nach oben

International Ophthalmology

Erschienen in:

17.05.2020 | Original Paper

Comparison of the efficacy of nepafenac 0.1% in quiescent Behçet’s uveitis and non-uveitic healthy patients after phacoemulsification surgery

verfasst von: Mehmed Uğur Işık, Nilüfer F. Yalçındağ

Erschienen in: International Ophthalmology | Ausgabe 9/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To compare the efficacy of nepafenac on anterior chamber flare and intraocular pressure(IOP) in healthy (group 1) and uveitic eyes (group 2) undergoing cataract surgery.

Methods

A retrospective, consecutive case series study.

Results

Among 54 the patients, 14 had a history of uveitis. The groups were similar in age and gender. There were significant changes in flare values in both groups. When the temporal changes of flare values were compared, there was no difference between the two groups. There were no significant changes in IOP values in both group. When the temporal changes of IOP values were compared, there was no difference between the groups.

Conclusions

Nepafenac 0.1% has been shown to be effective in suppressing inflammation after cataract surgery in uveitic eyes as well as in healthy eyes. In addition, it has been observed that it does not increase intraocular pressure in both healthy and uveitic eyes and it is safe to use with this regard.

Congdon N, Vingerling JR, Klein BE, West S, Friedman DS, Kempen J, O'Colmain B, Wu SY, Taylor HR, Eye Diseases Prevalence Research G (2004) Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol 122(4):487–494. https://doi.org/10.1001/archopht.122.4.487CrossRef

Mangione CM, Phillips RS, Lawrence MG, Seddon JM, Orav EJ, Goldman L (1994) Improved visual function and attenuation of declines in health-related quality of life after cataract extraction. Arch Ophthalmol 112(11):1419–1425. https://doi.org/10.1001/archopht.1994.01090230033017PubMedCrossRef

McGwin G Jr, Scilley K, Brown J, Owsley C (2003) Impact of cataract surgery on self-reported visual difficulties: comparison with a no-surgery reference group. J Cataract Refract Surg 29(5):941–948. https://doi.org/10.1016/s0886-3350(02)01846-1PubMedCrossRef

Sandoval HP, Fernandez de Castro LE, Vroman DT, Solomon KD (2007) A review of the use of ketorolac tromethamine 0.4% in the treatment of post-surgical inflammation following cataract and refractive surgery. Clin Ophthalmol 1(4):367–371PubMedPubMedCentral

Kim SJ, Flach AJ, Jampol LM (2010) Nonsteroidal anti-inflammatory drugs in ophthalmology. Surv Ophthalmol 55(2):108–133. https://doi.org/10.1016/j.survophthal.2009.07.005PubMedCrossRef

O'Brien TP (2005) Emerging guidelines for use of NSAID therapy to optimize cataract surgery patient care. Curr Med Res Opin 21(7):1131–1137. https://doi.org/10.1185/030079905X50651PubMedCrossRef

Wolf EJ, Braunstein A, Shih C, Braunstein RE (2007) Incidence of visually significant pseudophakic macular edema after uneventful phacoemulsification in patients treated with nepafenac. J Cataract Refract Surg 33(9):1546–1549. https://doi.org/10.1016/j.jcrs.2007.05.018PubMedCrossRef

Tugal-Tutkun I, Herbort CP (2010) Laser flare photometry: a noninvasive, objective, and quantitative method to measure intraocular inflammation. Int Ophthalmol 30(5):453–464. https://doi.org/10.1007/s10792-009-9310-2PubMedCrossRef

Isik MU, Yalcindag N (2020) Comparison of spectral domain optical coherence tomography (SD OCT) Findings with Laser Flare Photometry (LFP) Measurements in Behcet's Uveitis. Ocul Immunol Inflamm 28(2):194–199. https://doi.org/10.1080/09273948.2018.1552976PubMedCrossRef

10.

Ahuja M, Dhake AS, Sharma SK, Majumdar DK (2008) Topical ocular delivery of NSAIDs. AAPS J 10(2):229–241. https://doi.org/10.1208/s12248-008-9024-9PubMedPubMedCentralCrossRef

11.

Colin J (2007) The role of NSAIDs in the management of postoperative ophthalmic inflammation. Drugs 67(9):1291–1308. https://doi.org/10.2165/00003495-200767090-00004PubMedCrossRef

12.

Schalnus R (2003) Topical nonsteroidal anti-inflammatory therapy in ophthalmology. Ophthalmologica 217(2):89–98. https://doi.org/10.1159/000068563PubMedCrossRef

13.

Abel R Jr, Abel AD (1997) Perioperative antibiotic, steroid, and nonsteroidal anti-inflammatory agents in cataract intraocular lens surgery. Curr Opin Ophthalmol 8(1):29–32PubMedCrossRef

14.

