessment can guide clinicians and individuals in understanding the risk of having an osteoporosis-related fracture and inform their decision making to mitigate these risks.
Literatur
1.
Zurück zum Zitat Stone KL, Seeley DG, Lui LY et al (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res 18:1947–1954PubMed Stone KL, Seeley DG, Lui LY et al (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res 18:1947–1954PubMed
2.
Zurück zum Zitat Wiktorowicz ME, Goeree R, Papaioannou A et al (2001) Economic implications of hip fracture: health service use, institutional care and cost in Canada. Osteoporos Int 12:271–278PubMed Wiktorowicz ME, Goeree R, Papaioannou A et al (2001) Economic implications of hip fracture: health service use, institutional care and cost in Canada. Osteoporos Int 12:271–278PubMed
3.
Zurück zum Zitat Papaioannou A, Adachi JD, Parkinson W et al (2001) Lengthy hospitalization associated with vertebral fractures despite control for comorbid conditions. Osteoporos Int 12:870–874PubMed Papaioannou A, Adachi JD, Parkinson W et al (2001) Lengthy hospitalization associated with vertebral fractures despite control for comorbid conditions. Osteoporos Int 12:870–874PubMed
4.
Zurück zum Zitat Center JR, Nguyen TV, Schneider D et al (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878–882PubMed Center JR, Nguyen TV, Schneider D et al (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878–882PubMed
5.
Zurück zum Zitat Johnell O, Kanis JA, Oden A et al (2004) Mortality after osteoporotic fractures. Osteoporos Int 15:38–42PubMed Johnell O, Kanis JA, Oden A et al (2004) Mortality after osteoporotic fractures. Osteoporos Int 15:38–42PubMed
6.
Zurück zum Zitat Ioannidis G, Papaioannou A, Hopman WM et al (2009) Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. CMAJ 181:265–271PubMedCentralPubMed Ioannidis G, Papaioannou A, Hopman WM et al (2009) Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. CMAJ 181:265–271PubMedCentralPubMed
7.
Zurück zum Zitat Adachi JD, Ioannidis G, Berger C et al (2001) The influence of osteoporotic fractures on health-related quality of life in community-dwelling men and women across Canada. Osteoporos Int 12:903–908PubMed Adachi JD, Ioannidis G, Berger C et al (2001) The influence of osteoporotic fractures on health-related quality of life in community-dwelling men and women across Canada. Osteoporos Int 12:903–908PubMed
8.
Zurück zum Zitat Hallberg I, Rosenqvist AM, Kartous L et al (2004) Health-related quality of life after osteoporotic fractures. Osteoporos Int 15:834–841PubMed Hallberg I, Rosenqvist AM, Kartous L et al (2004) Health-related quality of life after osteoporotic fractures. Osteoporos Int 15:834–841PubMed
9.
Zurück zum Zitat Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733PubMed Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733PubMed
10.
Zurück zum Zitat Melton LJ III (2003) Epidemiology worldwide. Endocrinol Metab Clin North Am 32:1–13PubMed Melton LJ III (2003) Epidemiology worldwide. Endocrinol Metab Clin North Am 32:1–13PubMed
11.
Zurück zum Zitat Kanis JA, Melton LJ III, Christiansen C et al (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137–1141PubMed Kanis JA, Melton LJ III, Christiansen C et al (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137–1141PubMed
12.
Zurück zum Zitat Looker AC, Wahner HW, Dunn WL et al (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468–489PubMed Looker AC, Wahner HW, Dunn WL et al (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468–489PubMed
13.
Zurück zum Zitat Kanis JA, McCloskey EV, Johansson H et al (2008) A reference standard for the description of osteoporosis. Bone 42:467–475PubMed Kanis JA, McCloskey EV, Johansson H et al (2008) A reference standard for the description of osteoporosis. Bone 42:467–475PubMed
14.
Zurück zum Zitat Johnell O, Kanis JA, Oden A et al (2005) Predictive value of BMD for hip and other fractures. J Bone Miner Res 20:1185–1194PubMed Johnell O, Kanis JA, Oden A et al (2005) Predictive value of BMD for hip and other fractures. J Bone Miner Res 20:1185–1194PubMed
15.
Zurück zum Zitat Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254–1259PubMed Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254–1259PubMed
16.
Zurück zum Zitat Cranney A, Jamal SA, Tsang JF et al (2007) Low bone mineral density and fracture burden in postmenopausal women. CMAJ 177:575–580PubMedCentralPubMed Cranney A, Jamal SA, Tsang JF et al (2007) Low bone mineral density and fracture burden in postmenopausal women. CMAJ 177:575–580PubMedCentralPubMed
17.
Zurück zum Zitat Moons KG, Kengne AP, Woodward M et al (2012) Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio)marker. Heart 98:683–690PubMed Moons KG, Kengne AP, Woodward M et al (2012) Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio)marker. Heart 98:683–690PubMed
18.
