Multidetector computed tomography (MDCT) and cardiac magnetic resonance (CMR) are advanced, state-of-the-art imaging tools for detection of coronary artery disease (CAD), providing important complementary information in patients with suspected or established disease. While MDCT coronary angiography is an anatomical method and seems to be especially prepared for CAD detection, even in subclinical phases, CMR allows evaluation of ischemia and myocardial scar and is particularly efficient in the assessment of the functional significance of CAD and in guiding management. Over the last years, research focused on the development of anatomical and functional integrated techniques using both methods. While CMR coronary angiography is slowly but steadily developing, MDCT myocardial perfusion and MDCT virtual fractional flow reserve estimation are promising tools that may change the way noninvasive assessment of CAD is made in the near future. This review article focuses on CMR and MDCT ability for assessing CAD significance, taking into account the relevant research published in recent years.