Comparison of visual results and higher-order aberrations after small incision lenticule extraction (SMILE): high myopia vs. mild to moderate myopia

Small incision lenticule extraction (SMILE) has been reported since 2011, for treatment of myopia and astigmatism [1, 2]. SMILE is a novel and less invasive technique because only a small incision is required and without a flap. Therefore, avoiding the creation of a flap and preserving more corneal nerve fibers, SMILE is expected to remedy the shortcomings of laser-assisted in situ keratomileusis (LASIK) and femtosecond laser-assisted LASIK (FS-LASIK) [3]. Studies have reported that SMILE minimizes dry eye, and maintains higher corneal sensitivity [4]. In addition, the postoperative corneal biomechanical strength is theoretically greater in comparison to LASIK and FS-LASIK [5‐7]. Therefore, SMILE is considered to be a good selection mode for refractive surgery. There have been studies on SMILE techniques, but most reported results on visual acuity and refractive outcomes [8‐10]. It is known that high-order aberrations (HOAs) are always responsible for postoperative symptoms, including halos, glare, monocular diplopia, and decreased contrast sensitivity after successful refractive surgery. Previous study showed that increased HOAs associated with LASIK. Recently, some papers reported that SMILE also induced HOAs [11‐14]. However, there are limited numbers of studied comparing the induced HOAs of SMILE regarding the degree of myopia. The purpose of this study was to evaluate refractive predictability, efficacy, safety and HOAs for mild to moderate myopia and in high myopia.

This is a prospective study, which included 165 eyes from 86 patients. All patients underwent SMILE surgery and completed 3 months follow up postoperatively were included. According to the preoperative spherical equivalent (SE), treated eyes were divided into two groups: the high myopia group (more than -6.0 D,group-H) and the mild to moderate group (less than -6.0 D, group-M). All patients underwent surgery at the Department of Ophthalmology, Second Affiliated Hospital, College of Medicine, Zhejiang University, from July to October, 2016. This research followed the tenets of the Declaration of Helsinki, and informed consent was obtained from the subjects after explanation of the nature and possible consequences of the study. Institutional review board approval was obtained for this study (No: 2016-025). The inclusion criteria included a minimum age of 18 years, no ocular or systemic diseases, stable refraction for at least one year, minimum corneal thickness of 480 μm, and minimum calculated residual stromal bed after a treatment of 280 μm. Patients who wore soft contact lenses were instructed to stop wearing them for at least one week. The two groups were compared with respect to the safety, efficacy, predictability, and HOAs of the SMILE treatment. The safety index (defined as postoperative CDVA/preoperative CDVA) and the efficacy index (defined as the postoperative UDVA/preoperative CDVA) were estimated [9].

In recent years, there has been a growing interest in SMILE as a new alternative refractive surgical option. Publications suggest that SMILE has excellent predictability, safety, and efficacy in correcting myopia and astigmatism [9‐11, 15‐18]. Here, we compare the three month SMILE outcomes between high myopia patients and mild to moderate myopia patients. It is a particularly accurate comparison because all of the SMILE surgery was performed by the same experienced surgeon. Moreover, we controlled surgical factors (e.g., laser energy setting) to precisely evaluate the efficacy, safety, predictability, and stability of SMILE. Also, we observed the HOAs changes after the SMILE surgery.

Regarding efficacy, UDVA improved gradually overtime after surgery in our study. Postoperatively, 77% of eyes in group-H and 98% in group-M had an UDVA of 20/20 or better at three months, respectively. The results were in accordance with results of other studies. Kim et al [16]. reported that 77% and 93% of eyes had 20/20 or better UDVA at 12 months in high and low to moderate myopia patients, respectively. Additionally, 80% to 96% of eyes were reported to have 20/20 or better UDVA at six months in low to high myopia patients in previous studies [15, 19, 20]. The higher success rate was seen in the mild to moderate group in our study.

For predictability and stability, the SE in group-H showed undercorrected. However, the SE in group-M was closer to the target refraction. At three months, 87% and 95% were within ± 0.5 D and ± 1.0 D of the intended correction in group-H, and 98% and 100% in group-M, respectively. There was no obvious regression in the three month follow-up time. In accordance with our results, Kim et al. [16] reported that 88% and 98% were within ± 0.5 D and ± 1.0 D in the high myopia patients and 88% and 97% in the low to moderate myopia patients at 12 months, respectively. Kim et al. suggested that SMILE surgery has a similar predictability, independent of the amount of myopic correction [16]. However, we suppose that the intended corrected myopia amount in high myopia patients should be revised in our future work, which will avoid the undercorrection in high myopia patient.