Zurück zum Zitat Moons KG, Kengne AP, Grobbee DE et al (2012) Risk prediction models: II. External validation, model updating, and impact assessment. Heart 98:691–698PubMed Moons KG, Kengne AP, Grobbee DE et al (2012) Risk prediction models: II. External validation, model updating, and impact assessment. Heart 98:691–698PubMed
19.
Zurück zum Zitat Lloyd-Jones DM (2010) Cardiovascular risk prediction: basic concepts, current status, and future directions. Circulation 121:1768–1777PubMed Lloyd-Jones DM (2010) Cardiovascular risk prediction: basic concepts, current status, and future directions. Circulation 121:1768–1777PubMed
20.
Zurück zum Zitat Nguyen TV, Eisman JA (2013) Genetic profiling and individualized assessment of fracture risk. Nat Rev Endocrinol 9:153–161PubMed Nguyen TV, Eisman JA (2013) Genetic profiling and individualized assessment of fracture risk. Nat Rev Endocrinol 9:153–161PubMed
21.
Zurück zum Zitat Janssens AC, van Duijn CM (2009) Genome-based prediction of common diseases: methodological considerations for future research. Genome Med 1:20PubMedCentralPubMed Janssens AC, van Duijn CM (2009) Genome-based prediction of common diseases: methodological considerations for future research. Genome Med 1:20PubMedCentralPubMed
22.
Zurück zum Zitat Callas PW, Pastides H, Hosmer DW (1998) Empirical comparisons of proportional hazards, Poisson, and logistic regression modeling of occupational cohort data. Am J Ind Med 33:33–47PubMed Callas PW, Pastides H, Hosmer DW (1998) Empirical comparisons of proportional hazards, Poisson, and logistic regression modeling of occupational cohort data. Am J Ind Med 33:33–47PubMed
23.
Zurück zum Zitat Datta S, DePadilla LM (2006) Feature selection and machine learning with mass spectrometry data for distinguishing cancer and non-cancer samples. Stat Meth 3:79–92 Datta S, DePadilla LM (2006) Feature selection and machine learning with mass spectrometry data for distinguishing cancer and non-cancer samples. Stat Meth 3:79–92
24.
Zurück zum Zitat Abu-Hanna A, de Keizer N (2003) Integrating classification trees with local logistic regression in Intensive Care prognosis. Artif Intell Med 29:5–23PubMed Abu-Hanna A, de Keizer N (2003) Integrating classification trees with local logistic regression in Intensive Care prognosis. Artif Intell Med 29:5–23PubMed
25.
Zurück zum Zitat Peduzzi P, Concato J, Kemper E et al (1996) A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 49:1373–1379PubMed Peduzzi P, Concato J, Kemper E et al (1996) A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 49:1373–1379PubMed
26.
Zurück zum Zitat Steyerberg EW, Eijkemans MJ, Habbema JD (1999) Stepwise selection in small data sets: a simulation study of bias in logistic regression analysis. J Clin Epidemiol 52:935–942PubMed Steyerberg EW, Eijkemans MJ, Habbema JD (1999) Stepwise selection in small data sets: a simulation study of bias in logistic regression analysis. J Clin Epidemiol 52:935–942PubMed
27.
Zurück zum Zitat Li W, Kornak J, Harris TB et al. (2009) Hip fracture risk estimation based on principal component analysis of QCT atlas: a preliminary study. Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging 7262:doi:10.1117/12.811743 Li W, Kornak J, Harris TB et al. (2009) Hip fracture risk estimation based on principal component analysis of QCT atlas: a preliminary study. Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging 7262:doi:10.1117/12.811743
28.
Zurück zum Zitat Moons KG, Donders AR, Steyerberg EW et al (2004) Penalized maximum likelihood estimation to directly adjust diagnostic and prognostic prediction models for overoptimism: a clinical example. J Clin Epidemiol 57:1262–1270PubMed Moons KG, Donders AR, Steyerberg EW et al (2004) Penalized maximum likelihood estimation to directly adjust diagnostic and prognostic prediction models for overoptimism: a clinical example. J Clin Epidemiol 57:1262–1270PubMed
29.
Zurück zum Zitat Steyerberg EW, Eijkemans MJ, Harrell FE Jr et al (2000) Prognostic modelling with logistic regression analysis: a comparison of selection and estimation methods in small data sets. Stat Med 19:1059–1079PubMed Steyerberg EW, Eijkemans MJ, Harrell FE Jr et al (2000) Prognostic modelling with logistic regression analysis: a comparison of selection and estimation methods in small data sets. Stat Med 19:1059–1079PubMed
30.
Zurück zum Zitat Nagelkerke NJD (1991) A note on a general definition of the coefficient of determination. Biomet 78:691–692 Nagelkerke NJD (1991) A note on a general definition of the coefficient of determination. Biomet 78:691–692
31.
