Background
Methods
Patients
Follow-up
Assessment of the specimens
Clinicopathological characteristics
Tumor regression grading systems
TRG system | Grade | Description |
---|---|---|
Mandard-TRG | 1 | No residual cancer |
2 | Rare residual cancer cells | |
3 | Fibrosis outgrowing residual cancer | |
4 | Residual cancer outgrowing fibrosis | |
5 | Absence of regressive changes | |
JGCA-TRG | 0 | No evidence of effect |
1a | Viable tumor cells occupy more than 2/3 of the tumorous area | |
1b | Viable tumor cells remain in more than 1/3 but less than 2/3 of the tumorous area | |
2 | Viable tumor cells remain in less than 1/3 of the tumorous area | |
3 | No viable tumor cells remain | |
CAP-TRG | 0 | No viable cancer cells (complete response) |
1 | Single cells or small groups of cancer cells (moderate response) | |
2 | Residual cancer outgrown by fibrosis (minimal response) | |
3 | Minimal or no tumor killed or extensive residual cancer (poor response) | |
China-TRG | Severe response | Tumor cells completely disappear or very few highly regressive residue exist with obvious scarring and varying inflammation |
Moderate response | Most tumor cells degenerate and necrosis with obvious stroma fibrosis and inflammation | |
Mild response | Absence of or slight necrosis and degeneration of tumor cells accompanied by mild stroma fibrosis and inflammation | |
Becker-TRG | 1a | No residual tumor/tumor bed |
1b | <10% residual tumor/tumor bed | |
2 | 10–50% residual tumor/tumor bed | |
3 | >50% residual tumor/tumor bed |
Statistical analysis
Results
Clinicopathological characteristics
Characteristics | Total cases (n = 192), no. (%) | Mandard-TRG |
P value | ||||
---|---|---|---|---|---|---|---|
1 (n = 11), no. (%) | 2 (n = 23), no. (%) | 3 (n = 40), no. (%) | 4 (n = 78), no. (%) | 5 (n = 40), no. (%) | |||
Gender | 0.039 | ||||||
Male | 139 (72.4) | 10 (7.2) | 20 (14.4) | 29 (20.9) | 48 (34.5) | 32 (23) | |
Female | 53 (27.6) | 1 (1.9) | 3 (5.7) | 11 (20.8) | 30 (56.6) | 8 (15.1) | |
Age | 0.867 | ||||||
< 55y | 89 (46.4) | 6 (6.7) | 10 (11.2) | 17 (19.1) | 39 (43.8) | 17 (19.1) | |
≥ 55y | 103 (53.6) | 5 (4.9) | 13 (12.6) | 23 (22.3) | 39 (37.9) | 23 (22.3) | |
Location | 0.351 | ||||||
Esophagogastric junction | 44 (22.9) | 1 (2.3) | 4 (9.1) | 8 (18.2) | 20 (45.5) | 11 (25) | |
Proximal gastric | 71 (37) | 7 (9.9) | 8 (11.3) | 15 (21.1) | 23 (32.4) | 18 (25.4) | |
Distal gastric | 77 (40.1) | 3 (3.9) | 11 (14.3) | 17 (22.1) | 35 (45.5) | 11 (14.3) | |
Maximal diameter of tumor bed | 0.004 | ||||||
< 4.5 cm | 108 (56.2) | 9 (8.3) | 20 (18.5) | 20 (18.5) | 44 (40.7) | 15 (13.9) | |
