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Erschienen in: Journal of Anesthesia 4/2018

29.05.2018 | Original Article

Comparison of Duke Activity Status Index with cardiopulmonary exercise testing in cancer patients

verfasst von: Michael H.-G. Li, Vladimir Bolshinsky, Hilmy Ismail, Kwok-Ming Ho, Alexander Heriot, Bernhard Riedel

Erschienen in: Journal of Anesthesia | Ausgabe 4/2018

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Abstract

Purpose

The Duke Activity Status Index (DASI), a patient-administered questionnaire, is used to quantify functional capacity in patients undergoing cancer surgery.

Methods

This retrospective cohort study assessed whether the DASI was accurate in predicting peak oxygen consumption (pVO2) that was objectively measured using cardiopulmonary exercise testing (CPET) in 43 consecutive patients scheduled for elective major cancer surgery at a tertiary cancer centre. The primary outcome measured the limits of agreement between DASI-predicted pVO2 and actual measured pVO2.

Results

The study population was elderly (median 63 years, interquartile range 18), 58% were male, with the majority having intraabdominal cancer surgery. Although the DASI scores were statistically related to the measured pVO2 (N = 43, adjusted R2 = 0.20, p = 0.002), both the bias (8 ml kg− 1 min− 1) and 95% limits of agreement (19.5 to − 3.4 ml kg− 1 min− 1) between the predicted and measured pVO2 were large. Using some of the individual components, recalibrating the intercept and regression coefficient of the total DASI score did not substantially improve its ability to predict the measured pVO2.

Conclusion

In summary, both the limits of agreement and bias between the measured and DASI-predicted pVO2 were substantial. The DASI-predicted pVO2 based on patient’s assessment of their functional status could not be considered a reliable surrogate of measured pVO2 during CPET for the population of patients pending major cancer surgery and cannot, therefore, be used as a triage tool for referral to CPET centres for objective risk assessment.
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Metadaten
Titel
Comparison of Duke Activity Status Index with cardiopulmonary exercise testing in cancer patients
verfasst von
Michael H.-G. Li
Vladimir Bolshinsky
Hilmy Ismail
Kwok-Ming Ho
Alexander Heriot
Bernhard Riedel
Publikationsdatum
29.05.2018
Verlag
Springer Japan
Erschienen in
Journal of Anesthesia / Ausgabe 4/2018
Print ISSN: 0913-8668
Elektronische ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-018-2516-6

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