Zurück zum Zitat Brier GW (1950) Verification of forecasts expressed in terms of probability. Monthly Weather Review:1–3 Brier GW (1950) Verification of forecasts expressed in terms of probability. Monthly Weather Review:1–3
32.
Zurück zum Zitat Blattenberger G (1985) Separating the Brier score into calibration and refinement components: a graphical exposition. Am Stat 26–32 Blattenberger G (1985) Separating the Brier score into calibration and refinement components: a graphical exposition. Am Stat 26–32
33.
Zurück zum Zitat Spiegelhalter DJ (1986) Probabilistic prediction in patient management and clinical trials. Stat Med 5:421–433PubMed Spiegelhalter DJ (1986) Probabilistic prediction in patient management and clinical trials. Stat Med 5:421–433PubMed
34.
Zurück zum Zitat Ikeda M, Ishigaki T, Yamauchi K (2002) Relationship between Brier score and area under the binormal ROC curve. Comput Methods Programs Biomed 67:187–194PubMed Ikeda M, Ishigaki T, Yamauchi K (2002) Relationship between Brier score and area under the binormal ROC curve. Comput Methods Programs Biomed 67:187–194PubMed
35.
Zurück zum Zitat Harrell FE Jr, Lee KL, Mark DB (1996) Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 15:361–387PubMed Harrell FE Jr, Lee KL, Mark DB (1996) Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 15:361–387PubMed
36.
Zurück zum Zitat DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845PubMed DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845PubMed
37.
Zurück zum Zitat Harrell FE Jr, Lee KL, Califf RM et al (1984) Regression modelling strategies for improved prognostic prediction. Stat Med 3:143–152PubMed Harrell FE Jr, Lee KL, Califf RM et al (1984) Regression modelling strategies for improved prognostic prediction. Stat Med 3:143–152PubMed
38.
Zurück zum Zitat Chambless LE, Diao G (2006) Estimation of time-dependent area under the ROC curve for long-term risk prediction. Stat Med 25:3474–3486PubMed Chambless LE, Diao G (2006) Estimation of time-dependent area under the ROC curve for long-term risk prediction. Stat Med 25:3474–3486PubMed
39.
Zurück zum Zitat Steyerberg EW, Vickers AJ, Cook NR et al (2010) Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology 21:128–138PubMedCentralPubMed Steyerberg EW, Vickers AJ, Cook NR et al (2010) Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology 21:128–138PubMedCentralPubMed
40.
Zurück zum Zitat Kanis JA, Oden A, Johansson H et al (2012) Pitfalls in the external validation of FRAX. Osteoporos Int 23:423–431PubMed Kanis JA, Oden A, Johansson H et al (2012) Pitfalls in the external validation of FRAX. Osteoporos Int 23:423–431PubMed
41.
Zurück zum Zitat Pressman AR, Lo JC, Chandra M et al (2011) Methods for assessing fracture risk prediction models: experience with FRAX in a large integrated health care delivery system. J Clin Densitom 14:407–415PubMed Pressman AR, Lo JC, Chandra M et al (2011) Methods for assessing fracture risk prediction models: experience with FRAX in a large integrated health care delivery system. J Clin Densitom 14:407–415PubMed
42.
Zurück zum Zitat Leslie WD, Lix LM (2011) Absolute fracture risk assessment using lumbar spine and femoral neck bone density measurements: derivation and validation of a hybrid system. J Bone Miner Res 26:460–467PubMed Leslie WD, Lix LM (2011) Absolute fracture risk assessment using lumbar spine and femoral neck bone density measurements: derivation and validation of a hybrid system. J Bone Miner Res 26:460–467PubMed
43.
Zurück zum Zitat Steyerberg EW, Harrell FE Jr, Borsboom GJ et al (2001) Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol 54:774–781PubMed Steyerberg EW, Harrell FE Jr, Borsboom GJ et al (2001) Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol 54:774–781PubMed
44.
Zurück zum Zitat Steyerberg EW, Bleeker SE, Moll HA et al (2003) Internal and external validation of predictive models: a simulation study of bias and precision in small samples. J Clin Epidemiol 56:441–447PubMed Steyerberg EW, Bleeker SE, Moll HA et al (2003) Internal and external validation of predictive models: a simulation study of bias and precision in small samples. J Clin Epidemiol 56:441–447PubMed
45.
Zurück zum Zitat Royston P, Altman DG (2013) External validation of a Cox prognostic model: principles and methods. BMC Med Res Methodol 13:33PubMedCentralPubMed Royston P, Altman DG (2013) External validation of a Cox prognostic model: principles and methods. BMC Med Res Methodol 13:33PubMedCentralPubMed
46.
Zurück zum Zitat Satagopan JM, Ben-Porat L, Berwick M et al (2004) A note on competing risks in survival data analysis. Br J Cancer 91:1229–1235PubMedCentralPubMed Satagopan JM, Ben-Porat L, Berwick M et al (2004) A note on competing risks in survival data analysis. Br J Cancer 91:1229–1235PubMedCentralPubMed
47.
