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European Journal of Nuclear Medicine and Molecular Imaging

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03.08.2020 | Image of the Month

Comparison of PET/CT imaging with [¹⁸F]FDOPA and cholecystokinin-2 receptor targeting [⁶⁸Ga]Ga-DOTA-MGS5 in a patient with advanced medullary thyroid carcinoma

verfasst von: Christian Uprimny, Elisabeth von Guggenberg, Anna Svirydenka, Renata Mikołajczak, Alicja Hubalewska-Dydejczyk, Irene Johanna Virgolini

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 3/2021

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Excerpt

[¹⁸F]fluorodihydroxyphenylalanin ([¹⁸F]FDOPA)-PET/CT is considered the most useful imaging modality in evaluating patients with recurrent medullary thyroid carcinoma (MTC) [1, 2]. MTC cells show high expression of cholecystokinin-2 receptors (CCK2R) [3, 4]. Probes targeting CCK2R, such as ⁶⁸Ga-labelled minigastrin analogues, therefore have great potential in detecting MTC lesions [4]. …

Giovanella L, Treglia G, Iakovou I, Mihailovic J, Verburg FA, Luster M. EANM practice guideline for PET/CT imaging in medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging. 2020;47(1):61–77. https://doi.org/10.1007/s00259-019-04458-6.CrossRefPubMed

Treglia G, Castaldi P, Villani MF, Perotti G, Waure C, Filice A, et al. Comparison of 18F-DOPA, 18F-FDG and 68Ga-somatostatin analogue PET/CT in patients with recurrent medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging. 2012;39(4):569–80. https://doi.org/10.1007/s00259-011-2031-6.CrossRefPubMed

Reubi JC, Targeting CCK. Receptors in human cancers. Curr Top Med Chem. 2007;7(12):1239–42. https://doi.org/10.2174/156802607780960546.CrossRefPubMed

Reubi JC, Waser B. Unexpected high incidence of cholecystokinin-B/gastrin receptors in human medullary thyroid carcinomas. Int J Cancer. 1996;67(5):644–7. https://doi.org/10.1002/(SICI)1097-0215(19960904)67:5<644::AID-IJC9>3.0.CO;2-U.CrossRefPubMed

Klingler M, Summer D, Rangger C, Haubner R, Foster J, Sosabowski J, et al. DOTA-MGS5, a new cholecystokinin-2 receptor-targeting peptide analog with an optimized targeting profile for theranostic use. J Nucl Med. 2019;60(7):1010–6. https://doi.org/10.2967/jnumed.118.221283.CrossRefPubMedPubMedCentral

Titel: Comparison of PET/CT imaging with [18F]FDOPA and cholecystokinin-2 receptor targeting [68Ga]Ga-DOTA-MGS5 in a patient with advanced medullary thyroid carcinoma
verfasst von: Christian Uprimny
Elisabeth von Guggenberg
Anna Svirydenka
Renata Mikołajczak
Alicja Hubalewska-Dydejczyk
Irene Johanna Virgolini
Publikationsdatum: 03.08.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 3/2021
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-020-04963-z

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Comparison of PET/CT imaging with [¹⁸F]FDOPA and cholecystokinin-2 receptor targeting [⁶⁸Ga]Ga-DOTA-MGS5 in a patient with advanced medullary thyroid carcinoma

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Whole-body voxel-based internal dosimetry using deep learning

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To everything there is a season: taxonomy of approaches to the performance of lung scintigraphy in the era of COVID-19

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