Background
Methods
Patients and study design
Image acquisition
Cardiac iron content
Liver iron content
Iron content quantification
Reproducibility
Statistical analysis
Results
Patient characteristics and comparison with healthy volunteers
Variables | Patients | Controls |
P-value |
---|---|---|---|
N = 104 |
N = 20 | ||
Age (years) | 30 [23–53] | 35 [26–43] | 0.41 |
Gender (Male/Female) | 55/45 | 10/10 | 0.67 |
Diagnosis | |||
TM | 47 | ||
SCA | 15 | ||
Other hemoglobinopathy | 20 | ||
MDS | 4 | ||
Other | 18 | ||
1.5 T WB Heart T2* | 30.3 [22.6–36.8] | 32.3 [28.9–36.7] | 0.20 |
3 T WB Heart T2* | 18.5 [11.8–24.3] | 20.5 [18.3–24.3] | 0.14 |
1.5 T Liver T2* | 4.2 [1.8–8.6] | 25.8 [23.1–28.0] | <0.001 |
3 T Liver T2* | 2.3 [0.9–4.7] | 17.3 [14.8–21.4] | <0.001 |
Association between cardiac T2* and R2* at 1.5 T and 3 T
Association between liver T2* and R2* at 1.5 T and at 3 T
Artefact scores
Reproducibility
Heart | Liver | |||||
---|---|---|---|---|---|---|
WB | BB | |||||
CoV | ICC (95 % CI) | CoV | ICC (95 % CI) | CoV | ICC (95 % CI) | |
1.5 T | 3.19 % | 0.999 (0.998–1.000) | 1.54 % | 1.000 (0.999–1.000) | 1.98 % | 0.953 (0.890–0.980) |
3 T | 3.54 % | 0.999 (0.997–1.000) | 3.62 % | 0.999 (0.999–1.000) | 3.62 % | 0.999 (0.997–1.000) |
Heart | Liver | |||||
---|---|---|---|---|---|---|
WB | BB | |||||
CoV | ICC (95 % CI) | CoV | ICC (95 % CI) | CoV | ICC (95 % CI) | |
1.5 T | 3.34 % | 0.999 (0.998–1.000) | 2.76 % | 0.999 (0.999–1.000) | 4.24 % | 1.000 (0.999–1.000) |
3 T | 5.50 % | 0.998 (0.990–0.998) | 4.01 % | 0.999 (0.998–1.000) | 3.96 % | 0.999 (0.996–1.000) |
Cardiac | Liver | |||||
---|---|---|---|---|---|---|
WB | BB | |||||
CoV | ICC (95 % CI) | CoV | ICC (95 % CI) | CoV | ICC (95 % CI) | |
1.5 T | 5.55 % | 0.996 (0.989–0.998) | 4.55 % | 0.994 (0.985–0.998) | 5.69 % | 0.979 (0.949–0.992) |
3 T | 7.68 % | 0.970 (0.926–0.988) | 6.48 % | 0.996 (0.990–0.998) | 6.31 % | 0.998 (0.993–0.999) |
Test | Geometric Mean (95 % CI) of Squared difference |
P-value | |
---|---|---|---|
T2* BB 1.5 T | T2* BB 3 T | ||
Intra-Observer | 0.04 (0.02, 0.09) | 0.07 (0.03, 0.15) | 0.26 |
Inter-Observer | 0.04 (0.01, 0.12) | 0.07 (0.02, 0.21) | 0.18 |
Inter study | 0.26 (0.08, 0.80) | 0.28 (0.09, 0.82) | 0.94 |