Zurück zum Zitat Leslie WD, Lix LM, Wu X (2013) Competing mortality and fracture risk assessment. Osteoporos Int 24:681–688PubMed Leslie WD, Lix LM, Wu X (2013) Competing mortality and fracture risk assessment. Osteoporos Int 24:681–688PubMed
48.
Zurück zum Zitat Scrucca L, Santucci A, Aversa F (2007) Competing risk analysis using R: an easy guide for clinicians. Bone Marrow Transplant 40:381–387PubMed Scrucca L, Santucci A, Aversa F (2007) Competing risk analysis using R: an easy guide for clinicians. Bone Marrow Transplant 40:381–387PubMed
49.
Zurück zum Zitat Allison PD (ed) (2002) Missing data. Sage, Thousand Oaks Allison PD (ed) (2002) Missing data. Sage, Thousand Oaks
50.
Zurück zum Zitat Enders CK (ed) (2010) Applied missing data analysis. Guilford, New York Enders CK (ed) (2010) Applied missing data analysis. Guilford, New York
51.
Zurück zum Zitat Schafer JL, Graham JW (2002) Missing data: our view of the state of the art. Psychol Methods 7:147–177PubMed Schafer JL, Graham JW (2002) Missing data: our view of the state of the art. Psychol Methods 7:147–177PubMed
52.
Zurück zum Zitat Little RJA, Rubin DB (eds) (2002) Statistical analysis with missing data. Wiley, New York Little RJA, Rubin DB (eds) (2002) Statistical analysis with missing data. Wiley, New York
53.
Zurück zum Zitat Mayer B, Muche R, Hohl K (2012) Software for the handling and imputation of missing data—an overview. J Clinic Trials 2:103–111 Mayer B, Muche R, Hohl K (2012) Software for the handling and imputation of missing data—an overview. J Clinic Trials 2:103–111
54.
Zurück zum Zitat Gourlay ML, Powers JM, Lui LY et al (2008) Clinical performance of osteoporosis risk assessment tools in women aged 67 years and older. Osteoporos Int 19:1175–1183PubMedCentralPubMed Gourlay ML, Powers JM, Lui LY et al (2008) Clinical performance of osteoporosis risk assessment tools in women aged 67 years and older. Osteoporos Int 19:1175–1183PubMedCentralPubMed
55.
Zurück zum Zitat Rud B, Hilden J, Hyldstrup L et al (2009) The Osteoporosis Self-Assessment Tool versus alternative tests for selecting postmenopausal women for bone mineral density assessment: a comparative systematic review of accuracy. Osteoporos Int 20:599–607PubMed Rud B, Hilden J, Hyldstrup L et al (2009) The Osteoporosis Self-Assessment Tool versus alternative tests for selecting postmenopausal women for bone mineral density assessment: a comparative systematic review of accuracy. Osteoporos Int 20:599–607PubMed
56.
Zurück zum Zitat Schwartz EN, Steinberg DM (2006) Prescreening tools to determine who needs DXA. Curr Osteoporos Rep 4:148–152PubMed Schwartz EN, Steinberg DM (2006) Prescreening tools to determine who needs DXA. Curr Osteoporos Rep 4:148–152PubMed
57.
Zurück zum Zitat Kanis JA, Oden A, Johansson H et al (2009) FRAX and its applications to clinical practice. Bone 44:734–743PubMed Kanis JA, Oden A, Johansson H et al (2009) FRAX and its applications to clinical practice. Bone 44:734–743PubMed
59.
Zurück zum Zitat Kanis JA, Oden A, McCloskey EV et al (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239–2256PubMedCentralPubMed Kanis JA, Oden A, McCloskey EV et al (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239–2256PubMedCentralPubMed
60.
Zurück zum Zitat McCloskey E, Kanis JA (2012) FRAX updates 2012. Curr Opin Rheumatol 24:554–560PubMed McCloskey E, Kanis JA (2012) FRAX updates 2012. Curr Opin Rheumatol 24:554–560PubMed
61.
Zurück zum Zitat Kanis JA, Johnell O, Oden A et al (2000) Long-term risk of osteoporotic fracture in Malmo. Osteoporos Int 11:669–674PubMed Kanis JA, Johnell O, Oden A et al (2000) Long-term risk of osteoporotic fracture in Malmo. Osteoporos Int 11:669–674PubMed
62.
Zurück zum Zitat Kanis JA, Oden A, Johnell O et al (2001) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417–427PubMed Kanis JA, Oden A, Johnell O et al (2001) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417–427PubMed
63.
Zurück zum Zitat Kanis JA, Oden A, Johnell O et al (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 18:1033–1046PubMed Kanis JA, Oden A, Johnell O et al (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 18:1033–1046PubMed
64.