Tzelikis PF, Vieira M, Hida WT, Motta AF, Nakano CT, Nakano EM, Alves MR (2015) Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of cystoid macular oedema after phacoemulsification: prospective placebo-controlled randomised study. Br J Ophthalmol 99(5):654–658. https://doi.org/10.1136/bjophthalmol-2014-305803PubMedCrossRef

15.

Lane SS (2006) Nepafenac: a unique nonsteroidal prodrug. Int Ophthalmol Clin 46(4):13–20. https://doi.org/10.1097/01.iio.0000212129.53019.49PubMedCrossRef

16.

Wilson DJ, Schutte SM, Abel SR (2015) Comparing the efficacy of ophthalmic NSAIDs in common indications: a literature review to support cost-effective prescribing. Ann Pharmacother 49(6):727–734. https://doi.org/10.1177/1060028015574593PubMedCrossRef

17.

Lane SS, Modi SS, Lehmann RP, Holland EJ (2007) Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery. J Cataract Refract Surg 33(1):53–58. https://doi.org/10.1016/j.jcrs.2006.08.043CrossRef

18.

Nardi M, Lobo C, Bereczki A, Cano J, Zagato E, Potts S, Sullins G, Notivol R (2007) Analgesic and anti-inflammatory effectiveness of nepafenac 0.1% for cataract surgery. Clin Ophthalmol 1(4):527–533PubMedPubMedCentral

19.

Zhao X, Xia S, Wang E, Chen Y (2017) Comparison of the efficacy and patients' tolerability of Nepafenac and Ketorolac in the treatment of ocular inflammation following cataract surgery: A meta-analysis of randomized controlled trials. PLoS ONE 12(3):e0173254. https://doi.org/10.1371/journal.pone.0173254PubMedPubMedCentralCrossRef

20.

Cagini C, Pellegrino A, Cerquaglia A, Iaccheri B, Lupidi M, Fiore T (2020) Comparison of the effect of diclofenac 0.1% and nepafenac 0.1% on aqueous flare in patients undergoing cataract surgery: a prospective randomized study. Curr Eye Res. https://doi.org/10.1080/02713683.2020.1725061PubMedCrossRef

21.

Duan P, Liu Y, Li J (2017) The comparative efficacy and safety of topical non-steroidal anti-inflammatory drugs for the treatment of anterior chamber inflammation after cataract surgery: a systematic review and network meta-analysis. Graefes Arch Clin Exp Ophthalmol 255(4):639–649. https://doi.org/10.1007/s00417-017-3599-8CrossRef

22.

Kessel L, Tendal B, Jorgensen KJ, Erngaard D, Flesner P, Andresen JL, Hjortdal J (2014) Post-cataract prevention of inflammation and macular edema by steroid and nonsteroidal anti-inflammatory eye drops: a systematic review. Ophthalmology 121(10):1915–1924. https://doi.org/10.1016/j.ophtha.2014.04.035PubMedCrossRef

23.

Ray S, D'Amico DJ (2002) Pseudophakic cystoid macular edema. Semin Ophthalmol 17(3–4):167–180PubMedCrossRef

24.

Dave P, Shah K, Ramchandani B, Jain R (2014) Effect of nepafenac eye drops on intraocular pressure: a randomized prospective study. Am J Ophthalmol 157(3):735–738. https://doi.org/10.1016/j.ajo.2013.12.015PubMedCrossRef

Titel: Comparison of the efficacy of nepafenac 0.1% in quiescent Behçet’s uveitis and non-uveitic healthy patients after phacoemulsification surgery
verfasst von: Mehmed Uğur Işık
Nilüfer F. Yalçındağ
Publikationsdatum: 17.05.2020
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 9/2020
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01419-z

Neu im Fachgebiet Augenheilkunde

08.04.2024 | Therapieverfahren in der Augenheilkunde | CME

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Comparison of the efficacy of nepafenac 0.1% in quiescent Behçet’s uveitis and non-uveitic healthy patients after phacoemulsification surgery

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 9/2020

Inner retinal toxicity due to silicone oil: a case series and review of the literature

Correlation of myopia severity with visual performance

Retinal, choroidal and optic disc analysis in patients with Graves’ disease with or without orbitopathy

Comparison of the diurnal efficacy and safety of cyclocryocoagulation and cyclophotocoagulation in patients with refractory glaucoma

Relationships between the clinical characteristics and copy numbers of DNA of cytomegalovirus determined by real-time PCR

Diurnal fluctuations of macular vessel density in patients with primary open-angle glaucoma and healthy subjects

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde