Background
Methods
Cells, viruses, antibody
Serum samples
Sero-typea
| Patient ID | Diagnosis of HFRSb
| Reciprocal PRNT titrec
| Reciprocal MNT titrec
| Reciprocal PPNT titrec
| Reciprocal IFA titrec
| |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acute serum | Convalescent serum | IC50 | IC80 | IC50 | IC80 | IC50 | IC80 | IFA-virus | IFA-GP | ||||||||||||||
IgM | IgG | RNA | IgG | SEOV | HTNV | SEOV | HTNV | SEOV | HTNV | SEOV | HTNV | SEOV | HTNV | VSV | SEOV | HTNV | VSV | SEOV | HTNV | SEOV | HTNV | ||
HTN | SD11 | + | + | NT | + | 20 | 80 | <20 | 20 | 20 | 80 | <20 | 20 | 80 | 320 | <20 | 20 | 80 | <20 | 80 | 320 | 20 | 80 |
JX46 | + | + | − | + | <20 | 80 | <20 | 20 | <20 | 80 | <20 | 80 | 80 | 320 | <20 | 20 | 80 | <20 | 80 | 80 | 80 | 80 | |
SD15 | + | + | NT | + | <20 | 80 | <20 | 20 | <20 | 80 | <20 | 80 | 80 | 320 | <20 | 20 | 80 | <20 | 80 | 80 | 20 | 80 | |
LN264 | + | − | NT | + | <20 | 80 | <20 | 20 | <20 | 80 | <20 | 20 | 20 | 320 | <20 | 20 | 80 | <20 | 80 | 80 | <20 | 20 | |
JX11 | + | + | − | + | 20 | 80 | <20 | 80 | <20 | 80 | <20 | 80 | 20 | 320 | 20 | <20 | 80 | <20 | 80 | 80 | 20 | 80 | |
JX16 | + | − | − | + | 20 | 320 | <20 | 80 | 20 | 320 | <20 | 80 | 80 | 1280 | <20 | 20 | 320 | <20 | 80 | 80 | 20 | 80 | |
JX53 | + | + | − | + | 20 | 320 | <20 | 80 | 20 | 320 | 20 | 80 | 80 | 320 | <20 | 20 | 80 | <20 | 20 | 20 | 20 | 80 | |
JX39 | + | + | − | + | 20 | 320 | <20 | 80 | <20 | 320 | <20 | 80 | 20 | 1280 | <20 | 20 | 320 | <20 | 80 | 80 | 20 | 80 | |
JX36 | + | + | − | + | <20 | 320 | <20 | 80 | <20 | 320 | <20 | 80 | 20 | 320 | 20 | 20 | 80 | <20 | 80 | 320 | 20 | 80 | |
SD7 | + | + | − | + | <20 | 320 | <20 | 80 | <20 | 320 | <20 | 80 | 320 | 320 | <20 | 80 | 80 | <20 | <20 | 80 | 80 | 80 | |
SD14 | + | + | − | + | <20 | 320 | <20 | 80 | <20 | 320 | <20 | 80 | 80 | 1280 | <20 | 20 | 320 | <20 | <20 | 80 | 20 | 80 | |
SD39 | + | + | − | + | <20 | 320 | <20 | 80 | <20 | 80 | <20 | 80 | 80 | 320 | <20 | 20 | 80 | <20 | 80 | 80 | 20 | 80 | |
SD21 | + | + | H+ | + | 20 | 320 | 20 | 80 | <20 | 320 | <20 | 80 | 320 | 1280 | <20 | 80 | 320 | <20 | 320 | 320 | 80 | 80 | |
SD31 | + | + | − | + | 20 | 320 | <20 | 80 | 20 | 320 | <20 | 80 | 320 | 5120 | <20 | 80 | 320 | <20 | 1280 | 1280 | 80 | 320 | |
SD38 | + | + | − | + | <20 | 320 | <20 | 80 | <20 | 320 | <20 | 80 | 80 | 1280 | <20 | 20 | 320 | <20 | 80 | 80 | 20 | 80 | |
JX12 | + | + | − | + | <20 | 320 | <20 | 80 | <20 | 320 | <20 | 80 | 80 | 1280 | <20 | 20 | 320 | <20 | 20 | 20 | 20 | 80 | |
JX60 | + | + | NT | + | 20 | 1280 | <20 | 320 | 20 | 1280 | <20 | 320 | 80 | 5120 | <20 | 20 | 1280 | <20 | 320 | 320 | 80 | 320 | |
JX35 | + | + | − | + | <20 | 1280 | <20 | 320 | 20 | 1280 | <20 | 320 | 320 | 1280 | <20 | 80 | 320 | <20 | 80 | 80 | 20 | 80 | |
SD27 | + | + | − | + | 20 | 1280 | 20 | 320 | 20 | 5120 | 20 | 1280 | 80 | 5120 | <20 | 20 | 1280 | <20 | 80 | 320 | 80 | 320 | |
SD25 | + | + | − | + | 80 | 1280 | 20 | 320 | 80 | 1280 | 20 | 320 | 320 | 1280 | <20 | 80 | 320 | <20 | 320 | 320 | 80 | 320 | |
