nach oben

Journal of Maxillofacial and Oral Surgery

05.05.2024 | ORIGINAL ARTICLE

Comparison of Clinical and Radiographic Assessment of Efficacy of Eggshell-Derived Nanohydroxyapatite (EnHA) and Demineralized Freeze-Dried Bone Allograft (DFDBA), Both Covered with Platelet-Rich Fibrin (PRF) as a Barrier Membrane in Socket Preservation: A Randomized Controlled Clinical Trial

verfasst von: Neha Nainoor, E. S. Shobha, N. T. Prashanth, Vinod Rangan, Rayan Malick, Nithin Shaju

Erschienen in: Journal of Maxillofacial and Oral Surgery

Einloggen, um Zugang zu erhalten

Abstract

Background

Bone grafting has been employed for many years to assist with bone repair. Many forms of bone graft are available which differ in their properties of osteoconduction, osteoinduction, osteogenesis, and structural support.

Purpose

The purpose of this study was to compare the efficacy of Eggshell-derived nanohydroxyapatite (EnHA) along with platelet-rich fibrin (PRF) and demineralized freeze-dried bone allograft (DFDBA) along with platelet-rich fibrin (PRF) in socket preservation of extraction sockets of mandibular molar teeth.

Study Design/Analyses

This is a double-blinded, randomized controlled clinical trial. 40 extraction sites were selected and divided into group I and group II. Group I consisted of EnHA and PRF and group II consisted of DFDBA and PRF. Each group comprising 20 extraction sites was subjected to one of the two modalities of treatment for mandibular molar extraction sockets. Postoperatively, following extraction and bone grafting, the patients were clinically evaluated for pain on 1st and 2nd day and wound healing on 7th and 14th day and were radiographically evaluated for changes in lamina dura, bone height, and bone density on an intraoral periapical radiograph taken before grafting, post grafting and at the end of 1st month and 4th month.

Results

Results showed statistically significant differences (p > 0.05) for parameters like pain and wound healing clinically and bone density, bone height, and changes in laminar dura radiographically within the groups at different intervals. However, no statistically significant difference was found between the two groups both clinically and radiographically. Our study suggested that even though both modalities used for grafting the mandibular molar extraction sockets were effective, EnHA with the PRF group appeared to be better than DFDBA with the PRF group in terms of wound healing, increase in bone height and bone density postoperatively.

Conclusion

The overall summation of results of the study concludes that EnHA with PRF seems to offer significantly better results both clinically and radiographically when compared to DFDBA with PRF in socket preservation of mandibular molar extraction sockets.

Thakkar DJ, Deshpande NC, Dave DH, Narayankar SD (2016) A comparative evaluation of extraction socket preservation with demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin: a clinical and radiographic study. Contemp Clin Dent 7:371–376. https://doi.org/10.4103/0976-237X.188567CrossRefPubMedPubMedCentral

Kattappagari KK (2019) Socket preservation using eggshell-derived nanohydroxyapatite with platelet-rich fibrin as a barrier membrane: a new technique. J Korean Assoc Oral Maxillofac Surg 45:332–342. https://doi.org/10.5125/jkaoms.2019.45.6.332CrossRefPubMedPubMedCentral

Opris H, Bran S, Dinu C, Baciut M, Prodan DA, Mester A, Baciut G (2020) Clinical applications of avian eggshellderived hydroxyapatite. Bosn J Basic Med Sci 20:430–437PubMedPubMedCentral

Cai YD, Wang SM, Chou AH, Yu LY, Sun J (2012) Zinc-coated carbonate apatite derived from avian eggshell for potential use as bone substitute. Part I: preparation and properties. Implant Dent 21:230–235. https://doi.org/10.1097/ID.0b013e3182563ce5CrossRefPubMed

Dupoirieux L, Pourquier D, Souyris F (1995) Powdered eggshell: a pilot study on a new bone substitute for use in maxillofacial surgery. J Craniomaxillofac Surg 23:187–194. https://doi.org/10.1016/s1010-5182(05)80009-5CrossRefPubMed

Lee SW, Kim SG, Balázsi C, Chae WS, Lee HO (2012) Comparative study of hydroxyapatite from eggshells and synthetic hydroxyapatite forbone regeneration. Oral Surg Oral Med Oral Pathol Oral Radiol 113:348–355. https://doi.org/10.1016/j.tripleo.2011.03.033CrossRefPubMed

Kattimani V, Lingamaneni KP, Chakravarthi PS, Kumar TS, Siddharthan A (2016) Eggshell derived hydroxyapatite: a new era in bone regeneration. J Craniofac Surg 27:112–117. https://doi.org/10.1097/SCS.0000000000002288CrossRefPubMed

Kattimani V, Lingamaneni KP, Yalamanchili S, Mupparapu M (2019) Use of eggshell-derived nano-hydroxyapatite as novel bone graft substitute-A randomized controlled clinical study. J Biomater Appl 34:597–614. https://doi.org/10.1177/0885328219863311CrossRefPubMed

Grover V, Kapoor A, Malhotra R, Sachdeva S (2011) Bone allografts: a review of safety and efficacy. Indian J Dent Res 22:496. https://doi.org/10.4103/0970-9290.87084CrossRefPubMed

10.

Kattimani VS, Prathigudupu RS, Jairaj A et al (2019) Role of synthetic hydroxyapatite—in socket preservation: a systematic review and meta-analysis. J Contemp Dent Pract 20:987–993CrossRefPubMed

11.

Checchi V, Savarino L, Montevecchi M, Felice P (2011) L: Checchi: Clinical radiographic and histological evaluation of two hydroxyapatites in human extraction sockets: a pilot study. Int J Oral Maxillofac Surg 40:526–532. https://doi.org/10.1016/j.ijom.2010.12.005CrossRefPubMed

12.

Barallat L, Ruíz-Magaz V, Levi PA Jr, Mareque-Bueno S, Galindo-Moreno P, Nart J (2014) Histomorphometric results in ridge preservation procedures comparing various graft materials in extraction sockets with nongrafted sockets in humans: a systematic review. Implant Dent 23:539–554. https://doi.org/10.1097/ID.0000000000000124CrossRefPubMed

13.

Jamjoom A, Cohen RE (2015) Grafts for ridge preservation. J Funct Biomater 7:833–848. https://doi.org/10.3390/jfb6030833CrossRef

14.

Toit JD, Gluckman H, Salama M (2015) Platelet-Rich Fibrin (PRF: A growth factor-rich biomaterial. part 1-the platelet concentrates milieu & review of the literature. Int Dent-Afr Ed 5:62–70

15.

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:37–44. https://doi.org/10.1016/j.tripleo.2005.07.008CrossRef

16.

Suttapreyasri S (2013) Leepong, N: Influence of platelet-rich fibrin on alveolar ridge preservation. J Craniofacial Surg 24:1088–1094. https://doi.org/10.1097/scs.0b013e31828b6dc3CrossRef

17.

Kattimani VS, Chakravarthi PS, Kanumuru NR, Subbarao VV, Sidharthan A, Kumar TS, Prasad LK (2014) Eggshell derived hydroxyapatite as bone graft substitute in the healing of maxillary cystic bone defects: a preliminary report. J Int Oral Health 6:15–19PubMedPubMedCentral

18.

Hamidi AA, Salimi MN, Yusoff AH (2017) Synthesis and characterization of eggshell-derived hydroxyapatite via mechanochemical method: a comparative study. AIP Conf Proc. https://doi.org/10.1063/1.4981867CrossRef

19.

Gutiérrez-Prieto SJ, Fonseca LF, Sequeda-Castañeda LG et al (2019) Elaboration and biocompatibility of an eggshell-derived hydroxyapatite material modified with Si/PLGA for bone regeneration in dentistry. Int J Dent 5:5949232. https://doi.org/10.1155/2019/5949232CrossRef

20.

Rakprasitkul S, Pairuehvej V (1997) Mandibular third molar surgery with primary closure and tube drain. Int J Oral Maxillofac Surg 26:187–190. https://doi.org/10.1016/s0901-5027(97)80817-xCrossRefPubMed

21.

Kelly WH, Mirahmadi MK, Simon JHS, Gorman JT (1980) Radiographic changes of the jawbones in end stage renal disease. Oral Surg Oral Med Oral Pathol 50:372–381. https://doi.org/10.1016/0030-4220(80)90423-5CrossRefPubMed

Titel: Comparison of Clinical and Radiographic Assessment of Efficacy of Eggshell-Derived Nanohydroxyapatite (EnHA) and Demineralized Freeze-Dried Bone Allograft (DFDBA), Both Covered with Platelet-Rich Fibrin (PRF) as a Barrier Membrane in Socket Preservation: A Randomized Controlled Clinical Trial
verfasst von: Neha Nainoor
E. S. Shobha
N. T. Prashanth
Vinod Rangan
Rayan Malick
Nithin Shaju
Publikationsdatum: 05.05.2024
Verlag: Springer India
Erschienen in: Journal of Maxillofacial and Oral Surgery
Print ISSN: 0972-8279
Elektronische ISSN: 0974-942X
DOI: https://doi.org/10.1007/s12663-024-02187-4

Neu im Fachgebiet Chirurgie

Verbände und Cremes gegen Dekubitus: „Wir wissen nicht, was sie bringen!“

17.01.2025
Dekubitus
Nachrichten

Die Datenlage zur Wirksamkeit von Verbänden oder topischen Mitteln zur Prävention von Druckgeschwüren sei schlecht, so die Verfasser einer aktuellen Cochrane-Studie. Letztlich bleibe es unsicher, ob solche Maßnahmen den Betroffenen nutzen oder schaden.

Nackenschmerzen nach Bandscheibenvorfall: Muskeltraining hilft!

15.01.2025
Nackenschmerzen
Nachrichten

Bei hartnäckigen Schmerzen aufgrund einer zervikalen Radikulopathie schlägt ein Team der Universität Istanbul vor, lokale Steroidinjektionen mit einem speziellen Trainingsprogramm zur Stabilisierung der Nackenmuskulatur zu kombinieren.

US-Team empfiehlt Gastropexie nach Hiatushernien-Op.

14.01.2025
Zwerchfellhernie
Nachrichten

Zur Vermeidung von Rezidiven nach Reparatur einer paraösophagealen Hiatushernie sollte einem US-Team zufolge der Magen bei der Op. routinemäßig an der Bauchwand fixiert werden. Das Ergebnis einer randomisierten Studie scheint dafür zu sprechen.

Mit Lidocain kommt der Darm nicht schneller in Schwung

13.01.2025
Kolektomie
Nachrichten

Verzögertes Wiederanspringen der Darmfunktion ist ein Hauptfaktor dafür, wenn Patientinnen und Patienten nach einer Kolonresektion länger als geplant im Krankenhaus bleiben müssen. Ob man diesem Problem mit Lidocain vorbeugen kann, war Thema einer Studie.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen