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Erschienen in: Langenbeck's Archives of Surgery 1/2019

14.12.2018 | ORIGINAL ARTICLE

Complex gastric surgery in Germany—is centralization beneficial? Observational study using national hospital discharge data

verfasst von: Ulrike Nimptsch, Thomas Haist, Ines Gockel, Thomas Mansky, Dietmar Lorenz

Erschienen in: Langenbeck's Archives of Surgery | Ausgabe 1/2019

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Abstract

Purpose

This observational study explored the association between hospital volume and short-term outcome following gastric resections for non-bariatric indication, aiming to contribute to the discussion on centralization of complex visceral surgery in Germany.

Methods

Based on complete national hospital discharge data from 2010 to 2015, the association between hospital volume and in-hospital mortality was evaluated according to volume quintiles and volume deciles. Case-mix differences regarding surgical indication, age, sex, and comorbidities were considered for risk adjustment. In addition, rates of major complications and failure to rescue were analyzed across hospital volume categories.

Results

Inpatient episodes (72,528) with gastric resection were analyzed. Risk-adjusted mortality in patients treated in very low volume hospitals (median volume of 5 surgeries per year) was higher (12.0% [95% CI 11.4 to 12.5]) compared to those treated in very high volume hospitals (50 surgeries per year; 10.6% [10.0 to 11.1]). Failure to rescue patients with complications was 28.1% [27.0 to 29.3] in very low volume hospitals and 22.7% [21.6 to 23.8] in very high volume hospitals. Differences were similar within the subgroup of patients operated for gastric cancer.