4.5–8 cm | 64 (33.3) | 1 (1.6) | 3 (4.7) | 17 (26.6) | 27 (42.2) | 16 (25) | |
> 8 cm | 20 (10.4) | 1 (5) | 0 (0) | 3 (15) | 7 (35) | 9 (45) | |
Histological differentiation | 0.003 | ||||||
Well-moderate | 45 (23.4) | 4 (8.9) | 12 (26.7) | 9 (20) | 16 (35.6) | 4 (8.9) | |
Poor | 147 (76.6) | 7 (4.8) | 11 (7.5) | 31 (21.1) | 62 (42.2) | 36 (24.5) | |
Laurén classification | 0.240 | ||||||
Intestinal | 77 (40.1) | 4 (5.2) | 14 (18.2) | 14 (19.2) | 28 (36.4) | 15 (19.5) | |
Diffuse | 73 (38) | 7 (9.6) | 5 (6.8) | 10 (23.8) | 33 (45.2) | 14 (19.2) | |
Mixed | 42 (21.9) | 0 (0) | 4 (9.5) | 15 (35.7) | 17 (40.5) | 11 (26.2) | |
LVI | <0.001 | ||||||
Negative | 94 (49) | 11 (11.7) | 19 (20.2) | 28 (29.8) | 26 (27.7) | 10 (10.6) | |
Positive | 98 (51) | 0 (0) | 4 (4.1) | 12 (12.2) | 52 (53.1) | 30 (30.6) | |
PNI | <0.001 | ||||||
Negative | 76 (39.6) | 11 (14.5) | 22 (28.9) | 13 (17.1) | 23 (30.3) | 7 (9.2) | |
Positive | 116 (60.4) | 0 (0) | 1 (0.9) | 27 (23.3) | 55 (47.4) | 33 (28.4) | |
AJCC ypT category | <0.001 | ||||||
0 | 11 (5.7) | 11 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
1 | 20 (10.4) | 0 (0) | 12 (60) | 5 (25) | 3 (15) | 0 (0) | |
2 | 23 (12) | 0 (0) | 5 (21.7) | 6 (26.1) | 12 (52.2) | 0 (0) | |
3 | 57 (29.7) | 0 (0) | 5 (8.8) | 18 (31.6) | 25 (43.9) | 9 (15.8) | |
4 | 81 (42.2) | 0 (0) | 1 (1.2) | 11 (13.6) | 38 (46.9) | 31 (38.3) | |
AJCC ypN category | <0.001 | ||||||
0 | 55 (28.6) | 9 (16.4) | 13 (23.6) | 17 (30.9) | 10 (18.2) | 6 (10.9) | |
1 | 36 (18.8) | 0 (0) | 6 (16.7) | 7 (19.4) | 16 (44.4) | 7 (19.4) | |
2 | 50 (26) | 0 (0) | 3 (6) | 10 (20) | 32 (64) | 5 (10) | |
3 | 51 (26.6) | 2 (3.9) | 1 (2) | 6 (11.8) | 20 (39.2) | 22 (43.1) | |
AJCC stage | <0.001 | ||||||
0 | 9 (4.7) | 9 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
1 | 24 (12.5) | 0 (0) | 14 (58.3) | 7 (29.2) | 2 (8.3) | 1 (4.2) | |
2 | 53 (27.6) | 2 (3.8) | 6 (11.3) | 14 (26.4) | 21 (39.6) | 10 (18.9) | |
3 | 106 (55.2) | 0 (0) | 3 (2.8) | 19 (17.9) | 55 (51.9) | 29 (27.4) | |
R0 resection | 0.185 | ||||||
Yes | 159 (82.8) | 11 (6.9) | 20 (12.6) | 35 (22) | 64 (40.3) | 29 (18.2) | |
No | 33 (17.2) | 0 (0) | 3 (9.1) | 5 (15.2) | 14 (42.4) | 11 (33.3) | |
Adjuvant chemotherapy | 0.766 | ||||||
Not received | 59 (30.7) | 3 (5.1) | 6 (10.2) | 10 (16.9) | 25 (42.4) | 15 (25.4) | |
Received | 133 (69.3) | 8 (6) | 17 (12.8) | 30 (22.6) | 53 (39.8) | 25 (18.8) |
Characteristics | Total cases (n = 192), no. (%) | JGCA -TRG |
P value | ||||
---|---|---|---|---|---|---|---|
3 (n = 11), no. (%) | 2 (n = 63), no. (%) | 1b (n = 45), no. (%) | 1a (n = 33), no. (%) | 0 (n = 40), no. (%) | |||
