The online version of this article (doi:10.1186/1471-230X-14-162) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
JW acquired the data, performed statistical analysis and wrote the manuscript; RAH acquired the data and performed statistical analysis. RKW and JJK were responsible for the study concept and design, and were involved in editing the manuscript. All authors read and approved the final manuscript.
In up to 30 percent of small bowel capsule endoscopy procedures, the capsule does not reach the cecum within recording time. A prolonged gastric transit time has been recognized as a risk factor for incomplete capsule endoscopy. The aim of this study was to analyze if a single dose of orally administered erythromycin prior to capsule endoscopy results in a higher completion rate compared to orally administered domperidone.
Single centre, non-concurrent prospective cohort study, 649 capsule endoscopy procedures were included. Cecal completion rates, gastric and small bowel transit times and diagnostic yield were analyzed.
239 patients received erythromycin, 410 patients received domperidone. The cecal completion rate was 86% after erythromycin versus 80% after domperidone (p = 0.03). After excluding known risk factors for incomplete capsule endoscopy such as hospitalization and previous abdominal surgery, erythromycin still resulted in an increased completion rate (p = 0.04). Median gastric transit time was lower after erythromycin compared to domperidone (13 min versus 22 min, p < 0.001). Median small bowel transit times were similar in both groups (236 min versus 248 min, p = 0.21).
In this study, the largest to date on this subject, the cecal completion rate was higher with erythromycin than with domperidone, but there was no difference in the diagnostic yield.
Lee H, Condon D, Mineyama Y, Wallace D: Effect of Erythromycin on transit time in video capsule endoscopy: a randomized prospective placebo controlled trial. Gastrointest Endosc. 2006, 63: AB 159-
Prather CM, Camilleri M, Thomforde GM, Zinsmeister AR: Gastric axial forces in experimentally delayed and accelerated gastric emptying. Am J Physiol. 1993, 264: G928-G934. PubMed
Keshavarzian A, Isaac RM: Erythromycin accelerates gastric emptying of indigestible solids and transpyloric migration of the tip of an enteral feeding tube in fasting and fed states. Am J Gastroenterol. 1993, 88: 193-197. PubMed
BruleydesVarannes S, Parys V, Ropert A, Chayvialle JA, Rozé C, Galmiche JP: Erythromycin enhances fasting and postprandial proximal gastric tone in humans. Gastroenterology. 1995, 109: 32-39. 10.1016/0016-5085(95)90266-X. CrossRef
Maganti K, Onyemere K, Jones MP: Oral erythromycin and symptomatic relieve of gastroparesis; a systematic review. Am J Gastroenterol. 2003, 98: 259-263. PubMed
Korman LY, Delvaux M, Gay G, Hagenmuller F, Keuchel M, Friedman S, Weinstein M, Shetzline M, Cave D, de Franchis R: Capsule endoscopy structured terminology (CEST): proposal of a standardized and structured terminology for reporting capsule endoscopy procedures. Endoscopy. 2005, 37: 951-959. 10.1055/s-2005-870329. CrossRefPubMed
Lai LH, Wong GLH, Lau JJY: Initial experience of real-time capsule endoscopy in monitoring progress of the video capsule trough the upper GI tract. Gastointest Endosc. 2007, 66: 1211-1214. 10.1016/j.gie.2007.04.011. CrossRef
Koulaouzidis A, Dimitriadis S, Douglas S, Plevris JN: The use of domperidone increases the completion rate of small bowel capsule endoscopy: does this come at the expense of diagnostic yield?. J Clin Gastroentero. 2014, [Epub ahead of print]
- Completion rate of small bowel capsule endoscopy is higher after erythromycin compared to domperidone
Rinse K Weersma
Reinier A Hoedemaker
Jan J Koornstra
- BioMed Central
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II