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23.09.2019 | Original Research Article

Comparison of the uniform-field electroretinogram and the pattern electroretinogram to checkerboard and bar gratings

verfasst von: Alexander J. Lingley, Ange-Lynca Kantungane, Stuart G. Coupland

Erschienen in: Documenta Ophthalmologica

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Abstract

Purpose

To compare the electroretinal response associated with the uniform-field electroretinogram (UF-ERG) to that of the pattern electroretinogram (PERG) to checkerboard and bar-grating stimuli.

Methods

UF-ERG and PERG to bars and checkerboard were recorded for 18 visually normal subjects (36 eyes) of mean age 45 years (range 20–75). UF-ERG was recorded to the increment and decrement of a 200-ms duration luminance modulation. Luminance onset and offset UF-ERG responses were averaged to produce a simulation of the PERG response. The mean amplitude and implicit time for the P50 and N95 potentials of actual and simulated PERG responses were recorded for each eye in the cohort.

Results

The simulated PERG waveform resulting from arithmetic averaging of the UF-ERG to luminance increment and decrement was characterized by prominent positive and negative components resembling those of the P50 and N95 PERG potentials. Implicit timing of the P50 potential was lengthened in the actual PERG to bars and checks relative to that of the simulation (P < 0.05, P < 0.001). Amplitude of the N95 potential was greater in the PERG to bars than in the PERG to checks (P < 0.05) or the simulated PERG (P < 0.001). The amplitude and implicit timing of all waveform components were significantly correlated between the actual and simulated PERG.

Conclusions

The UF-ERG to light onset and offset can be reliably recorded in human subjects. The extent to which the simulated PERG recapitulates the actual PERG response is better with checkerboard rather than bar-grating stimuli.
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Metadaten
Titel
Comparison of the uniform-field electroretinogram and the pattern electroretinogram to checkerboard and bar gratings
verfasst von
Alexander J. Lingley
Ange-Lynca Kantungane
Stuart G. Coupland
Publikationsdatum
23.09.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Documenta Ophthalmologica
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-019-09714-6

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