Gender | 0.097 | ||||||
Male | 139 (72.4) | 10 (7.2) | 48 (34.5) | 30 (21.6) | 19 (13.7) | 32 (23) | |
Female | 53 (27.6) | 1 (1.9) | 15 (28.3) | 15 (28.3) | 14 (26.4) | 8 (15.1) | |
Age | 0.711 | ||||||
< 55y | 89 (46.4) | 6 (6.7) | 26 (29.2) | 24 (27) | 16 (18) | 17 (19.1) | |
≥ 55y | 103 (53.6) | 5 (4.9) | 37 (35.9) | 21 (20.4) | 17 (16.5) | 23 (22.3) | |
Location | 0.287 | ||||||
Esophagogastric junction | 44 (22.9) | 1 (2.3) | 12 (27.3) | 10 (22.7) | 10 (22.7) | 11 (25) | |
Proximal gastric | 71 (37) | 7 (9.9) | 23 (32.4) | 15 (21.1) | 8 (11.3) | 18 (25.4) | |
Distal gastric | 77 (40.1) | 3 (3.9) | 28 (36.4) | 20 (26) | 15 (19.5) | 11 (14.3) | |
Maximal diameter of tumor bed | <0.001 | ||||||
< 4.5 cm | 108 (56.2) | 9 (8.3) | 40 (37) | 27 (25) | 17 (15.7) | 15 (13.9) | |
4.5–8 cm | 64 (33.3) | 1 (1.6) | 21 (32.8) | 14 (21.9) | 12 (18.8) | 16 (25) | |
> 8 cm | 20 (10.4) | 1 (5) | 2 (10) | 4 (20) | 4 (20) | 9 (45) | |
Histological differentiation | 0.060 | ||||||
Well-moderate | 45 (23.4) | 4 (8.9) | 21 (46.7) | 10 (22.2) | 6 (13.3) | 4 (8.9) | |
Poor | 147 (76.6) | 7 (4.8) | 42 (28.6) | 35 (23.8) | 27 (18.4) | 36 (24.5) | |
Laurén classification | |||||||
Intestinal | 77 (40.1) | 4 (5.2) | 29 (37.7) | 18 (23.4) | 11 (14.3) | 15 (19.5) | |
Diffuse | 73 (38) | 7 (9.6) | 20 (27.4) | 16 (21.9) | 16 (21.9) | 14 (19.2) | |
Mixed | 42 (21.9) | 0 (0) | 14 (33.3) | 11 (26.2) | 6 (14.3) | 11 (26.2) | |
LVI | <0.001 | ||||||
Negative | 94 (49) | 11 (11.7) | 46 (48.9) | 19 (20.2) | 8 (8.5) | 10 (10.6) | |
Positive | 98 (51) | 0 (0) | 17 (17.3) | 26 (26.5) | 25 (25.5) | 30 (30.6) | |
PNI | <0.001 | ||||||
Negative | 76 (39.6) | 11 (14.5) | 35 (46.1) | 14 (18.4) | 9 (11.8) | 7 (9.2) | |
Positive | 116 (60.4) | 0 (0) | 28 (24.1) | 31 (26.7) | 24 (20.7) | 33 (28.4) | |
AJCC ypT category | <0.001 | ||||||
0 | 11 (5.7) | 11 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
1 | 20 (10.4) | 0 (0) | 17 (85) | 1 (5) | 2 (10) | 0 (0) | |
2 | 23 (12) | 0 (0) | 11 (47.8) | 6 (26.1) | 6 (26.1) | 0 (0) | |
3 | 57 (29.7) | 0 (0) | 24 (42.1) | 16 (28.1) | 8 (14) | 9 (15.8) | |
4 | 81 (42.2) | 0 (0) | 11 (13.6) | 22 (27.2) | 17 (21) | 31 (38.3) | |
AJCC ypN category | <0.001 | ||||||
0 | 55 (28.6) | 9 (16.4) | 30 (54.5) | 5 (9.1) | 5 (9.1) | 6 (10.9) | |
1 | 36 (18.8) | 0 (0) | 13 (26) | 11 (30.6) | 5 (13.9) | 7 (19.4) | |
2 | 50 (26) | 0 (0) | 13 (26) | 21 (42) | 11 (22) | 5 (10) | |
3 | 51 (26.6) | 2 (3.9) | 7 (13.7) | 8 (15.7) | 12 (23.5) | 22 (43.1) | |
AJCC stage | <0.001 | ||||||
0 | 9 (4.7) | 9 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