Zurück zum Zitat Sornay-Rendu E, Munoz F, Delmas PD et al (2010) The FRAX tool in French women: how well does it describe the real incidence of fracture in the OFELY cohort? J Bone Miner Res 25:2101–2107PubMed Sornay-Rendu E, Munoz F, Delmas PD et al (2010) The FRAX tool in French women: how well does it describe the real incidence of fracture in the OFELY cohort? J Bone Miner Res 25:2101–2107PubMed
65.
Zurück zum Zitat Tremollieres FA, Pouilles JM, Drewniak N et al (2010) Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J Bone Miner Res 25:1002–1009PubMedCentralPubMed Tremollieres FA, Pouilles JM, Drewniak N et al (2010) Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J Bone Miner Res 25:1002–1009PubMedCentralPubMed
66.
Zurück zum Zitat Leslie WD, Lix LM, Langsetmo L et al (2011) Construction of a FRAX((R)) model for the assessment of fracture probability in Canada and implications for treatment. Osteoporos Int 22:817–827PubMed Leslie WD, Lix LM, Langsetmo L et al (2011) Construction of a FRAX((R)) model for the assessment of fracture probability in Canada and implications for treatment. Osteoporos Int 22:817–827PubMed
67.
Zurück zum Zitat Leslie WD, Lix LM, Johansson H et al (2010) Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res 25:2350–2358PubMed Leslie WD, Lix LM, Johansson H et al (2010) Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res 25:2350–2358PubMed
68.
Zurück zum Zitat Fraser LA, Langsetmo L, Berger C et al (2011) Fracture prediction and calibration of a Canadian FRAX(R) tool: a population-based report from CaMos. Osteoporos Int 22:829–837PubMed Fraser LA, Langsetmo L, Berger C et al (2011) Fracture prediction and calibration of a Canadian FRAX(R) tool: a population-based report from CaMos. Osteoporos Int 22:829–837PubMed
69.
Zurück zum Zitat Czerwinski E, Kanis JA, Osieleniec J et al (2011) Evaluation of FRAX to characterise fracture risk in Poland. Osteoporos Int 22:2507–2512PubMed Czerwinski E, Kanis JA, Osieleniec J et al (2011) Evaluation of FRAX to characterise fracture risk in Poland. Osteoporos Int 22:2507–2512PubMed
70.
Zurück zum Zitat Tamaki J, Iki M, Kadowaki E et al (2011) Fracture risk prediction using FRAX(R): a 10-year follow-up survey of the Japanese Population-Based Osteoporosis (JPOS) Cohort Study. Osteoporos Int 22:3037–3045PubMed Tamaki J, Iki M, Kadowaki E et al (2011) Fracture risk prediction using FRAX(R): a 10-year follow-up survey of the Japanese Population-Based Osteoporosis (JPOS) Cohort Study. Osteoporos Int 22:3037–3045PubMed
71.
Zurück zum Zitat Rubin KH, Abrahamsen B, Hermann AP et al (2011) Fracture risk assessed by Fracture Risk Assessment Tool (FRAX) compared with fracture risk derived from population fracture rates. Scand J Public Health 39:312–318PubMed Rubin KH, Abrahamsen B, Hermann AP et al (2011) Fracture risk assessed by Fracture Risk Assessment Tool (FRAX) compared with fracture risk derived from population fracture rates. Scand J Public Health 39:312–318PubMed
72.
Zurück zum Zitat Premaor M, Parker RA, Cummings S et al (2013) Predictive value of FRAX for fracture in obese older women. J Bone Miner Res 28:188–195PubMedCentralPubMed Premaor M, Parker RA, Cummings S et al (2013) Predictive value of FRAX for fracture in obese older women. J Bone Miner Res 28:188–195PubMedCentralPubMed
73.
Zurück zum Zitat Ettinger B, Ensrud KE, Blackwell T et al. (2013) Performance of FRAX in a cohort of community-dwelling, ambulatory older men: the Osteoporotic Fractures in Men (MrOS) study. Osteoporos Int 24:1185–1193 Ettinger B, Ensrud KE, Blackwell T et al. (2013) Performance of FRAX in a cohort of community-dwelling, ambulatory older men: the Osteoporotic Fractures in Men (MrOS) study. Osteoporos Int 24:1185–1193
74.
Zurück zum Zitat Byberg L, Gedeborg R, Cars T et al (2012) Prediction of fracture risk in men: a cohort study. J Bone Miner Res 27:797–807PubMedCentralPubMed Byberg L, Gedeborg R, Cars T et al (2012) Prediction of fracture risk in men: a cohort study. J Bone Miner Res 27:797–807PubMedCentralPubMed
75.
Zurück zum Zitat Gonzalez-Macias J, Marin F, Vila J et al (2012) Probability of fractures predicted by FRAX(R) and observed incidence in the Spanish ECOSAP Study cohort. Bone 50:373–377PubMed Gonzalez-Macias J, Marin F, Vila J et al (2012) Probability of fractures predicted by FRAX(R) and observed incidence in the Spanish ECOSAP Study cohort. Bone 50:373–377PubMed
76.