Conclusions

Treatment in very high volume hospitals is associated with a lower in-hospital mortality compared to treatment in very low volume hospitals. This effect seems to be determined by the ability to rescue patients who experience complications. As the observed benefit is only related to very high volumes, the results do not clearly indicate that centralization may improve short-term results substantially, unless a very high degree of centralization would be achieved. Possibly, further research focusing on other outcome measures, such as clinical processes or long-term results, might lead to divergent conclusions.
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Literatur
1.
Zurück zum Zitat Hahn KY, Park CH, Lee YK, Chung H, Park JC, Shin SK, Lee YC, Kim HI, Cheong JH, Hyung WJ, Noh SH, Lee SK (2018) Comparative study between endoscopic submucosal dissection and surgery in patients with early gastric cancer. Surg Endosc 32:73–86CrossRefPubMed Hahn KY, Park CH, Lee YK, Chung H, Park JC, Shin SK, Lee YC, Kim HI, Cheong JH, Hyung WJ, Noh SH, Lee SK (2018) Comparative study between endoscopic submucosal dissection and surgery in patients with early gastric cancer. Surg Endosc 32:73–86CrossRefPubMed
2.
Zurück zum Zitat Busweiler LA, Wijnhoven BP, van Berge Henegouwen MI, Henneman D, van Grieken NC, Wouters MW, Dutch Upper Gastrointestinal Cancer Audit (DUCA) Group et al (2016) Early outcomes from the Dutch Upper Gastrointestinal Cancer Audit. Br J Surg 103:1855–1863CrossRefPubMed Busweiler LA, Wijnhoven BP, van Berge Henegouwen MI, Henneman D, van Grieken NC, Wouters MW, Dutch Upper Gastrointestinal Cancer Audit (DUCA) Group et al (2016) Early outcomes from the Dutch Upper Gastrointestinal Cancer Audit. Br J Surg 103:1855–1863CrossRefPubMed
3.
Zurück zum Zitat Søreide K, Thorsen K, Søreide JA (2014) Strategies to improve the outcome of emergency surgery for perforated peptic ulcer. Br J Surg 101:e51–e64CrossRefPubMed Søreide K, Thorsen K, Søreide JA (2014) Strategies to improve the outcome of emergency surgery for perforated peptic ulcer. Br J Surg 101:e51–e64CrossRefPubMed
4.
Zurück zum Zitat Gruen RL, Pitt V, Green S, Parkhill A, Campbell D, Jolley D (2009) The effect of provider case volume on cancer mortality: systematic review and meta-analysis. CA Cancer J Clin 59:192–211CrossRefPubMed Gruen RL, Pitt V, Green S, Parkhill A, Campbell D, Jolley D (2009) The effect of provider case volume on cancer mortality: systematic review and meta-analysis. CA Cancer J Clin 59:192–211CrossRefPubMed
5.
Zurück zum Zitat Tol JA, van Gulik TM, Busch OR, Gouma DJ (2012) Centralization of highly complex low-volume procedures in upper gastrointestinal surgery. A summary of systematic reviews and meta-analyses. Dig Surg 29:374–383CrossRefPubMed Tol JA, van Gulik TM, Busch OR, Gouma DJ (2012) Centralization of highly complex low-volume procedures in upper gastrointestinal surgery. A summary of systematic reviews and meta-analyses. Dig Surg 29:374–383CrossRefPubMed
6.
Zurück zum Zitat Ghaferi AA, Birkmeyer JD, Dimick JB (2011) Hospital volume and failure to rescue with high-risk surgery. Med Care 49:1076–1081CrossRefPubMed Ghaferi AA, Birkmeyer JD, Dimick JB (2011) Hospital volume and failure to rescue with high-risk surgery. Med Care 49:1076–1081CrossRefPubMed
8.
Zurück zum Zitat Stroh C, Birk D, Flade-Kuthe R, Frenken M, Herbig B, Hohne S et al (2009) Working Group Bariatric Surgery. Status of bariatric surgery in Germany—results of the nationwide survey on bariatric surgery 2005-2007. Obes Facts 2(Suppl 1):2–7CrossRefPubMedPubMedCentral Stroh C, Birk D, Flade-Kuthe R, Frenken M, Herbig B, Hohne S et al (2009) Working Group Bariatric Surgery. Status of bariatric surgery in Germany—results of the nationwide survey on bariatric surgery 2005-2007. Obes Facts 2(Suppl 1):2–7CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Weledji EP, Verla V (2016) Failure to rescue patients from early critical complications of oesophagogastric cancer surgery. Ann Med Surg (Lond) 7:34–41CrossRef Weledji EP, Verla V (2016) Failure to rescue patients from early critical complications of oesophagogastric cancer surgery. Ann Med Surg (Lond) 7:34–41CrossRef
10.
Zurück zum Zitat Busweiler LA, Henneman D, Dikken JL, Fiocco M, van Berge Henegouwen MI, Wijnhoven BP, Dutch Upper GI Cancer Audit group et al (2017) Failure-to-rescue in patients undergoing surgery for esophageal or gastric cancer. Eur J Surg Oncol 43:1962–1969CrossRefPubMed Busweiler LA, Henneman D, Dikken JL, Fiocco M, van Berge Henegouwen MI, Wijnhoven BP, Dutch Upper GI Cancer Audit group et al (2017) Failure-to-rescue in patients undergoing surgery for esophageal or gastric cancer. Eur J Surg Oncol 43:1962–1969CrossRefPubMed