1 | 24 (12.5) | 0 (0) | 21 (87.5) | 1 (4.2) | 1 (4.2) | 1 (4.2) | |
2 | 53 (27.6) | 2 (3.8) | 20 (37.7) | 12 (22.6) | 9 (17) | 10 (18.9) | |
3 | 106 (55.2) | 0 (0) | 22 (20.8) | 32 (30.2) | 23 (21.7) | 29 (27.4) | |
R0 resection | 0.046 | ||||||
Yes | 159 (82.8) | 11 (6.9) | 55 (34.6) | 40 (25.2) | 24 (15.1) | 29 (18.2) | |
No | 33 (17.2) | 0 (0) | 8 (24.2) | 5 (15.2) | 9 (27.3) | 11 (33.3) | |
Adjuvant chemotherapy | 0.676 | ||||||
Not received | 59 (30.7) | 3 (5.1) | 16 (27.1) | 13 (22) | 12 (20.3) | 15 (25.4) | |
Received | 133 (69.3) | 8 (6) | 47 (35.3) | 32 (24.1) | 21 (15.8) | 25 (18.8) |
Characteristics | Total cases (n = 192), no. (%) | CAP-TRG |
P value | |||
---|---|---|---|---|---|---|
0 (n = 11), no. (%) | 1 (n = 23), no. (%) | 2 (n = 40), no. (%) | 3 (n = 118), no. (%) | |||
Gender | 0.134 | |||||
Male | 139 (72.4) | 10 (7.2) | 20 (14.4) | 29 (20.9) | 80 (57.6) | |
Female | 53 (27.6) | 1 (1.9) | 3 (5.7) | 11 (20.8) | 38 (71.7) | |
Age | 0.880 | |||||
< 55y | 89 (46.4) | 6 (6.7) | 10 (11.2) | 17 (19.1) | 56 (62.9) | |
≥ 55y | 103 (53.6) | 5 (4.9) | 13 (12.6) | 23 (22.3) | 62 (60.2) | |
Location | 0.525 | |||||
Esophagogastric junction | 44 (22.9) | 1 (2.3) | 4 (9.1) | 8 (18.2) | 31 (70.5) | |
Proximal gastric | 71 (37) | 7 (9.9) | 8 (11.3) | 15 (21.1) | 41 (57.7) | |
Distal gastric | 77 (40.1) | 3 (3.9) | 11 (14.3) | 17 (22.1) | 46 (59.7) | |
Maximal diameter of tumor bed | 0.013 | |||||
< 4.5 cm | 108 (56.2) | 9 (8.3) | 20 (18.5) | 20 (18.5) | 59 (54.6) | |
4.5–8 cm | 64 (33.3) | 1 (1.6) | 3 (4.7) | 17 (26.6) | 43 (67.2) | |
> 8 cm | 20 (10.4) | 1 (5) | 0 (0) | 3 (15) | 16 (80) | |
Histological differentiation | 0.002 | |||||
Well-moderate | 45 (23.4) | 4 (8.9) | 12 (26.7) | 9 (20) | 20 (44.4) | |
Poor | 147 (76.6) | 7 (4.8) | 11 (7.5) | 31 (21.1) | 98 (66.7) | |
Laurén classification | 0.143 | |||||
Intestinal | 77 (40.1) | 4 (5.2) | 14 (18.2) | 14 (19.2) | 47 (64.4) | |
Diffuse | 73 (38) | 7 (9.6) | 5 (6.8) | 10 (23.8) | 28 (66.7) | |
Mixed | 42 (21.9) | 0 (0) | 4 (9.5) | 15 (35.7) | 23 (54.8) | |
LVI | <0.001 | |||||
Negative | 94 (49) | 11 (11.7) | 19 (20.2) | 28 (29.8) | 36 (38.3) | |
Positive | 98 (51) | 0 (0) | 4 (4.1) | 12 (12.2) | 82 (83.7) | |
PNI | <0.001 | |||||
Negative | 76 (39.6) | 11 (14.5) | 22 (28.9) | 13 (17.1) | 30 (39.5) | |
Positive | 116 (60.4) | 0 (0) | 1 (0.9) | 27 (23.3) | 88 (75.9) | |
AJCC ypT category | <0.001 | |||||
0 | 11 (5.7) | 11 (100) | 0 (0) | 0 (0) | 0 (0) | |
1 | 20 (10.4) | 0 (0) | 12 (60) | 5 (25) | 3 (15) | |
2 | 23 (12) | 0 (0) | 5 (21.7) | 6 (26.1) | 12 (52.2) | |