Regarding safety, two eyes lost one line of CDVA, 98% and 99% had a CDVA of 20/20 in group-H and group-M, respectively. However, different results were reported in other studies. Kim et al. [15] previously reported that 49% of eyes had an unchanged CDVA, 41% gained one line, 7% acquired two lines, 3% lost one line, and 0.3% lost two lines at six months. In another report of a one year follow-up by Kim et al. [16], 3% and 3% of eyes lost one line of CDVA, 37% and 43% were the same, 53% and 47% gained one line, and 7% and 6% of eyes gained two lines in mild to moderate myopia patients and in high myopia patients, respectively. In the report by Shah et al. [1], 4% of eyes lost one line, and 96% were unchanged or improved at six months. In the study by Sekundo et al. [20], 11% of eyes lost one line, and 89% were unchanged or improved at 12 months. This discrepancy may have resulted because our results were taken three months after surgery, which was a shorter follow-up time than in the other studies.

Some paper described the most frequent complication of the surgery, such as corneal haze, suction loss, small tear at the incision edge, cap perforation, difficult lenticule extraction [21], and residue of part of the intrastromal lenticule [22]. The incidence of suction loss in SMILE surgery was 4.4% in Wong et al. [23] and 2.1% in Osman et al [24]. In this study, suction loss occurred in three eyes of two patients (1.8%) during the small incision side cut procedure of the cap. After appropriate management, good visual outcomes were achieved. Other complications, such as epithelial ingrowths and haze, were not observed in this study.

HOAs contributed to the influence of visual quality after refractive surgery. Previous studies have shown that HOAs commonly increased after LASIK procedures. Recently, there have been some published studies on the induction of HOAs after SMILE [1, 12‐14, 20, 25‐27]. Shah et al. [1] found a significant increase in the RMS, higher-order coma aberrations, spherical aberrations, and 4^th-order astigmatism, but there was no significant change in trefoil six months after SMILE. Sekundo et al. [20] observed that RMS, spherical aberration, and coma increased one year after SMILE surgery. Agca et al. [25] found that RMS, spherical aberration, coma, and trefoil increased after femtosecond lenticule extraction (FLEx) and SMILE surgery. Chen et al. [12] reported that a higher vertical coma was found in SMILE, and this was correlated to preoperative SE. Accurate centration during the SMILE procedure and controlling wound healing might be critical to minimize the induced coma. Yu et al [13] observed that the decentration displacement in SMILE was less than SBK surgery; however, vertical decentration would induce spherical aberration in SMILE surgery. Li et al. [27] demonstrated that the horizontal decentration induced horizontal coma, but the association between the magnitude of vertical decentration and the induced vertical coma tended to be nonexistent. In our study, the RMS and 3^rd-order horizontal coma, 4^th-order spherical aberration, 4^th-order oblique quadrfoil, and 4^th-order vertical secondary astigmatism increased significantly in both groups after surgery (p < 0.05). The magnitude of horizontal coma and spherical aberration are obvious (Fig. 7). The increase of spherical aberration was higher in group-H than in group-M. Han et al. [26] observed a significant increase of spherical aberration and coma after SMILE surgery, which did not decrease over the four years of follow-up. Among high order aberrations, postoperative coma was most affected and remained stable at all follow-up time points. In conclusion, the induction of spherical aberration is associated directly with the magnitude of the attempted diopters and ocular coma is associated with the magnitude of decentration. There exists varying conclusions may be due to the complicated influence factors, such as gravity, corneal irregularity, corneal haze, wound healing, amount of time following surgery, and intraocular pressure [27]. There maybe some relations with the corrected diopter, the position of cap rim cut, and the decentration ablation. However, the sample size of Group-H in the manuscript may not have sufficient statistical power (n=62) to detect differences. We used G-Power software (https://​www.​gpower.​hhu.​de/​) to estimate the sample size. The statistical method is independent-samples T test. The α(the Type I error probability for a two sided test)was set to be 0.05, the power ( the probability of correctly rejecting the null hypothesis) was set to be 0.8, the effect size was set to be 0.5, and the allocation ratio (the ratio of control to experimental subjects) was set to be 1. And the results indicated that a total of 64 Group-H subjects and 64 Group-M subjects should be involved in our study. In our future work, the long-term changes of aberrations and a large sample size on SMILE still need further observation and discussion.

There were some limitations in this study. Firstly, this study included 165 eyes, and the available data covered only three months. A larger sample size and longer observation term were needed. Secondly, for bilaterally treated patients, both eyes were included, even though the two eyes of one patient are potentially correlated. This is a common mistake in ophthalmology research since the variance between eyes is usually less than that between subjects; the overall variance of a sample of measurements combined from both eyes is likely to be an underestimate of the true variance resulting in an increased risk of a Type 1 error [28]. Future research on the associations among visual quality, HOAs, and corneal biomechanics should be performed.

In conclusion, our data indicates that SMILE is an effective and safe refractive surgical option. SMILE provides a predictable and stable correction of mild to moderate myopia. In high myopia patients, the intended correction should be modified, especially considering the age, occupation and dominate eye of patients. SMILE induced increases of HOAs. Further and larger studies on longer-term results are needed.