11.
Zurück zum Zitat Markar SR, Karthikesalingam A, Thrumurthy S, Low DE (2012) Volume-outcome relationship in surgery for esophageal malignancy: systematic review and meta-analysis 2000-2011. J Gastrointest Surg 16:1055–1063CrossRefPubMed Markar SR, Karthikesalingam A, Thrumurthy S, Low DE (2012) Volume-outcome relationship in surgery for esophageal malignancy: systematic review and meta-analysis 2000-2011. J Gastrointest Surg 16:1055–1063CrossRefPubMed
12.
Zurück zum Zitat Wouters MW, Gooiker GA, van Sandick JW, Tollenaar RA (2012) The volume-outcome relation in the surgical treatment of esophageal cancer: a systematic review and meta-analysis. Cancer 118:1754–1763CrossRefPubMed Wouters MW, Gooiker GA, van Sandick JW, Tollenaar RA (2012) The volume-outcome relation in the surgical treatment of esophageal cancer: a systematic review and meta-analysis. Cancer 118:1754–1763CrossRefPubMed
13.
Zurück zum Zitat Baré M, Cabrol J, Real J, Navarro G, Campo R, Pericay C, Sarría A (2009) In-hospital mortality after stomach cancer surgery in Spain and relationship with hospital volume of interventions. BMC Public Health 9:312CrossRefPubMedPubMedCentral Baré M, Cabrol J, Real J, Navarro G, Campo R, Pericay C, Sarría A (2009) In-hospital mortality after stomach cancer surgery in Spain and relationship with hospital volume of interventions. BMC Public Health 9:312CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Reavis KM, Hinojosa MW, Smith BR, Wooldridge JB, Krishnan S, Nguyen NT (2009) Hospital volume is not a predictor of outcomes after gastrectomy for neoplasm. Am Surg 75:932–936PubMed Reavis KM, Hinojosa MW, Smith BR, Wooldridge JB, Krishnan S, Nguyen NT (2009) Hospital volume is not a predictor of outcomes after gastrectomy for neoplasm. Am Surg 75:932–936PubMed
15.
Zurück zum Zitat Smith RC, Creighton N, Lord RV, Merrett ND, Keogh GW, Liauw WS, Currow DC (2014) Survival, mortality and morbidity outcomes after oesophagogastric cancer surgery in New South Wales, 2001-2008. Med J Aust 200:408–413CrossRefPubMed Smith RC, Creighton N, Lord RV, Merrett ND, Keogh GW, Liauw WS, Currow DC (2014) Survival, mortality and morbidity outcomes after oesophagogastric cancer surgery in New South Wales, 2001-2008. Med J Aust 200:408–413CrossRefPubMed
16.
Zurück zum Zitat Birkmeyer JD, Siewers AE, Finlayson EV, Stukel TA, Lucas FL, Batista I et al (2002) Hospital volume and surgical mortality in the United States. N Engl J Med 346:1128–1137CrossRefPubMed Birkmeyer JD, Siewers AE, Finlayson EV, Stukel TA, Lucas FL, Batista I et al (2002) Hospital volume and surgical mortality in the United States. N Engl J Med 346:1128–1137CrossRefPubMed
17.
Zurück zum Zitat Learn PA, Bach PB (2010) A decade of mortality reductions in major oncologic surgery: the impact of centralization and quality improvement. Med Care 48:1041–1049CrossRefPubMed Learn PA, Bach PB (2010) A decade of mortality reductions in major oncologic surgery: the impact of centralization and quality improvement. Med Care 48:1041–1049CrossRefPubMed
18.
Zurück zum Zitat Pasquer A, Renaud F, Hec F, Gandon A, Vanderbeken M, Drubay V, FREGAT Working GroupFRENCH et al (2016) Is centralization needed for esophageal and gastric cancer patients with low operative risk?: a nationwide study. Ann Surg 264:823–830CrossRefPubMed Pasquer A, Renaud F, Hec F, Gandon A, Vanderbeken M, Drubay V, FREGAT Working GroupFRENCH et al (2016) Is centralization needed for esophageal and gastric cancer patients with low operative risk?: a nationwide study. Ann Surg 264:823–830CrossRefPubMed
19.
Zurück zum Zitat Krautz C, Nimptsch U, Weber GF, Mansky T, Grützmann R (2018) Effect of hospital volume on in-hospital morbidity and mortality following pancreatic surgery in Germany. Ann Surg 267:411–417CrossRefPubMed Krautz C, Nimptsch U, Weber GF, Mansky T, Grützmann R (2018) Effect of hospital volume on in-hospital morbidity and mortality following pancreatic surgery in Germany. Ann Surg 267:411–417CrossRefPubMed
20.