SD33 | + | − | − | + | 80 | 1280 | 20 | 320 | 20 | 1280 | <20 | 320 | 320 | 1280 | <20 | 80 | 320 | <20 | 320 | 320 | 80 | 320 | |
SD36 | + | + | − | + | <20 | 1280 | <20 | 320 | 20 | 1280 | <20 | 320 | 320 | 1280 | <20 | 80 | 320 | <20 | 80 | 80 | 80 | 80 | |
SD26 | + | + | − | + | <20 | 1280 | <20 | 320 | <20 | 1280 | <20 | 320 | 80 | 1280 | <20 | 20 | 320 | <20 | 20 | 80 | 20 | 80 | |
JX3 | + | + | − | + | 20 | 1280 | <20 | 320 | <20 | 1280 | <20 | 320 | 80 | 1280 | <20 | 20 | 320 | <20 | 320 | 320 | 80 | 320 | |
SD29 | + | + | H+ | + | 80 | 1280 | 20 | 320 | 20 | 1280 | 20 | 320 | 320 | 5120 | 20 | 80 | 1280 | <20 | 80 | 320 | 20 | 80 | |
SD20 | + | + | − | + | 320 | 1280 | 80 | 320 | 320 | 1280 | 80 | 320 | 1280 | 5120 | <20 | 320 | 1280 | <20 | 80 | 80 | 320 | 320 | |
LN34 | + | + | NT | + | 1280 | 20,480 | 320 | 5120 | 1280 | 20,480 | 320 | 5120 | 5120 | 20,480 | 20 | 1280 | 5120 | <20 | 320 | 320 | 5120 | 5120 | |
SEO | LN216 | + | + | NT | + | 80 | 20 | 20 | <20 | 320 | 20 | 80 | <20 | 320 | 80 | <20 | 80 | 20 | <20 | 80 | 80 | 80 | 20 |
LN28 | + | − | NT | + | 80 | 20 | 20 | <20 | 80 | 20 | 20 | 20 | 80 | <20 | <20 | 20 | <20 | <20 | 320 | 80 | 80 | <20 | |
LN266 | + | + | NT | + | 80 | 20 | 20 | <20 | 320 | <20 | 80 | <20 | 320 | 80 | <20 | 80 | 20 | <20 | 80 | 80 | 80 | 20 | |
LN265 | + | + | − | + | 80 | 20 | 20 | 20 | 80 | 20 | 80 | 20 | 320 | 20 | <20 | 80 | <20 | <20 | 80 | 80 | 80 | <20 | |
LN263 | + | + | − | + | 80 | 20 | 20 | 20 | 320 | <20 | 80 | <20 | 320 | 80 | <20 | 80 | 20 | <20 | 80 | 80 | 80 | <20 | |
LN262 | + | + | S+ | + | 80 | 20 | 20 | 20 | 320 | <20 | 80 | <20 | 1280 | <20 | <20 | 320 | <20 | <20 | 320 | 80 | 320 | 20 | |
JX1 | + | − | − | + | 320 | 20 | 80 | 20 | 320 | 20 | 80 | <20 | 1280 | 80 | 20 | 80 | 20 | <20 | 320 | 320 | 80 | 20 | |
SD4 | + | + | − | + | 320 | 80 | 80 | 20 | 320 | 20 | 320 | <20 | 1280 | 20 | 20 | 320 | <20 | <20 | 80 | 80 | 80 | <20 | |
SD2 | + | + | − | + | 320 | 20 | 80 | <20 | 320 | <20 | 80 | <20 | 320 | <20 | 20 | 80 | <20 | <20 | 320 | 320 | 80 | <20 | |
JX41 | + | + | NT | + | 320 | <20 | 80 | <20 | 1280 | <20 | 320 | <20 | 320 | 80 | <20 | 80 | 20 | <20 | 80 | 20 | 80 | 20 | |
SD30 | + | + | − | + | 320 | <20 | 80 | <20 | 320 | <20 | 80 | <20 | 1280 | 20 | 20 | 320 | <20 | <20 | 80 | 20 | 80 | 20 | |
SD1 | + | + | S+ | + | 320 | <20 | 80 | <20 | 320 | 20 | 320 | 20 | 1280 | 20 | <20 | 320 | <20 | <20 | 320 | 320 | 320 | 80 | |
LN27 | + | + | NT | + | 1280 | 20 | 320 | <20 | 1280 | <20 | 320 | <20 | 1280 | <20 | <20 | 320 | <20 | <20 | 1280 | 80 | 320 | 20 | |
LN249 | + | + | S+ | + | 1280 | 320 | 320 | 80 | 1280 | 80 | 1280 | 20 | 5120 | 80 | <20 | 1280 | 20 | <20 | 320 | 320 | 1280 | 320 | |
SD37 | + | + | − | + | 5120 | 320 | 5120 | 80 | 20,480 | 1280 | 5120 | 320 | 20,480 | 320 | 20 | 5120 | 80 | <20 | 80 | 80 | 1280 | 320 | |
Unknown | JX22 | + | + | NT | + | 20 | 20 | <20 | <20 | <20 | 20 | <20 | 20 | 80 | 80 | <20 | 20 | 20 | <20 | 80 | 80 | 20 | 20 |
SD40 | + | + | − | + | 320 | 320 | 80 | 80 | 320 | 320 | 80 | 80 | 1280 | 1280 | 20 | 320 | 320 | <20 | 80 | 80 | 80 | 80 |