3 | 57 (29.7) | 0 (0) | 5 (8.8) | 18 (31.6) | 34 (59.6) | |
4 | 81 (42.2) | 0 (0) | 1 (1.2) | 11 (13.6) | 69 (85.2) | |
AJCC ypN category | <0.001 | |||||
0 | 55 (28.6) | 9 (16.4) | 13 (23.6) | 17 (30.9) | 16 (29.1) | |
1 | 36 (18.8) | 0 (0) | 6 (16.7) | 7 (19.4) | 23 (63.9) | |
2 | 50 (26) | 0 (0) | 3 (6) | 10 (20) | 37 (74) | |
3 | 51 (26.6) | 2 (3.9) | 1 (2) | 6 (11.8) | 42 (82.4) | |
AJCC stage | <0.001 | |||||
0 | 9 (4.7) | 9 (100) | 0 (0) | 0 (0) | 0 (0) | |
1 | 24 (12.5) | 0 (0) | 14 (58.3) | 7 (29.2) | 3 (12.5) | |
2 | 53 (27.6) | 2 (3.8) | 6 (11.3) | 14 (26.4) | 31 (58.5) | |
3 | 106 (55.2) | 0 (0) | 3 (2.8) | 19 (17.9) | 84 (79.2) | |
R0 resection | 0.212 | |||||
Yes | 159 (82.8) | 11 (6.9) | 20 (12.6) | 35 (22) | 93 (58.5) | |
No | 33 (17.2) | 0 (0) | 3 (9.1) | 5 (15.2) | 25 (75.8) | |
Adjuvant chemotherapy | 0.69 | |||||
Not received | 59 (30.7) | 3 (5.1) | 6 (10.2) | 10 (16.9) | 40 (67.8) | |
Received | 133 (69.3) | 8 (6) | 17 (35.3) | 30 (22.6) | 78 (58.6) |
Characteristics | Total cases (n = 192), no. (%) | China-TRG |
P value | ||
---|---|---|---|---|---|
Severe response (n = 34), no. (%) | Moderate response (n = 57), no. (%) | Mild response (n = 101), no. (%) | |||
Gender | 0.063 | ||||
Male | 139 (72.4) | 30 (21.6) | 41 (29.5) | 68 (48.9) | |
Female | 53 (27.6) | 4 (7.5) | 16 (30.2) | 33 (62.3) | |
Age | 0.820 | ||||
< 55y | 89 (46.4) | 15 (16.9) | 25 (28.1) | 49 (55.1) | |
≥ 55y | 103 (53.6) | 19 (18.4) | 32 (31.1) | 52 (50.5) | |
Location | 0.906 | ||||
Esophagogastric junction | 44 (22.9) | 6 (13.6) | 14 (31.8) | 24 (54.5) | |
Proximal gastric | 71 (37) | 14 (19.7) | 22 (31) | 35 (49.3) | |
Distal gastric | 77 (40.1) | 14 (18.2) | 21 (27.3) | 42 (54.5) | |
Maximal diameter of tumor bed | <0.001 | ||||
< 4.5 cm | 108 (56.2) | 28 (25.9) | 32 (29.6) | 48 (44.4) | |
4.5–8 cm | 64 (33.3) | 5 (7.8) | 21 (32.8) | 38 (59.4) | |
> 8 cm | 20 (10.4) | 1 (5) | 4 (20) | 15 (75) | |
Histological differentiation | 0.001 | ||||
Well-moderate | 45 (23.4) | 16 (35.6) | 12 (26.7) | 17 (37.8) | |
Poor | 147 (76.6) | 18 (12.2) | 45 (30.6) | 84 (57.1) | |
Laurén classification | 0.264 | ||||
Intestinal | 77 (40.1) | 18 (23.4) | 22 (28.6) | 37 (48.1) | |
Diffuse | 73 (38) | 13 (17.8) | 20 (27.4) | 40 (54.8) | |
Mixed | 42 (21.9) | 3 (7.1) | 15 (35.7) | 24 (57.1) | |
LVI | <0.001 | ||||
Negative | 94 (49) | 30 (31.9) | 35 (37.2) | 29 (30.9) | |
Positive | 98 (51) | 4 (4.1) | 22 (22.4) | 72 (73.5) | |
PNI | <0.001 | ||||
Negative | 76 (39.6) | 33 (43.4) | 20 (26.3) | 23 (30.3) | |
Positive | 116 (60.4) | 1 (0.9) | 37 (31.9) | 78 (67.2) | |
AJCC ypT category | <0.001 | ||||