Zurück zum Zitat Tebe Cordomi C, Del Rio LM, Di GS et al. (2013) Validation of the FRAX predictive model for major osteoporotic fracture in a historical cohort of Spanish women. J Clin Densitom 16:231–237 Tebe Cordomi C, Del Rio LM, Di GS et al. (2013) Validation of the FRAX predictive model for major osteoporotic fracture in a historical cohort of Spanish women. J Clin Densitom 16:231–237
77.
Zurück zum Zitat Dawson-Hughes B (2008) A revised clinician's guide to the prevention and treatment of osteoporosis. J Clin Endocrinol Metab 93:2463–2465PubMed Dawson-Hughes B (2008) A revised clinician's guide to the prevention and treatment of osteoporosis. J Clin Endocrinol Metab 93:2463–2465PubMed
78.
Zurück zum Zitat Dawson-Hughes B, Tosteson AN, Melton LJ III et al (2008) Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA. Osteoporos Int 19:449–458PubMed Dawson-Hughes B, Tosteson AN, Melton LJ III et al (2008) Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA. Osteoporos Int 19:449–458PubMed
79.
Zurück zum Zitat Kanis JA, Johnell O, Oden A et al (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385–397PubMedCentralPubMed Kanis JA, Johnell O, Oden A et al (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385–397PubMedCentralPubMed
80.
Zurück zum Zitat Kanis JA, McCloskey EV, Johansson H et al (2008) Case finding for the management of osteoporosis with FRAX((R))—assessment and intervention thresholds for the UK. Osteoporos Int 19:1395–1408PubMed Kanis JA, McCloskey EV, Johansson H et al (2008) Case finding for the management of osteoporosis with FRAX((R))—assessment and intervention thresholds for the UK. Osteoporos Int 19:1395–1408PubMed
81.
Zurück zum Zitat Lippuner K, Johansson H, Kanis JA et al (2010) FRAX assessment of osteoporotic fracture probability in Switzerland. Osteoporos Int 21:381–389PubMed Lippuner K, Johansson H, Kanis JA et al (2010) FRAX assessment of osteoporotic fracture probability in Switzerland. Osteoporos Int 21:381–389PubMed
82.
Zurück zum Zitat Kanis JA, Burlet N, Cooper C et al (2008) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 19:399–428PubMedCentralPubMed Kanis JA, Burlet N, Cooper C et al (2008) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 19:399–428PubMedCentralPubMed
83.
Zurück zum Zitat Fujiwara S, Kasagi F, Masunari N et al (2003) Fracture prediction from bone mineral density in Japanese men and women. J Bone Miner Res 18:1547–1553PubMed Fujiwara S, Kasagi F, Masunari N et al (2003) Fracture prediction from bone mineral density in Japanese men and women. J Bone Miner Res 18:1547–1553PubMed
84.
Zurück zum Zitat Neuprez A, Johansson H, Kanis JA et al (2009) [A FRAX model for the assessment of fracture probability in Belgium]. Rev Med Liege 64:612–619PubMed Neuprez A, Johansson H, Kanis JA et al (2009) [A FRAX model for the assessment of fracture probability in Belgium]. Rev Med Liege 64:612–619PubMed
85.
Zurück zum Zitat Papaioannou A, Morin S, Cheung AM et al (2010) 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ 182:1864–1873PubMedCentralPubMed Papaioannou A, Morin S, Cheung AM et al (2010) 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ 182:1864–1873PubMedCentralPubMed
86.
Zurück zum Zitat Kanis JA, Hans D, Cooper C et al (2011) Interpretation and use of FRAX in clinical practice. Osteoporos Int 22:2395–2411PubMed Kanis JA, Hans D, Cooper C et al (2011) Interpretation and use of FRAX in clinical practice. Osteoporos Int 22:2395–2411PubMed
87.
Zurück zum Zitat Hans DB, Kanis JA, Baim S et al (2011) Joint Official Positions of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX((R)) Executive Summary of the 2010 Position Development Conference on Interpretation and Use of FRAX((R)) in Clinical Practice. J Clin Densitom 14:171–180PubMed Hans DB, Kanis JA, Baim S et al (2011) Joint Official Positions of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX((R)) Executive Summary of the 2010 Position Development Conference on Interpretation and Use of FRAX((R)) in Clinical Practice. J Clin Densitom 14:171–180PubMed
88.
Zurück zum Zitat Lo JC, Pressman AR, Chandra M et al (2011) Fracture risk tool validation in an integrated healthcare delivery system. Am J Manag Care 17:188–194PubMed Lo JC, Pressman AR, Chandra M et al (2011) Fracture risk tool validation in an integrated healthcare delivery system. Am J Manag Care 17:188–194PubMed
89.
Zurück zum Zitat Siminoski K, Leslie WD, Frame H et al (2005) Recommendations for bone mineral density reporting in Canada. Can Assoc Radiol J 56:178–188PubMed Siminoski K, Leslie WD, Frame H et al (2005) Recommendations for bone mineral density reporting in Canada. Can Assoc Radiol J 56:178–188PubMed
90.
Zurück zum Zitat Siminoski K, Leslie WD, Frame H et al (2007) Recommendations for bone mineral density reporting in Canada: a shift to absolute fracture risk assessment. J Clin Densitom 10:120–123PubMed Siminoski K, Leslie WD, Frame H et al (2007) Recommendations for bone mineral density reporting in Canada: a shift to absolute fracture risk assessment. J Clin Densitom 10:120–123PubMed
91.
Zurück zum Zitat Leslie WD, Berger C, Langsetmo L et al. (2011) Construction and validation of a simplified fracture risk assessment tool for Canadian women and men: results from the CaMos and Manitoba cohorts. Osteoporos Int 22:1873–1883 Leslie WD, Berger C, Langsetmo L et al. (2011) Construction and validation of a simplified fracture risk assessment tool for Canadian women and men: results from the CaMos and Manitoba cohorts. Osteoporos Int 22:1873–1883
92.
Zurück zum Zitat Nguyen ND, Frost SA, Center JR et al (2007) Development of a nomogram for individualizing hip fracture risk in men and women. Osteoporos Int 18:1109–1117PubMed Nguyen ND, Frost SA, Center JR et al (2007) Development of a nomogram for individualizing hip fracture risk in men and women. Osteoporos Int 18:1109–1117PubMed
93.
Zurück zum Zitat Nguyen ND, Frost SA, Center JR et al (2008) Development of prognostic nomograms for individualizing 5-year and 10-year fracture risks. Osteoporos Int 19:1431–1444PubMed Nguyen ND, Frost SA, Center JR et al (2008) Development of prognostic nomograms for individualizing 5-year and 10-year fracture risks. Osteoporos Int 19:1431–1444PubMed
94.
Zurück zum Zitat Langsetmo L, Nguyen TV, Nguyen ND et al. (2011) Independent external validation of nomograms for predicting risk of low-trauma fracture and hip fracture. CMAJ 183:E107 Langsetmo L, Nguyen TV, Nguyen ND et al. (2011) Independent external validation of nomograms for predicting risk of low-trauma fracture and hip fracture. CMAJ 183:E107
95.
Zurück zum Zitat Hippisley-Cox J, Coupland C (2009) Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores. BMJ 339:b4229PubMedCentralPubMed Hippisley-Cox J, Coupland C (2009) Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores. BMJ 339:b4229PubMedCentralPubMed
96.
Zurück zum Zitat Hippisley-Cox J, Coupland C (2012) Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. BMJ 344:e3427PubMed Hippisley-Cox J, Coupland C (2012) Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. BMJ 344:e3427PubMed
97.
Zurück zum Zitat Collins GS, Mallett S, Altman DG (2011) Predicting risk of osteoporotic and hip fracture in the United Kingdom: prospective independent and external validation of QFractureScores. BMJ 342:d3651PubMedCentralPubMed Collins GS, Mallett S, Altman DG (2011) Predicting risk of osteoporotic and hip fracture in the United Kingdom: prospective independent and external validation of QFractureScores. BMJ 342:d3651PubMedCentralPubMed
98.
Zurück zum Zitat Cummins NM, Poku EK, Towler MR et al (2011) Clinical risk factors for osteoporosis in Ireland and the UK: a comparison of FRAX and QFractureScores. Calcif Tissue Int 89:172–177PubMed Cummins NM, Poku EK, Towler MR et al (2011) Clinical risk factors for osteoporosis in Ireland and the UK: a comparison of FRAX and QFractureScores. Calcif Tissue Int 89:172–177PubMed
99.
Zurück zum Zitat Black DM, Steinbuch M, Palermo L et al (2001) An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int 12:519–528PubMed Black DM, Steinbuch M, Palermo L et al (2001) An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int 12:519–528PubMed
100.
Zurück zum Zitat Robbins J, Aragaki AK, Kooperberg C et al (2007) Factors associated with 5-year risk of hip fracture in postmenopausal women. JAMA 298:2389–2398PubMed Robbins J, Aragaki AK, Kooperberg C et al (2007) Factors associated with 5-year risk of hip fracture in postmenopausal women. JAMA 298:2389–2398PubMed
101.
Zurück zum Zitat Henry MJ, Pasco JA, Sanders KM et al (2006) Fracture Risk (FRISK) Score: Geelong Osteoporosis Study. Radiology 241:190–196PubMed Henry MJ, Pasco JA, Sanders KM et al (2006) Fracture Risk (FRISK) Score: Geelong Osteoporosis Study. Radiology 241:190–196PubMed
102.
Zurück zum Zitat Henry MJ, Pasco JA, Merriman EN et al (2011) Fracture risk score and absolute risk of fracture. Radiology 259:495–501PubMed Henry MJ, Pasco JA, Merriman EN et al (2011) Fracture risk score and absolute risk of fracture. Radiology 259:495–501PubMed
103.
