Background
Methods
Registries
Study population and antiplatelet therapy
Comorbidities and concomitant medication
Outcomes
Study design
Statistical analysis
Ethics
Results
Study population
Acetylsalicylic acid | Acetylsalicylic acid + dipyridamole | Clopidogrel | p-value | |
---|---|---|---|---|
(n = 3043) | (n = 12,295) | (n = 3885) | ||
Age in years, median (IQR) | 75.3 (64.4–83.7) | 70.7 (61.5–79.6) | 68.6 (59.2–77.6) | >0.0001 |
Men (%) | 47.5 % | 56.5 % | 49.3 % | >0.0001 |
Diabetes | 380 (12.5 %) | 1449 (11.8 %) | 455 (11.7 %) | 0.5263 |
Hypertension | 1316 (43.2 %) | 4987 (40.6 %) | 1644 (42.3 %) | 0.0102 |
Myocardial infarction | 334 (11 %) | 824 (6.7 %) | 523 (13.5 %) | <0.01 |
Peripheral artery disease | 126 (4.1 %) | 297 (2.4 %) | 180 (4.6 %) | <0.01 |
Heart failure | 222 (7.3 %) | 496 (4 %) | 229 (5.9 %) | <0.01 |
Cancer | 206 (6.8 %) | 714 (5.8 %) | 245 (6.3 %) | 0.1062 |
Chronic obstructive pulmonary disease | 256 (8.4 %) | 808 (6.6 %) | 274 (7.1 %) | <0.01 |
Previous bleeding | 405 (13.3 %) | 853 (6.9 %) | 319 (8.2 %) | <0.01 |
NSAIDS | 485 (15.9 %) | 1751 (14.2 %) | 600 (15.4 %) | 0.0243 |
Time trends in antiplatelet regimens after ischemic stroke
Adherence to treatment
Baseline treatment | Proportion of patients that redeemed a prescription after 6 months of baseline drug (%) | Proportion of patients that redeemed a prescription after 12 months (%) |
---|---|---|
Clopidogrel | 91.3 | 87.5 |
Acetylsalicylic acid and dipyridamole | 92.8 (acetylsalicylic acid) | 91.7 (acetylsalicylic acid) |
89.2 (dipyridamole) | 87.3 (dipyridamole) | |
Acetylsalicylic acid | 86.0 | 85.6 |
Risk of stroke and bleeding
Risk of ischemic stroke | Risk of bleeding | |||||
---|---|---|---|---|---|---|
3 months after stroke | 6 months after stroke | 12 months after stroke | 3 months after stroke | 6 months after stroke | 12 months after stroke | |
Acetylsalicylic acid | 3.6 [3.2; 4.0] | 6.9 [6.3;7.7] | 11.1 [10.2; 12.2] | 1.2 [0.9; 1.4] | 2.0 [1.6; 2.4] | 3.4 [2.8; 3.9] |
Acetylsalicylic acid and dipyridamole | 2.4 [2.2; 2.7] | 4.7 [4.4; 5.2] | 7.7 [7.3; 8.3] | 0.8 [0.7; 0.9] | 1.4 [1.2; 1.6] | 2.4 [2.1; 2.7] |
Clopidogrel | 2.5 [2.2; 2.9] | 4.9 [4.3; 5.4] | 8.0 [6.9; 8.7] | 0.8 [0.6; 1.0] | 1.4 [1.0; 1.7] | 2.4 [1.9; 2.9] |