0 | 11 (5.7) | 11 (100) | 0 (0) | 0 (0) | |
1 | 20 (10.4) | 12 (60) | 5 (25) | 3 (15) | |
2 | 23 (12) | 5 (21.7) | 8 (34.8) | 10 (43.5) | |
3 | 57 (29.7) | 5 (8.8) | 26 (45.6) | 26 (45.6) | |
4 | 81 (42.2) | 1 (1.2) | 18 (22.2) | 62 (76.5) | |
AJCC ypN category | <0.001 | ||||
0 | 55 (28.6) | 22 (40) | 18 (32.7) | 15 (27.3) | |
1 | 36 (18.8) | 5 (13.9) | 12 (33.3) | 19 (52.8) | |
2 | 50 (26) | 4 (13.9) | 19 (38) | 27 (54) | |
3 | 51 (26.6) | 3 (5.9) | 8 (15.7) | 40 (78.4) | |
AJCC stage | <0.001 | ||||
0 | 9 (4.7) | 9 (100) | 0 (0) | 0 (0) | |
1 | 24 (12.5) | 14 (58.3) | 7 (29.2) | 3 (12.5) | |
2 | 53 (27.6) | 7 (13.2) | 17 (32.1) | 29 (54.7) | |
3 | 106 (55.2) | 4 (3.8) | 33 (31.1) | 69 (65.1) | |
R0 resection | 0.1 | ||||
Yes | 159 (82.8) | 31 (19.5) | 49 (30.8) | 79 (49.7) | |
No | 33 (17.2) | 3 (9.1) | 7 (21.2) | 23 (69.7) | |
Adjuvant chemotherapy | 0.975 | ||||
Not received | 59 (30.7) | 10 (16.9) | 17 (28.8) | 32 (54.2) | |
Received | 133 (69.3) | 24 (18) | 39 (29.3) | 70 (52.6) |
Characteristics | Total cases (n = 192), no. (%) | Becker-TRG |
P value | |||
---|---|---|---|---|---|---|
1a (n = 11), no. (%) | 1b (n = 23), no. (%) | 2 (n = 67), no. (%) | 3 (n = 91), no. (%) | |||
Gender | 0.142 | |||||
Male | 139 (72.4) | 10 (7.2) | 20 (14.4) | 45 (32.4) | 64 (46) | |
Female | 53 (27.6) | 1 (1.9) | 3 (5.7) | 22 (41.5) | 27 (50.9) | |
Age | 0.945 | |||||
< 55y | 89 (46.4) | 6 (6.7) | 10 (11.2) | 31 (34.8) | 42 (47.2) | |
≥ 55y | 103 (53.6) | 5 (4.9) | 13 (12.6) | 36 (35) | 49 (47.6) | |
Location | 0.562 | |||||
Esophagogastric junction | 44 (22.9) | 1 (2.3) | 4 (9.1) | 15 (34.1) | 24 (54.5) | |
Proximal gastric | 71 (37) | 7 (9.9) | 8 (11.3) | 24 (33.8) | 32 (45.1) | |
Distal gastric | 77 (40.1) | 3 (3.9) | 11 (14.3) | 28 (36.4) | 35 (45.5) | |
Maximal diameter of tumor bed | 0.003 | |||||
< 4.5 cm | 108 (56.2) | 9 (8.3) | 20 (18.5) | 35 (32.4) | 44 (40.7) | |
4.5–8 cm | 64 (33.3) | 1 (1.6) | 3 (4.7) | 28 (43.8) | 32 (50) | |
> 8 cm | 20 (10.4) | 1 (5) | 0 (0) | 4 (20) | 15 (75) | |
Histological differentiation | 0.003 | |||||
Well-moderate | 45 (23.4) | 4 (8.9) | 12 (26.7) | 14 (31.1) | 15 (33.3) | |
Poor | 147 (76.6) | 7 (4.8) | 11 (7.5) | 53 (36.1) | 76 (51.7) | |
Laurén classification | 0.127 | |||||
Intestinal | 77 (40.1) | 4 (5.2) | 14 (18.2) | 25 (32.5) | 34 (44.2) | |
Diffuse | 73 (38) | 7 (9.6) | 5 (6.8) | 24 (32.9) | 37 (50.7) | |
Mixed | 42 (21.9) | 0 (0) | 4 (9.5) | 18 (42.9) | 20 (47.6) | |
LVI | <0.001 | |||||
Negative | 94 (49) | 11 (11.7) | 19 (20.2) | 39 (41.5) | 25 (26.6) | |
Positive | 98 (51) | 0 (0) | 4 (4.1) | 28 (28.6) | 66 (67.3) | |