Zurück zum Zitat Pluijm SM, Koes B, de Laet C (2009) A simple risk score for the assessment of absolute fracture risk in general practice based on two longitudinal studies. J Bone Miner Res 24:768–774PubMed Pluijm SM, Koes B, de Laet C (2009) A simple risk score for the assessment of absolute fracture risk in general practice based on two longitudinal studies. J Bone Miner Res 24:768–774PubMed
104.
Zurück zum Zitat Sambrook PN, Flahive J, Hooven FH et al (2011) Predicting fractures in an international cohort using risk factor algorithms without BMD. J Bone Miner Res 26:2770–2777PubMed Sambrook PN, Flahive J, Hooven FH et al (2011) Predicting fractures in an international cohort using risk factor algorithms without BMD. J Bone Miner Res 26:2770–2777PubMed
105.
Zurück zum Zitat Bolland MJ, Siu AT, Mason BH et al (2011) Evaluation of the FRAX and Garvan fracture risk calculators in older women. J Bone Miner Res 26:420–427PubMed Bolland MJ, Siu AT, Mason BH et al (2011) Evaluation of the FRAX and Garvan fracture risk calculators in older women. J Bone Miner Res 26:420–427PubMed
106.
Zurück zum Zitat Leslie WD, Schousboe JT (2011) A review of osteoporosis diagnosis and treatment options in new and recently updated guidelines on case finding around the world. Curr Osteoporos Rep 9:129–140PubMed Leslie WD, Schousboe JT (2011) A review of osteoporosis diagnosis and treatment options in new and recently updated guidelines on case finding around the world. Curr Osteoporos Rep 9:129–140PubMed
107.
Zurück zum Zitat Compston J, Cooper A, Cooper C et al (2009) Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas 62:105–108PubMed Compston J, Cooper A, Cooper C et al (2009) Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas 62:105–108PubMed
108.
Zurück zum Zitat Kanis JA, McCloskey EV, Johansson H et al (2013) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 24:23–57PubMedCentralPubMed Kanis JA, McCloskey EV, Johansson H et al (2013) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 24:23–57PubMedCentralPubMed
110.
Zurück zum Zitat Chen P, Krege JH, Adachi JD et al (2009) Vertebral fracture status and the World Health Organization risk factors for predicting osteoporotic fracture risk. J Bone Miner Res 24:495–502PubMed Chen P, Krege JH, Adachi JD et al (2009) Vertebral fracture status and the World Health Organization risk factors for predicting osteoporotic fracture risk. J Bone Miner Res 24:495–502PubMed
111.
Zurück zum Zitat Donaldson M, Palermo L, Schousboe JT, Ensrud K, Hochberg MC, Cummings SR (2009) FRAX and risk of vertebral fractures: The Fracture Intervention Trial (FIT). J Bone Miner Res 24:1793–1799 Donaldson M, Palermo L, Schousboe JT, Ensrud K, Hochberg MC, Cummings SR (2009) FRAX and risk of vertebral fractures: The Fracture Intervention Trial (FIT). J Bone Miner Res 24:1793–1799
112.
Zurück zum Zitat Ensrud KE, Lui LY, Taylor BC et al (2009) A comparison of prediction models for fractures in older women: is more better? Arch Intern Med 169:2087–2094PubMedCentralPubMed Ensrud KE, Lui LY, Taylor BC et al (2009) A comparison of prediction models for fractures in older women: is more better? Arch Intern Med 169:2087–2094PubMedCentralPubMed
113.
Zurück zum Zitat Leslie WD, Lix LM, Johansson H et al (2011) Spine–hip discordance and fracture risk assessment: a physician-friendly FRAX enhancement. Osteoporos Int 22:839–847PubMed Leslie WD, Lix LM, Johansson H et al (2011) Spine–hip discordance and fracture risk assessment: a physician-friendly FRAX enhancement. Osteoporos Int 22:839–847PubMed
114.
Zurück zum Zitat Kanis JA, McCloskey E, Johansson H et al (2012) FRAX((R)) with and without bone mineral density. Calcif Tissue Int 90:1–13PubMed Kanis JA, McCloskey E, Johansson H et al (2012) FRAX((R)) with and without bone mineral density. Calcif Tissue Int 90:1–13PubMed
115.
Zurück zum Zitat van den BT, Heymans MW, Leone SS et al (2013) Overview of data-synthesis in systematic reviews of studies on outcome prediction models. BMC Med Res Methodol 13:42 van den BT, Heymans MW, Leone SS et al (2013) Overview of data-synthesis in systematic reviews of studies on outcome prediction models. BMC Med Res Methodol 13:42
Metadaten
Titel
Comparison between various fracture risk assessment tools
verfasst von
W. D. Leslie
L. M. Lix
Publikationsdatum
01.01.2014
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 1/2014
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-013-2409-3

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