Zurück zum Zitat Nimptsch U, Haist T, Krautz C, Grützmann R, Mansky T, Lorenz D (2018) Hospital volume, in-hospital mortality and failure to rescue in esophageal surgery—analysis of German national hospital discharge data from 2010 to 2015. Dtsch Arztebl Int 115:793–800 Nimptsch U, Haist T, Krautz C, Grützmann R, Mansky T, Lorenz D (2018) Hospital volume, in-hospital mortality and failure to rescue in esophageal surgery—analysis of German national hospital discharge data from 2010 to 2015. Dtsch Arztebl Int 115:793–800
21.
Zurück zum Zitat Markar SR, Mackenzie H, Wiggins T, Askari A, Karthikesalingam A, Faiz O, Griffin SM, Birkmeyer JD, Hanna GB (2018) Influence of national centralization of oesophagogastric cancer on management and clinical outcome from emergency upper gastrointestinal conditions. Br J Surg 105:113–120CrossRefPubMed Markar SR, Mackenzie H, Wiggins T, Askari A, Karthikesalingam A, Faiz O, Griffin SM, Birkmeyer JD, Hanna GB (2018) Influence of national centralization of oesophagogastric cancer on management and clinical outcome from emergency upper gastrointestinal conditions. Br J Surg 105:113–120CrossRefPubMed
22.
Zurück zum Zitat Jensen LS, Nielsen H, Mortensen PB, Pilegaard HK, Johnsen SP (2010) Enforcing centralization for gastric cancer in Denmark. Eur J Surg Oncol 36:S50–S54CrossRefPubMed Jensen LS, Nielsen H, Mortensen PB, Pilegaard HK, Johnsen SP (2010) Enforcing centralization for gastric cancer in Denmark. Eur J Surg Oncol 36:S50–S54CrossRefPubMed
23.
Zurück zum Zitat Nimptsch U, Krautz C, Weber GF, Mansky T, Grützmann R (2016) Nationwide in-hospital mortality following pancreatic surgery in Germany is higher than anticipated. Ann Surg 264:1082–1090CrossRefPubMed Nimptsch U, Krautz C, Weber GF, Mansky T, Grützmann R (2016) Nationwide in-hospital mortality following pancreatic surgery in Germany is higher than anticipated. Ann Surg 264:1082–1090CrossRefPubMed
24.
Zurück zum Zitat Ptok H, Gastinger I, Meyer F, Ilsemann A, Lippert H, Bruns C (2017) Hospital volume effects in surgical treatment of gastric cancer: results of a prospective multicenter observational study. Chirurg 88:328–338CrossRefPubMed Ptok H, Gastinger I, Meyer F, Ilsemann A, Lippert H, Bruns C (2017) Hospital volume effects in surgical treatment of gastric cancer: results of a prospective multicenter observational study. Chirurg 88:328–338CrossRefPubMed
27.
Zurück zum Zitat Nimptsch U, Wengler A, Mansky T (2016) Continuity of hospital identifiers in hospital discharge data - analysis of the nationwide German DRG statistics from 2005 to 2013. Z Evid Fortbild Qual Gesundhwes 117:38–44CrossRefPubMed Nimptsch U, Wengler A, Mansky T (2016) Continuity of hospital identifiers in hospital discharge data - analysis of the nationwide German DRG statistics from 2005 to 2013. Z Evid Fortbild Qual Gesundhwes 117:38–44CrossRefPubMed
28.
Zurück zum Zitat Enzinger PC, Benedetti JK, Meyerhardt JA, McCoy S, Hundahl SA, Macdonald JS, Fuchs CS (2007) Impact of hospital volume on recurrence and survival after surgery for gastric cancer. Ann Surg 245:426–434CrossRefPubMedPubMedCentral Enzinger PC, Benedetti JK, Meyerhardt JA, McCoy S, Hundahl SA, Macdonald JS, Fuchs CS (2007) Impact of hospital volume on recurrence and survival after surgery for gastric cancer. Ann Surg 245:426–434CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Xirasagar S, Lien YC, Lin HC, Lee HC, Liu TC, Tsai J (2008) Procedure volume of gastric cancer resections versus 5-year survival. Eur J Surg Oncol 34:23–29CrossRefPubMed Xirasagar S, Lien YC, Lin HC, Lee HC, Liu TC, Tsai J (2008) Procedure volume of gastric cancer resections versus 5-year survival. Eur J Surg Oncol 34:23–29CrossRefPubMed
30.
Zurück zum Zitat Thompson AM, Rapson T, Gilbert FJ, Park KG, Scottish Audit of Gastric and Oesophageal Cancer (2007) Hospital volume does not influence long-term survival of patients undergoing surgery for oesophageal or gastric cancer. Br J Surg 94:578–584CrossRefPubMed Thompson AM, Rapson T, Gilbert FJ, Park KG, Scottish Audit of Gastric and Oesophageal Cancer (2007) Hospital volume does not influence long-term survival of patients undergoing surgery for oesophageal or gastric cancer. Br J Surg 94:578–584CrossRefPubMed
Metadaten
Titel
Complex gastric surgery in Germany—is centralization beneficial? Observational study using national hospital discharge data
verfasst von
Ulrike Nimptsch
Thomas Haist
Ines Gockel
Thomas Mansky
Dietmar Lorenz
Publikationsdatum
14.12.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Langenbeck's Archives of Surgery / Ausgabe 1/2019
Print ISSN: 1435-2443
Elektronische ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-018-1742-6

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