PNI | <0.001 | |||||
Negative | 76 (39.6) | 11 (14.5) | 22 (28.9) | 22 (28.9) | 21 (27.6) | |
Positive | 116 (60.4) | 0 (0) | 1 (0.9) | 45 (38.8) | 70 (60.3) | |
AJCC ypT category | <0.001 | |||||
0 | 11 (5.7) | 11 (100) | 0 (0) | 0 (0) | 0 (0) | |
1 | 20 (10.4) | 0 (0) | 12 (60) | 5 (25) | 3 (15) | |
2 | 23 (12) | 0 (0) | 5 (21.7) | 10 (43.5) | 8 (34.8) | |
3 | 57 (29.7) | 0 (0) | 5 (8.8) | 29 (50.9) | 23 (40.4) | |
4 | 81 (42.2) | 0 (0) | 1 (1.2) | 23 (28.4) | 57 (70.4) | |
AJCC ypN category | <0.001 | |||||
0 | 55 (28.6) | 9 (16.4) | 13 (23.6) | 19 (34.5) | 14 (25.5) | |
1 | 36 (18.8) | 0 (0) | 6 (16.7) | 16 (44.4) | 14 (38.9) | |
2 | 50 (26) | 0 (0) | 3 (6) | 21 (42) | 26 (52) | |
3 | 51 (26.6) | 2 (3.9) | 1 (2) | 11 (21.6) | 37 (72.5) | |
AJCC stage | <0.001 | |||||
0 | 9 (4.7) | 9 (100) | 0 (0) | 0 (0) | 0 (0) | |
1 | 24 (12.5) | 0 (0) | 14 (58.3) | 7 (29.2) | 3 (12.5) | |
2 | 53 (27.6) | 2 (3.8) | 6 (11.3) | 21 (39.6) | 24 (45.3) | |
3 | 106 (55.2) | 0 (0) | 3 (2.8) | 39 (36.8) | 64 (60.4) | |
R0 resection | 0.234 | |||||
Yes | 159 (82.8) | 11 (6.9) | 20 (12.6) | 57 (35.8) | 71 (44.7) | |
No | 33 (17.2) | 0 (0) | 3 (9.1) | 10 (30.3) | 20 (60.6) | |
Adjuvant chemotherapy | 0.912 | |||||
Not received | 59 (30.7) | 3 (5.1) | 6 (10.2) | 20 (33.9) | 30 (50.8) | |
Received | 133 (69.3) | 8 (6) | 17 (35.3) | 47 (35.3) | 61 (45.9) |
Tumor regression assessment
Correlation between tumor regression and clinicopathological features
Survival analysis
Characteristics | OS | PFS | ||||
---|---|---|---|---|---|---|
HR | 95% CI |
P value | HR | 95% CI |
P value | |
Gender | ||||||
Male (reference) | 1 | 1 | ||||
Female | 1.179 | 0.740–1.876 | 0.488 | 1.309 | 0.859–1.994 | 0.211 |
Age | ||||||
< 55y (reference) | 1 | 1 | ||||
≥ 55y | 1.120 | 0.903–1.390 | 0.303 | 0.856 | 0.577–1.270 | 0.441 |
Location | ||||||
Esophagogastric junction (reference) | 1 | 1 | ||||
Proximal gastric | 0.952 | 0.555–1.632 | 0.857 | 0.829 | 0.506–1.358 | 0.456 |
Distal gastric | 0.634 | 0.360–1.117 | 0.115 | 0.631 | 0.380–1.046 | 0.074 |
Maximal diameter of tumor bed | 1.712 | 1.275–2.299 | <0.001 | 1.709 | 1.304–2.239 | <0.001 |
Histological differentiation | 3.057 | 1.617–5.782 | 0.001 | 2.667 | 1.513–4.699 | 0.001 |
Laurén classification | ||||||
Intestinal (reference) | 1 | 1 | ||||
Diffuse | 2.228 | 1.339–3.709 | 0.002 | 1.896 | 1.199–2.999 | 0.006 |
Mixed | 2.206 | 1.216–4.003 | 0.009 | 1.911 | 1.113–3.280 | 0.019 |
LVI | 3.318 | 2.089–5.270 | <0.001 | 3.324 | 2.180–5.069 | <0.001 |
PNI | 2.878 | 1.750–4.733 | <0.001 | 2.724 | 1.737–4.271 | <0.001 |
AJCC ypT category | 1.876 | 1.457–2.415 | <0.001 | 1.739 | 1.396–2.168 | <0.001 |
AJCC ypN category | 1.946 | 1.572–2.408 | <0.001 | 1.918 | 1.578–2.330 | <0.001 |
AJCC stage | 2.484 | 1.724–3.580 | <0.001 | 2.270 | 1.650–3.122 | <0.001 |
Mandard-TRG | ||||||
1 (reference) | 1 | 1 | ||||
2 | 0.98 | 0.244–3.929 | 0.977 | 1.293 | 0.343–4.877 | 0.704 |
3 | 1.956 | 0.568–6.730 | 0.287 | 2.143 | 0.631–7.283 | 0.222 |
4 | 2.717 | 0.836–8.831 | 0.096 | 3.155 | 0.979–10.168 | 0.054 |
5 | 3.682 | 1.094–12.394 | 0.035 | 4.570 | 1.380–15.132 | 0.013 |
JGCA-TRG | ||||||
3 (reference) | 1 | 1 | ||||
2 | 1.531 | 0.457–5.126 | 0.49 | 1.782 | 0.539–5.892 | 0.344 |
1b | 2.626 | 0.781–8.831 | 0.119 | 2.621 | 0.786–8.738 | 0.117 |
1a | 2.875 | 0.836–9.884 | 0.094 | 4.022 | 1.199–13.491 | 0.024 |
0 | 3.676 | 1.092–12.371 | 0.035 | 4.556 | 1.376–15.085 | 0.013 |
CAP-TRG | ||||||
0 (reference) | 1 | 1 | ||||
1 | 0.979 | 0.244–3.927 | 0.977 | 1.292 | 0.343–4.873 | 0.705 |
2 | 1.953 | 0.568–6.719 | 0.288 | 2.140 | 0.630–7.272 | 0.223 |
3 | 2.996 | 0.937–9.586 | 0.064 | 3.558 | 1.119–11.311 | 0.032 |
China-TRG | ||||||
Severe response (reference) | 1 | 1 | ||||
Moderate response | 1.719 | 0.808–3.657 | 0.160 | 1.661 | 0.834–3.308 | 0.149 |
Mild response | 2.856 | 1.450–5.628 | 0.002 | 2.868 | 1.544–5.328 | 0.001 |
Becker-TRG | ||||||
1a (reference) | 1 | 1 | ||||
1b | 0.980 | 0.244–3.927 | 0.977 | 1.292 | 0.343–4.872 | 0.705 |
2 | 2.216 | 0.673–7.294 | 0.190 | 2.295 | 0.702–7.502 | 0.169 |
3 | 3.109 | 0.964–10.028 | 0.058 | 3.964 | 1.239–12.681 | 0.020 |
R0 resection | ||||||
Yes (reference) | 1 | 1 | ||||
No | 3.382 | 2.022–5.659 | <0.001 | 3.656 | 2.315–5.774 | <0.001 |
Adjuvant chemotherapy | ||||||
Not received (reference) | 1 | 1 | ||||
Received | 1.040 | 0.633–1.707 | 0.878 | 1.227 | 0.774–1.943 | 0.384 |
Characteristics | OS | PFS | ||||
---|---|---|---|---|---|---|
HR | 95% CI |
P value | HR | 95% CI |
P value | |
Histological differentiation | - | - | - | 1.662 | 0.914–3.022 | 0.096 |
LVI | 1.651 | 0.976–2.793 | 0.062 | 1.766 | 1.091–2.861 | 0.021 |
AJCC ypT category | 1.355 | 1.029–1.784 | 0.031 | - | - | - |
AJCC ypN category | 1.487 | 1.168–1.894 | 0.001 | 1.479 | 1.180–1.855 | <0.001 |
R0 resection | 2.386 | 1.398–4.073 | 0.001 | 2.457 | 1.516–3.985 | <0.001 |
TRG systems | Median for survival time | |
---|---|---|
OS | PFS | |
Mandard-TRG | ||
1 | Not reached | Not reached |
2 | 84.4 | Not reached |
3 | 51.8 | 42.4 |
4 | 38.7 | 22.1 |
5 | 24.3 | 12.8 |
JGCA-TRG | ||
3 | Not reached | Not reached |
2 | 57.8 | 51.8 |
1b | 38.7 | 29.3 |
1a | 30.8 | 9.6 |
0 | 24.3 | 12.8 |